{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:23:44Z","timestamp":1766049824740,"version":"3.41.2"},"reference-count":65,"publisher":"The Company of Biologists","issue":"22","license":[{"start":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T00:00:00Z","timestamp":1636934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01DK103785"],"award-info":[{"award-number":["R01DK103785"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010024","name":"Hungarian Science Foundation","doi-asserted-by":"crossref","award":["124740","138664"],"award-info":[{"award-number":["124740","138664"]}],"id":[{"id":"10.13039\/501100010024","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Research, Development and Innovation Office","award":["FIKP-2018"],"award-info":[{"award-number":["FIKP-2018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The enteric nervous system (ENS), which is derived from enteric neural crest cells (ENCCs), represents the neuronal innervation of the intestine. Compromised ENCC migration can lead to Hirschsprung disease, which is characterized by an aganglionic distal bowel. During the craniocaudal migration of ENCCs along the gut, we find that their proliferation is greatest as the ENCC wavefront passes through the ceca, a pair of pouches at the midgut-hindgut junction in avian intestine. Removal of the ceca leads to hindgut aganglionosis, suggesting that they are required for ENS development. Comparative transcriptome profiling of the cecal buds compared with the interceca region shows that the non-canonical Wnt signaling pathway is preferentially expressed within the ceca. Specifically, WNT11 is highly expressed, as confirmed by RNA in situ hybridization, leading us to hypothesize that cecal expression of WNT11 is important for ENCC colonization of the hindgut. Organ cultures using embryonic day 6 avian intestine show that WNT11 inhibits enteric neuronal differentiation. These results reveal an essential role for the ceca during hindgut ENS formation and highlight an important function for non-canonical Wnt signaling in regulating ENCC differentiation.<\/jats:p>","DOI":"10.1242\/dev.199825","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T11:31:51Z","timestamp":1637235111000},"source":"Crossref","is-referenced-by-count":10,"title":["Avian ceca are indispensable for hindgut enteric nervous system development"],"prefix":"10.1242","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6223-5214","authenticated-orcid":false,"given":"Nandor","family":"Nagy","sequence":"first","affiliation":[{"name":"Department of Anatomy, Histology and Embryology, Faculty of Medicine, Semmelweis University, Budapest, 1094, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamas","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Histology and Embryology, Faculty of Medicine, Semmelweis University, Budapest, 1094, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhian","family":"Stavely","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Pediatric Surgery Research Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114,USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktoria","family":"Halasy","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Histology and Embryology, Faculty of Medicine, Semmelweis University, Budapest, 1094, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Soos","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Histology and Embryology, Faculty of Medicine, Semmelweis University, Budapest, 1094, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emoke","family":"Szocs","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Histology and Embryology, Faculty of Medicine, Semmelweis University, Budapest, 1094, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9890-8241","authenticated-orcid":false,"given":"Ryo","family":"Hotta","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Pediatric Surgery Research Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114,USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2039-7717","authenticated-orcid":false,"given":"Hannah","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Pediatric Surgery Research Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114,USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2106-847X","authenticated-orcid":false,"given":"Allan M.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Pediatric Surgery Research Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114,USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"key":"2021112614022043200_DEV199825C1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0091-679X(08)00209-4","article-title":"In situ hybridization analysis of chick embryos in whole-mount and tissue sections","volume":"87","author":"Acloque","year":"2008","journal-title":"Methods Cell Biol."},{"key":"2021112614022043200_DEV199825C2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/aja.1001570203","article-title":"The origin and differentiation of enteric neurons of the intestine of the fowl embryo","volume":"157","author":"Allan","year":"1980","journal-title":"Am. 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