{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:08:05Z","timestamp":1788318485340,"version":"build-2803163510"},"reference-count":82,"publisher":"The Company of Biologists","issue":"17","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["1RF1 AG053391-01"],"award-info":[{"award-number":["1RF1 AG053391-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"crossref","award":["A20135245"],"award-info":[{"award-number":["A20135245"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100018576","name":"Harrington Discovery Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100018576","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Circle of Friends Pilot Synergy"},{"name":"Bluefield Project to Cure FTD"},{"name":"FoRUM of the Ruhr-Universit\u00e4t Bochum"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Reelin is a large secreted glycoprotein that regulates neuronal migration, lamination and establishment of dendritic architecture in the embryonic brain. Reelin expression switches postnatally from Cajal-Retzius cells to interneurons. However, reelin function in interneuron development is still poorly understood. Here, we have investigated the role of reelin in interneuron development in the postnatal neocortex. To preclude early cortical migration defects caused by reelin deficiency, we employed a conditional reelin knockout (RelncKO) mouse to induce postnatal reelin deficiency. Induced reelin deficiency caused dendritic hypertrophy in distal dendritic segments of neuropeptide Y-positive (NPY+) and calretinin-positive (Calr+) interneurons, and in proximal dendritic segments of parvalbumin-positive (Parv+) interneurons. Chronic recombinant Reelin treatment rescued dendritic hypertrophy in Relncko interneurons. Moreover, we provide evidence that RelncKO interneuron hypertrophy is due to presynaptic GABABR dysfunction. Thus, GABABRs in RelncKO interneurons were unable to block N-type (Cav2.2) Ca2+ channels that control neurotransmitter release. Consequently, the excessive Ca2+ influx through AMPA receptors, but not NMDA receptors, caused interneuron dendritic hypertrophy. These findings suggest that reelin acts as a \u2018stop-growth-signal\u2019 for postnatal interneuron maturation.<\/jats:p>","DOI":"10.1242\/dev.199718","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T07:45:14Z","timestamp":1629445514000},"source":"Crossref","is-referenced-by-count":25,"title":["Reelin restricts dendritic growth of interneurons in the neocortex"],"prefix":"10.1242","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0198-389X","authenticated-orcid":false,"given":"Mohammad I. K.","family":"Hamad","sequence":"first","affiliation":[{"name":"Institute for Anatomy and Clinical Morphology, School of Medicine, Faculty of Health, Witten\/Herdecke University, Witten 58455, Germany"},{"name":"Department of Neuroanatomy and Molecular Brain Research, Medical Faculty, Ruhr University Bochum, Bochum 44801, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petya","family":"Petrova","sequence":"additional","affiliation":[{"name":"Department of Neuroanatomy and Molecular Brain Research, Medical Faculty, Ruhr University Bochum, Bochum 44801, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solieman","family":"Daoud","sequence":"additional","affiliation":[{"name":"Department of Neuroanatomy and Molecular Brain Research, Medical Faculty, Ruhr University Bochum, Bochum 44801, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Obada","family":"Rabaya","sequence":"additional","affiliation":[{"name":"Department of Neuroanatomy and Molecular Brain Research, Medical Faculty, Ruhr University Bochum, Bochum 44801, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdalrahim","family":"Jbara","sequence":"additional","affiliation":[{"name":"Department of Neuroanatomy and Molecular Brain Research, Medical Faculty, Ruhr University Bochum, Bochum 44801, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesrine","family":"Melliti","sequence":"additional","affiliation":[{"name":"Department of Neuroanatomy and Molecular Brain Research, Medical Faculty, Ruhr University Bochum, Bochum 44801, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Leifeld","sequence":"additional","affiliation":[{"name":"Department of Neuroanatomy and Molecular Brain Research, Medical Faculty, Ruhr University Bochum, Bochum 44801, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Jakov\u010devski","sequence":"additional","affiliation":[{"name":"Institute for Anatomy and Clinical Morphology, School of Medicine, Faculty of Health, Witten\/Herdecke University, Witten 58455, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gebhard","family":"Reiss","sequence":"additional","affiliation":[{"name":"Institute for Anatomy and Clinical Morphology, School of Medicine, Faculty of Health, Witten\/Herdecke University, Witten 58455, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Herz","sequence":"additional","affiliation":[{"name":"Departments of Molecular Genetics, Neuroscience, Neurology and Neurotherapeutics; Center for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eckart","family":"F\u00f6rster","sequence":"additional","affiliation":[{"name":"Department of Neuroanatomy and Molecular Brain Research, Medical Faculty, Ruhr University Bochum, Bochum 44801, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2021,9,6]]},"reference":[{"key":"2021090609554149500_DEV199718C1","doi-asserted-by":"publisher","first-page":"7779","DOI":"10.1523\/JNEUROSCI.18-19-07779.1998","article-title":"Regional and cellular patterns of reelin mRNA expression in the forebrain of the developing and adult mouse","volume":"18","author":"Alc\u00e1ntara","year":"1998","journal-title":"J. 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