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Imaging living, transparent teleost embryos and mammalian stem cell-derived organoids has provided insights into the rearrangements that eye progenitors undergo to adopt such a shape. Molecular and pharmacological interference with these rearrangements has further identified the underlying molecular machineries and the physical forces involved in this morphogenetic process. In this Review, we summarize the resulting scenarios and proposed models that include common and species-specific events. We further discuss how these studies and those in environmentally adapted blind species may shed light on human inborn eye malformations that result from failures in optic cup morphogenesis, including microphthalmia, anophthalmia and coloboma.<\/jats:p>","DOI":"10.1242\/dev.200399","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T03:38:08Z","timestamp":1675049888000},"source":"Crossref","is-referenced-by-count":34,"title":["Optic cup morphogenesis across species and related inborn human eye defects"],"prefix":"10.1242","volume":"150","author":[{"given":"Marcos J.","family":"Cardozo","sequence":"first","affiliation":[{"name":"Centro de Biolog\u00eda Molecular Severo Ochoa, Consejo Superior de Investigaciones Cient\u00edficas-Universidad Aut\u00f3noma de Madrid 1 , c\/ Nicol\u00e1s Cabrera 1, Cantoblanco, Madrid 28049 , Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER) 2 , c\/ Nicol\u00e1s Cabrera 1, Cantoblanco, Madrid 28049 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"S\u00e1nchez-Bustamante","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular Severo Ochoa, Consejo Superior de Investigaciones Cient\u00edficas-Universidad Aut\u00f3noma de Madrid 1 , c\/ Nicol\u00e1s Cabrera 1, Cantoblanco, Madrid 28049 , Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER) 2 , c\/ Nicol\u00e1s Cabrera 1, Cantoblanco, Madrid 28049 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1870-751X","authenticated-orcid":false,"given":"Paola","family":"Bovolenta","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular Severo Ochoa, Consejo Superior de Investigaciones Cient\u00edficas-Universidad Aut\u00f3noma de Madrid 1 , c\/ Nicol\u00e1s Cabrera 1, Cantoblanco, Madrid 28049 , Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER) 2 , c\/ Nicol\u00e1s Cabrera 1, Cantoblanco, Madrid 28049 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2023,1,30]]},"reference":[{"key":"2023013008375601100_DEV200399C1","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0301-0082(00)00042-3","article-title":"Otx genes in brain morphogenesis","volume":"64","author":"Acampora","year":"2001","journal-title":"Prog. 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