{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:31:24Z","timestamp":1758396684775,"version":"3.41.2"},"reference-count":63,"publisher":"The Company of Biologists","issue":"4","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["207786640 (Ki728\/9-2)","432236295 (Hi 678\/10-1)","171943101 (Ki728\/8-2)","84948123 (Ki 728\/7-2)"],"award-info":[{"award-number":["207786640 (Ki728\/9-2)","432236295 (Hi 678\/10-1)","171943101 (Ki728\/8-2)","84948123 (Ki 728\/7-2)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Horizon 2020 Marie Sk\u0142odowska-Curie","award":["942937","RENALTRACT"],"award-info":[{"award-number":["942937","RENALTRACT"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The contractile phenotype of smooth muscle cells (SMCs) is transcriptionally controlled by a complex of the DNA-binding protein SRF and the transcriptional co-activator MYOCD. The pathways that activate expression of Myocd and of SMC structural genes in mesenchymal progenitors are diverse, reflecting different intrinsic and extrinsic signaling inputs. Taking the ureter as a model, we analyzed whether Notch signaling, a pathway previously implicated in vascular SMC development, also affects visceral SMC differentiation. We show that mice with a conditional deletion of the unique Notch mediator RBPJ in the undifferentiated ureteric mesenchyme exhibit altered ureter peristalsis with a delayed onset, and decreased contraction frequency and intensity at fetal stages. They also develop hydroureter 2 weeks after birth. Notch signaling is required for precise temporal activation of Myocd expression and, independently, for expression of a group of late SMC structural genes. Based on additional expression analyses, we suggest that a mesenchymal JAG1-NOTCH2\/NOTCH3 module regulates visceral SMC differentiation in the ureter in a biphasic and bimodal manner, and that its molecular function differs from that in the vascular system.<\/jats:p>","DOI":"10.1242\/dev.199735","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T13:10:54Z","timestamp":1643721054000},"source":"Crossref","is-referenced-by-count":5,"title":["Notch signaling is a novel regulator of visceral smooth muscle cell differentiation in the murine ureter"],"prefix":"10.1242","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6871-5318","authenticated-orcid":false,"given":"Jennifer","family":"Kurz","sequence":"first","affiliation":[{"name":"Institute of Molecular Biology, Medizinische Hochschule Hannover, 30625 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna-Carina","family":"Weiss","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology, Medizinische Hochschule Hannover, 30625 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hauke","family":"Thiesler","sequence":"additional","affiliation":[{"name":"Institute of Clinical Biochemistry, Medizinische Hochschule Hannover, 30625 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fairouz","family":"Qasrawi","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology, Medizinische Hochschule Hannover, 30625 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Deuper","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology, Medizinische Hochschule Hannover, 30625 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaskiran","family":"Kaur","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology, Medizinische Hochschule Hannover, 30625 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Rudat","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology, Medizinische Hochschule Hannover, 30625 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo H.","family":"L\u00fcdtke","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology, Medizinische Hochschule Hannover, 30625 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Wojahn","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology, Medizinische Hochschule Hannover, 30625 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert","family":"Hildebrandt","sequence":"additional","affiliation":[{"name":"Institute of Clinical Biochemistry, Medizinische Hochschule Hannover, 30625 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark-Oliver","family":"Trowe","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology, Medizinische Hochschule Hannover, 30625 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8154-0257","authenticated-orcid":false,"given":"Andreas","family":"Kispert","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology, Medizinische Hochschule Hannover, 30625 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2022,2,17]]},"reference":[{"key":"2022021714052797900_DEV199735C1","doi-asserted-by":"publisher","first-page":"4918","DOI":"10.1093\/hmg\/ddq426","article-title":"Hydroureternephrosis due to loss of Sox9-regulated smooth muscle cell differentiation of the ureteric mesenchyme","volume":"19","author":"Airik","year":"2010","journal-title":"Hum. 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