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Although morphological changes during acrosome biogenesis in spermatogenesis have been well described, the molecular mechanism underlying this process is still largely unknown. Family with sequence similarity 71, member F1 and F2 (FAM71F1 and FAM71F2) are testis-enriched proteins that contain a RAB2B-binding domain, a small GTPase involved in vesicle transport and membrane trafficking. Here, by generating mutant mice for each gene, we found that Fam71f1 is essential for male fertility. In Fam71f1-mutant mice, the acrosome was abnormally expanded at the round spermatid stage, likely because of enhanced vesicle trafficking. Mass spectrometry analysis after immunoprecipitation indicated that, in testes, FAM71F1 binds not only RAB2B, but also RAB2A. Further study suggested that FAM71F1 binds to the GTP-bound active form of RAB2A\/B, but not the inactive form. These results indicate that a complex of FAM71F1 and active RAB2A\/B suppresses excessive vesicle trafficking during acrosome formation.<\/jats:p>","DOI":"10.1242\/dev.199644","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T15:00:24Z","timestamp":1635519624000},"source":"Crossref","is-referenced-by-count":38,"title":["FAM71F1 binds to RAB2A and RAB2B and is essential for acrosome formation and male fertility in mice"],"prefix":"10.1242","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5572-8734","authenticated-orcid":false,"given":"Akane","family":"Morohoshi","sequence":"first","affiliation":[{"name":"Department of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan"},{"name":"Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4758-5803","authenticated-orcid":false,"given":"Haruhiko","family":"Miyata","sequence":"additional","affiliation":[{"name":"Department of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4579-5487","authenticated-orcid":false,"given":"Yuki","family":"Oyama","sequence":"additional","affiliation":[{"name":"Department of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan"},{"name":"Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7606-732X","authenticated-orcid":false,"given":"Seiya","family":"Oura","sequence":"additional","affiliation":[{"name":"Department of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan"},{"name":"Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0260-7861","authenticated-orcid":false,"given":"Taichi","family":"Noda","sequence":"additional","affiliation":[{"name":"Department of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan"},{"name":"Division of Reproductive Biology, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto 860-0811, Japan"},{"name":"Priority Organization for Innovation and Excellence, Kumamoto University, Kumamoto 860-8555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9859-6217","authenticated-orcid":false,"given":"Masahito","family":"Ikawa","sequence":"additional","affiliation":[{"name":"Department of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan"},{"name":"Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan"},{"name":"Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan"},{"name":"Laboratory of Reproductive Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan"},{"name":"Center for Infectious Disease Education and Research (CiDER), Osaka University, Osaka 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2021,10,29]]},"reference":[{"key":"2021102915000489500_DEV199644C1","doi-asserted-by":"publisher","first-page":"22250","DOI":"10.1074\/jbc.M115.669242","article-title":"Small GTPase Rab2B and Its specific binding protein Golgi-associated rab2b interactor-like 4 (GARI-l4) regulate Golgi morphology","volume":"290","author":"Aizawa","year":"2015","journal-title":"J. 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