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Here, we have deleted Ezh1 and Ezh2 alone or simultaneously from mouse oocytes. H3K27me3 was absent in oocytes without Ezh2 alone, while both H3K27me2 and H3K27me3 were absent in Ezh1\/Ezh2 (Ezh1\/2) double knockout (KO) oocytes. The effects of Ezh1\/2 maternal KO were inherited in zygotes and early embryos, in which restoration of H3K27me3 and H3K27me2 was delayed by the loss of Ezh2 alone or of both Ezh1 and Ezh2. However, the ablation of both Ezh1 and Ezh2, but not Ezh1 or Ezh2 alone, led to significantly decreased litter size due to growth retardation post-implantation. Maternal Ezh1\/2 deficiency caused compromised H3K27me3 and pluripotent epiblast cells in late blastocysts, followed by defective embryonic development. By using RNA-seq, we examined crucial developmental genes in maternal Ezh1\/2 KO embryos and identified 80 putatively imprinted genes. Maternal Ezh1\/2-H3K27 methylation is inherited in offspring embryos and has a critical effect on fetal and placental development. Thus, this work sheds light on maternal epigenetic modifications during embryonic development.<\/jats:p>","DOI":"10.1242\/dev.200316","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T08:54:21Z","timestamp":1657184061000},"source":"Crossref","is-referenced-by-count":23,"title":["Maternal Ezh1\/2 deficiency in oocyte delays H3K27me2\/3 restoration and impairs epiblast development responsible for embryonic sub-lethality in mouse"],"prefix":"10.1242","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9501-4725","authenticated-orcid":false,"given":"Yinan","family":"Zhao","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology, Xiamen University 1 , Xiamen, Fujian 361005 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Bai","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University 2 , Shanghai 200092 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Wu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University 2 , Shanghai 200092 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4818-4673","authenticated-orcid":false,"given":"Dan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology, Xiamen University 1 , Xiamen, Fujian 361005 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5987-1287","authenticated-orcid":false,"given":"Mengying","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology, Xiamen University 1 , Xiamen, Fujian 361005 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingpu","family":"Tian","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology, Xiamen University 1 , Xiamen, Fujian 361005 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4164-4238","authenticated-orcid":false,"given":"Jinhua","family":"Lu","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Reproductive Health Research, Medical College of Xiamen University 3 , Xiamen, Fujian 361102 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9865-324X","authenticated-orcid":false,"given":"Haibin","family":"Wang","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Reproductive Health Research, Medical College of Xiamen University 3 , Xiamen, Fujian 361102 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1041-3928","authenticated-orcid":false,"given":"Shaorong","family":"Gao","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University 2 , Shanghai 200092 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongxian","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology, Xiamen University 1 , Xiamen, Fujian 361005 , China"},{"name":"Fujian Provincial Key Laboratory of Reproductive Health Research, Medical College of Xiamen University 3 , Xiamen, Fujian 361102 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2022,8,4]]},"reference":[{"key":"2024061306304656000_DEV200316C1","doi-asserted-by":"publisher","first-page":"2141","DOI":"10.1210\/me.2008-0033","article-title":"Conditional deletion of the retinoblastoma (Rb) gene in ovarian granulosa cells leads to premature ovarian failure","volume":"22","author":"Andreu-Vieyra","year":"2008","journal-title":"Mol. 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