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In this Spotlight, we explore the idea that genetic forms of neurodegenerative disorders might be rooted in neural development. Focusing on Alzheimer's, Parkinson's and Huntington's disease, we first provide a brief overview of the pathology for these diseases. Although neurodegenerative diseases are generally thought of as late-onset diseases, we discuss recent evidence promoting the notion that they might be considered neurodevelopmental disorders. With this view in mind, we consider the suitability of animal models for studying these diseases, highlighting human-specific features of human brain development. We conclude by proposing that one such feature, human-specific regulation of neurogenic time, might be key to understanding the etiology and pathophysiology of human neurodegenerative disease.<\/jats:p>","DOI":"10.1242\/dev.200397","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T12:15:16Z","timestamp":1684152916000},"source":"Crossref","is-referenced-by-count":38,"title":["The brain on time: links between development and neurodegeneration"],"prefix":"10.1242","volume":"150","author":[{"given":"Khadijeh","family":"Shabani","sequence":"first","affiliation":[{"name":"Institut du Cerveau \u2013 Paris Brain Institute \u2013 ICM, Sorbonne Universit\u00e9, Inserm, CNRS, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re , 75013 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9533-4908","authenticated-orcid":false,"given":"Bassem A.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Institut du Cerveau \u2013 Paris Brain Institute \u2013 ICM, Sorbonne Universit\u00e9, Inserm, CNRS, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re , 75013 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2023,5,15]]},"reference":[{"key":"2023051512151036900_DEV200397C1","doi-asserted-by":"publisher","first-page":"e5409","DOI":"10.7759\/cureus.5409","article-title":"Juvenile Parkinson disease","volume":"11","author":"Anwar","year":"2019","journal-title":"Cureus"},{"key":"2023051512151036900_DEV200397C2","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/ncomms1155","article-title":"Neural stem and progenitor cells shorten S-phase on commitment to neuron production","volume":"2","author":"Arai","year":"2011","journal-title":"Nat. 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