{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:04:15Z","timestamp":1790723055049,"version":"4.1.0"},"reference-count":69,"publisher":"The Company of Biologists","issue":"14","license":[{"start":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["1R56DK123610-01"],"award-info":[{"award-number":["1R56DK123610-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Noncanonical Wnt\/planar cell polarity (Wnt\/PCP) signaling has been implicated in endoderm morphogenesis. However, the underlying cellular and molecular mechanisms of this process are unclear. We found that, during convergence and extension (C&amp;E) in zebrafish, gut endodermal cells are polarized mediolaterally, with GFP-Vangl2 enriched at the anterior edges. Endoderm cell polarity is lost and intercalation is impaired in the absence of glypican 4 (gpc4), a heparan-sulfate proteoglycan that promotes Wnt\/PCP signaling, suggesting that this signaling is required for endodermal cell polarity. Live imaging revealed that endoderm C&amp;E is accomplished by polarized cell protrusions and junction remodeling, which are impaired in gpc4-deficient endodermal cells. Furthermore, in the absence of gpc4, Cadherin 2 expression on the endodermal cell surface is increased as a result of impaired Rab5c-mediated endocytosis, which partially accounts for the endodermal defects in these mutants. These findings indicate that Gpc4 regulates endodermal planar cell polarity during endoderm C&amp;E by influencing the localization of Cadherin 2. Thus, our study uncovers a new mechanism by which Gpc4 regulates planar cell polarity and reveals the role of Wnt\/PCP signaling in endoderm morphogenesis.<\/jats:p>","DOI":"10.1242\/dev.199421","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T08:12:56Z","timestamp":1623831176000},"source":"Crossref","is-referenced-by-count":18,"title":["Glypican 4 regulates planar cell polarity of endoderm cells by controlling the localization of Cadherin 2"],"prefix":"10.1242","volume":"148","author":[{"given":"Anurag Kakkerla","family":"Balaraju","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Murry","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2179-7031","authenticated-orcid":false,"given":"Fang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2021,7,12]]},"reference":[{"key":"2021073011192645800_DEV199421C1","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/nature02590","article-title":"Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation","volume":"429","author":"Bertet","year":"2004","journal-title":"Nature"},{"key":"2021073011192645800_DEV199421C2","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.devcel.2006.09.007","article-title":"Multicellular rosette formation links planar cell polarity to tissue morphogenesis","volume":"11","author":"Blankenship","year":"2006","journal-title":"Dev. 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