{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:45:45Z","timestamp":1792251945102,"version":"4.4.0"},"reference-count":30,"publisher":"The Company of Biologists","issue":"19","license":[{"start":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T00:00:00Z","timestamp":1632441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["16H02478"],"award-info":[{"award-number":["16H02478"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["19H00978"],"award-info":[{"award-number":["19H00978"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["26430183"],"award-info":[{"award-number":["26430183"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007951","name":"Tokyo Medical and Dental University","doi-asserted-by":"crossref","award":["2020-40"],"award-info":[{"award-number":["2020-40"]}],"id":[{"id":"10.13039\/501100007951","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005865","name":"Mochida Memorial Foundation for Medical and Pharmaceutical Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005865","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The therian-specific gene paternally expressed 10 (Peg10) plays an essential role in placenta formation: Peg10 knockout mice exhibit early embryonic lethality as a result of severe placental defects. The PEG10 protein exhibits homology with long terminal repeat (LTR) retrotransposon GAG and POL proteins; therefore, we generated mice harboring a mutation in the highly conserved viral aspartic protease motif in the POL-like region of PEG10 because this motif is essential for the life cycle of LTR retrotransposons\/retroviruses. Intriguingly, frequent perinatal lethality, not early embryonic lethality, was observed with fetal and placental growth retardation starting mid-gestation. In the mutant placentas, severe defects were observed in the fetal vasculature, where PEG10 is expressed in the three trophoblast cell layers that surround fetal capillary endothelial cells. Thus, Peg10 has essential roles, not only in early placenta formation, but also in placental vasculature maintenance from mid- to late-gestation. This implies that along the feto-maternal placenta interface an interaction occurs between two retrovirus-derived genes, Peg10 and retrotransposon Gag like 1 (Rtl1, also called Peg11), that is essential for the maintenance of fetal capillary endothelial cells.<\/jats:p>","DOI":"10.1242\/dev.199564","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T07:16:02Z","timestamp":1685430962000},"source":"Crossref","is-referenced-by-count":45,"title":["PEG10 viral aspartic protease domain is essential for the maintenance of fetal capillary structure in the mouse placenta"],"prefix":"10.1242","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2553-6971","authenticated-orcid":false,"given":"Hirosuke","family":"Shiura","sequence":"first","affiliation":[{"name":"University of Yamanashi 1 Faculty of Life and Environmental Sciences , , Yamanashi 400-8510 , Japan"},{"name":"Medical Research Institute (MRI), Tokyo Medical and Dental University (TMDU) 2 Department of Epigenetics , , Tokyo 113-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1081-0395","authenticated-orcid":false,"given":"Ryuichi","family":"Ono","sequence":"additional","affiliation":[{"name":"Center for Biological Safety and Research, National Institute of Health Sciences (NIHS) 3 Division of Cellular and Molecular Toxicology , , Kanagawa 210-9501 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saori","family":"Tachibana","sequence":"additional","affiliation":[{"name":"Medical Research Institute (MRI), Tokyo Medical and Dental University (TMDU) 2 Department of Epigenetics , , Tokyo 113-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6856-5601","authenticated-orcid":false,"given":"Takashi","family":"Kohda","sequence":"additional","affiliation":[{"name":"University of Yamanashi 1 Faculty of Life and Environmental Sciences , , Yamanashi 400-8510 , Japan"},{"name":"Medical Research Institute (MRI), Tokyo Medical and Dental University (TMDU) 2 Department of Epigenetics , , Tokyo 113-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2566-9961","authenticated-orcid":false,"given":"Tomoko","family":"Kaneko-Ishino","sequence":"additional","affiliation":[{"name":"School of Medicine, Tokai University 4 Faculty of Nursing , , Kanagawa 259-1193 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8458-6069","authenticated-orcid":false,"given":"Fumitoshi","family":"Ishino","sequence":"additional","affiliation":[{"name":"Medical Research Institute (MRI), Tokyo Medical and Dental University (TMDU) 2 Department of Epigenetics , , Tokyo 113-8510 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2021,9,24]]},"reference":[{"key":"2023053007150953700_DEV199564C1","doi-asserted-by":"publisher","first-page":"e0214110","DOI":"10.1371\/journal.pone.0214110","article-title":"The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification","volume":"14","author":"Abed","year":"2019","journal-title":"PLoS ONE"},{"key":"2023053007150953700_DEV199564C2","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1006\/dbio.2002.0773","article-title":"Interactions between trophoblast cells and the maternal and fetal circulation in the mouse placenta","volume":"250","author":"Adamson","year":"2002","journal-title":"Dev. 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