{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T23:26:47Z","timestamp":1790465207786,"version":"4.1.0"},"reference-count":49,"publisher":"The Company of Biologists","issue":"11","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/501100014219","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"crossref","award":["81925015"],"award-info":[{"award-number":["81925015"]}],"id":[{"id":"10.13039\/501100014219","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["91649202"],"award-info":[{"award-number":["91649202"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"crossref","award":["XDA16020701"],"award-info":[{"award-number":["XDA16020701"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The sperm flagellum is essential for male fertility, and defects in flagellum biogenesis are associated with male infertility. Deficiency of coiled-coil domain-containing (CCDC) 42 (CCDC42) is specifically associated with malformation of mouse sperm flagella. Here, we find that the testis-specific protein CCDC38 interacts with CCDC42, localizing on the manchette and sperm tail during spermiogenesis. Inactivation of CCDC38 in male mice results in a distorted manchette, multiple morphological abnormalities of the flagella of spermatozoa and eventually male sterility. Furthermore, we find that CCDC38 interacts with intraflagellar transport protein 88 (IFT88), as well as outer dense fibrous 2 (ODF2), and the knockout of Ccdc38 reduces transport of ODF2 to the flagellum. Altogether, our results uncover the essential role of CCDC38 in sperm flagellum biogenesis, and suggest that some mutations of these genes might be associated with male infertility in humans.<\/jats:p>","DOI":"10.1242\/dev.200516","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T10:49:55Z","timestamp":1652957395000},"source":"Crossref","is-referenced-by-count":44,"title":["CCDC38 is required for sperm flagellum biogenesis and male fertility in mice"],"prefix":"10.1242","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4924-8766","authenticated-orcid":false,"given":"Ruidan","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Stem Cell and Regenerative Medicine Innovation Institute, Chinese Academy of Sciences 1 , Beijing 100101 , China"},{"name":"Institute of Reproductive Health and Perinatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University 2 , Guangzhou 510623 , China"},{"name":"University of the Chinese Academy of Sciences 3 , Beijing 100049 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9269-4414","authenticated-orcid":false,"given":"Bingbing","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Stem Cell and Regenerative Medicine Innovation Institute, Chinese Academy of Sciences 1 , Beijing 100101 , China"},{"name":"Institute of Reproductive Health and Perinatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University 2 , Guangzhou 510623 , China"},{"name":"University of the Chinese Academy of Sciences 3 , Beijing 100049 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Stem Cell and Regenerative Medicine Innovation Institute, Chinese Academy of Sciences 1 , Beijing 100101 , China"},{"name":"Institute of Reproductive Health and Perinatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University 2 , Guangzhou 510623 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital 4 Department of Urology , , Beijing 100191 , China"},{"name":"Peking University Third Hospital 5 Department of Andrology , , Beijing 100191 , China"},{"name":"Peking University Third Hospital 6 Department of Reproductive Medicine Center , , Beijing 100191 , China"},{"name":"Peking University Third Hospital 7 Department of Human Sperm Bank , , Beijing 100191 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2268-4680","authenticated-orcid":false,"given":"Xiuge","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Stem Cell and Regenerative Medicine Innovation Institute, Chinese Academy of Sciences 1 , Beijing 100101 , China"},{"name":"University of the Chinese Academy of Sciences 3 , Beijing 100049 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Stem Cell and Regenerative Medicine Innovation Institute, Chinese Academy of Sciences 1 , Beijing 100101 , China"},{"name":"Institute of Reproductive Health and Perinatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University 2 , Guangzhou 510623 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai","family":"Xiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Stem Cell and Regenerative Medicine Innovation Institute, Chinese Academy of Sciences 1 , Beijing 100101 , China"},{"name":"University of the Chinese Academy of Sciences 3 , Beijing 100049 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2169-4673","authenticated-orcid":false,"given":"Yinghong","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Stem Cell and Regenerative Medicine Innovation Institute, Chinese Academy of Sciences 1 , Beijing 100101 , China"},{"name":"University of the Chinese Academy of Sciences 3 , Beijing 100049 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8087-0262","authenticated-orcid":false,"given":"Huafang","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Stem Cell and Regenerative Medicine Innovation Institute, Chinese Academy of Sciences 1 , Beijing 