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In the mammalian secondary palate, a midline epithelial seam (MES) forms between two palatal shelves and must be removed to allow mesenchymal confluence. Abundant apoptosis and cell extrusion support their importance in MES removal. However, genetically disrupting the intrinsic apoptotic regulators BAX and BAK within the MES results in complete loss of cell death and cell extrusion, but successful removal of the MES. Novel static- and live-imaging approaches reveal that the MES is removed through streaming migration of epithelial trails and islands to reach the oral and nasal epithelial surfaces. Epithelial trail cells that express the basal epithelial marker \u0394Np63 begin to express periderm markers, suggesting that migration is concomitant with differentiation. Live imaging reveals anisotropic actomyosin contractility within epithelial trails, and genetic ablation of actomyosin contractility results in dispersion of epithelial collectives and failure of normal MES migration. These findings demonstrate redundancy between cellular mechanisms of morphogenesis, and reveal a crucial and unique form of collective epithelial migration during tissue fusion.<\/jats:p>","DOI":"10.1242\/dev.200181","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T07:00:30Z","timestamp":1653030030000},"source":"Crossref","is-referenced-by-count":24,"title":["A unique form of collective epithelial migration is crucial for tissue fusion in the secondary palate and can overcome loss of epithelial apoptosis"],"prefix":"10.1242","volume":"149","author":[{"given":"Teng","family":"Teng","sequence":"first","affiliation":[{"name":"University of California San Francisco 1 Department of Cell and Tissue Biology , , San Francisco, CA 94143 , USA"},{"name":"University of California San Francisco 2 Program in Craniofacial Biology , , San Francisco, CA 94143 , USA"},{"name":"Institute for Human Genetics, University of California San Francisco 3 , San Francisco, CA 94143 , USA"},{"name":"Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco 4 , San Francisco, CA 94143 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla S.","family":"Teng","sequence":"additional","affiliation":[{"name":"University of California San Francisco 1 Department of Cell and Tissue Biology , , San Francisco, CA 94143 , USA"},{"name":"University of California San Francisco 2 Program in Craniofacial Biology , , San Francisco, CA 94143 , USA"},{"name":"Institute for Human Genetics, University of California San Francisco 3 , San Francisco, CA 94143 , USA"},{"name":"Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco 4 , San Francisco, CA 94143 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9432-510X","authenticated-orcid":false,"given":"Vesa","family":"Kaartinen","sequence":"additional","affiliation":[{"name":"University of Michigan School of Dentistry 5 Department of Biologic and Materials Sciences , , Ann Arbor, MI 48109 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6053-8756","authenticated-orcid":false,"given":"Jeffrey O.","family":"Bush","sequence":"additional","affiliation":[{"name":"University of California San Francisco 1 Department of Cell and Tissue Biology , , San Francisco, CA 94143 , USA"},{"name":"University of California San Francisco 2 Program in Craniofacial Biology , , San Francisco, CA 94143 , USA"},{"name":"Institute for Human Genetics, University of California San Francisco 3 , San Francisco, CA 94143 , USA"},{"name":"Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco 4 , San Francisco, CA 94143 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2022,5,26]]},"reference":[{"key":"2022060913464348500_DEV200181C1","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1369\/jhc.7A7226.2007","article-title":"An improved method for three-dimensional reconstruction of protein expression patterns in intact mouse and chicken embryos and organs","volume":"55","author":"Ahnfelt-R\u00f8nne","year":"2007","journal-title":"J. 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