{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:09:59Z","timestamp":1790622599549,"version":"4.1.0"},"reference-count":54,"publisher":"The Company of Biologists","issue":"8","license":[{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"crossref","award":["40248"],"award-info":[{"award-number":["40248"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"crossref","award":["ALTF 115-2016"],"award-info":[{"award-number":["ALTF 115-2016"]}],"id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Association Fran\u00e7aise contre les Myopathies","award":["22576"],"award-info":[{"award-number":["22576"]}]},{"DOI":"10.13039\/501100000245","name":"Michael Smith Foundation for Health Research","doi-asserted-by":"crossref","award":["18351"],"award-info":[{"award-number":["18351"]}],"id":[{"id":"10.13039\/501100000245","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100015382","name":"Centre for Blood Research, University Of British Columbia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015382","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["CIHR-FDN-159908"],"award-info":[{"award-number":["CIHR-FDN-159908"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["CIHR-FRN-156235"],"award-info":[{"award-number":["CIHR-FRN-156235"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Eosinophils, best known for their role in anti-parasitic responses, have recently been shown to actively participate in tissue homeostasis and repair. Their regulation must be tightly controlled, as their absence or hyperplasia is associated with chronic disease (e.g. asthma or inflammatory bowel disease). In the context of skeletal muscle, eosinophils play a supportive role after acute damage. Indeed, their depletion leads to strong defects in skeletal muscle regeneration and, in the absence of eosinophil-secreted interleukin (IL) 4 and IL13, fibro-adipogenic progenitors fail to support muscle stem cell proliferation. However, the role of eosinophils in muscular dystrophy remains elusive. Although it has been shown that eosinophils are present in higher numbers in muscles from mdx mice (a mouse model for Duchenne muscular dystrophy), their depletion does not affect muscle histopathology at an early age. Here, we evaluated the impact of hyper-eosinophilia on the development of fibrofatty infiltration in aged mdx mice and found that muscle eosinophilia leads to defects in muscle homeostasis, regeneration and repair, and eventually hastens death.<\/jats:p>","DOI":"10.1242\/dev.200112","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T15:09:37Z","timestamp":1648220977000},"source":"Crossref","is-referenced-by-count":9,"title":["Elevated numbers of infiltrating eosinophils accelerate the progression of Duchenne muscular dystrophy pathology in <i>mdx<\/i> mice"],"prefix":"10.1242","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8059-8756","authenticated-orcid":false,"given":"Marine","family":"Theret","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering, Department of Medical Genetics, University of British Columbia, 2222 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8876-3496","authenticated-orcid":false,"given":"Lucas","family":"Rempel","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Department of Medical Genetics, University of British Columbia, 2222 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Department of Medical Genetics, University of British Columbia, 2222 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Ritso","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Department of Medical Genetics, University of British Columbia, 2222 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin Wei","family":"Tung","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Department of Medical Genetics, University of British Columbia, 2222 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang Fang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Department of Medical Genetics, University of British Columbia, 2222 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melina","family":"Messing","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Department of Medical Genetics, University of British Columbia, 2222 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hughes","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Department of Medical Genetics, University of British Columbia, 2222 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"McNagny","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Department of Medical Genetics, University of British Columbia, 2222 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Rossi","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Department of Medical Genetics, University of British Columbia, 2222 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"key":"2022032514544870700_DEV200112C1","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1084\/jem.20070075","article-title":"Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis","volume":"204","author":"Arnold","year":"2007","journal-title":"J. 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