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Mutations in diverse genes are linked to microcephaly, including several with DNA damage repair (DDR) functions; however, it is not well understood how these DDR gene mutations limit brain size. One such gene is TRAIP, which has multiple functions in DDR. We characterized the Drosophila TRAIP homolog nopo, hereafter traip, and found that traip mutants (traip\u2212) have a brain-specific defect in the mushroom body (MB). traip\u2212 MBs were smaller and contained fewer neurons, but no neurodegeneration, consistent with human primary microcephaly. Reduced neuron numbers in traip\u2212 were explained by premature loss of MB neuroblasts (MB-NBs), in part via caspase-dependent cell death. Many traip\u2212 MB-NBs had prominent chromosome bridges in anaphase, along with polyploidy, aneuploidy or micronuclei. Traip localization during mitosis is sufficient for MB development, suggesting that Traip can repair chromosome bridges during mitosis if necessary. Our results suggest that proper brain size is ensured by the recently described role for TRAIP in unloading stalled replication forks in mitosis, which suppresses DNA bridges and premature neural stem cell loss to promote proper neuron number.<\/jats:p>","DOI":"10.1242\/dev.199987","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T15:47:16Z","timestamp":1647532036000},"source":"Crossref","is-referenced-by-count":5,"title":["Traip controls mushroom body size by suppressing mitotic defects"],"prefix":"10.1242","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8673-9217","authenticated-orcid":false,"given":"Ryan S.","family":"O'Neill","sequence":"first","affiliation":[{"name":"Cell and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4194-1072","authenticated-orcid":false,"given":"Nasser M.","family":"Rusan","sequence":"additional","affiliation":[{"name":"Cell and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2022,3,31]]},"reference":[{"key":"2022033110353289400_DEV199987C1","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1093\/genetics\/129.3.783","article-title":"Embryonic head involution and rotation of male terminalia require the Drosophila locus head involution defective","volume":"129","author":"Abbott","year":"1991","journal-title":"Genetics"},{"key":"2022033110353289400_DEV199987C2","doi-asserted-by":"publisher","first-page":"13019","DOI":"10.1038\/s41598-017-12793-7","article-title":"MCPH1, mutated in primary microcephaly, is required for efficient chromosome alignment during mitosis","volume":"7","author":"Arroyo","year":"2017","journal-title":"Sci. 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