100101 , China"},{"name":"Institute of Reproductive Health and Perinatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University 2 , Guangzhou 510623 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6256-2733","authenticated-orcid":false,"given":"Hui","family":"Jiang","sequence":"additional","affiliation":[{"name":"Peking University Third Hospital 4 Department of Urology , , Beijing 100191 , China"},{"name":"Peking University Third Hospital 5 Department of Andrology , , Beijing 100191 , China"},{"name":"Peking University Third Hospital 6 Department of Reproductive Medicine Center , , Beijing 100191 , China"},{"name":"Peking University Third Hospital 7 Department of Human Sperm Bank , , Beijing 100191 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4415-6165","authenticated-orcid":false,"given":"Fei","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Stem Cell and Regenerative Medicine Innovation Institute, Chinese Academy of Sciences 1 , Beijing 100101 , China"},{"name":"University of the Chinese Academy of Sciences 3 , Beijing 100049 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1816-5618","authenticated-orcid":false,"given":"Li","family":"Yuan","sequence":"additional","affiliation":[{"name":"Savaid Medical School, University of Chinese Academy of Sciences 8 , Beijing 100049 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6235-0749","authenticated-orcid":false,"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Stem Cell and Regenerative Medicine Innovation Institute, Chinese Academy of Sciences 1 , Beijing 100101 , China"},{"name":"Institute of Reproductive Health and Perinatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University 2 , Guangzhou 510623 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2022,6,13]]},"reference":[{"key":"2022061309080210900_DEV200516C1","first-page":"320","article-title":"Outer dense fiber proteins: bridging between male infertility and cancer","volume":"20","author":"Azizi","year":"2017","journal-title":"Arch. Iran. Med."},{"key":"2022061309080210900_DEV200516C2","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1093\/humupd\/dmv020","article-title":"Teratozoospermia: spotlight on the main genetic actors in the human","volume":"21","author":"Coutton","year":"2015","journal-title":"Hum. Reprod. Update"},{"key":"2022061309080210900_DEV200516C3","doi-asserted-by":"publisher","first-page":"4643","DOI":"10.1242\/jcs.01303","article-title":"Outer dense fibre protein 2 (ODF2) is a self-interacting centrosomal protein with affinity for microtubules","volume":"117","author":"Donkor","year":"2004","journal-title":"J. Cell Sci."},{"key":"2022061309080210900_DEV200516C4","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/0012-1606(75)90411-X","article-title":"The mammalian spermatozoon","volume":"44","author":"Fawcett","year":"1975","journal-title":"Dev. Biol."},{"key":"2022061309080210900_DEV200516C5","doi-asserted-by":"publisher","first-page":"4128","DOI":"10.1242\/jcs.157008","article-title":"Proteomic analysis of mammalian sperm cells identifies new components of the centrosome","volume":"127","author":"Firat-Karalar","year":"2014","journal-title":"J. Cell Sci."},{"key":"2022061309080210900_DEV200516C6","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1095\/biolreprod.116.144337","article-title":"Signaling mechanisms in mammalian sperm motility","volume":"96","author":"Freitas","year":"2017","journal-title":"Biol. Reprod."},{"key":"2022061309080210900_DEV200516C49","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1083\/jcb.201801039","article-title":"Interaction of heterotrimeric kinesin-II with IFT-B-connecting tetramer is crucial for ciliogenesis","volume":"217","author":"Funabashi","year":"2018","journal-title":"J. Cell Biol."},{"key":"2022061309080210900_DEV200516C47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1152\/physrev.00013.2015","article-title":"Spermatogenesis: the commitment to meiosis","volume":"96","author":"Griswold","year":"2016","journal-title":"Physiol. Rev."},{"key":"2022061309080210900_DEV200516C7","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1093\/molehr\/gar034","article-title":"Sperm flagella: comparative and phylogenetic perspectives of protein components","volume":"17","author":"Inaba","year":"2011","journal-title":"Mol. Hum. Reprod."},{"key":"2022061309080210900_DEV200516C8","doi-asserted-by":"publisher","first-page":"a021998","DOI":"10.1101\/cshperspect.a021998","article-title":"Intraflagellar transport and ciliary dynamics","volume":"9","author":"Ishikawa","year":"2017","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"2022061309080210900_DEV200516C9","doi-asserted-by":"publisher","first-page":"14249","DOI":"10.1038\/s41598-019-50516-2","article-title":"Odf2 haploinsufficiency causes a new type of decapitated and decaudated spermatozoa, Odf2-Dds, in mice","volume":"9","author":"Ito","year":"2019","journal-title":"Sci. Rep."},{"key":"2022061309080210900_DEV200516C10","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1093\/humupd\/dmaa034","article-title":"Molecular genetics of infertility: loss-of-function mutations in humans and corresponding knockout\/mutated mice","volume":"27","author":"Jiao","year":"2021","journal-title":"Hum. Reprod. Update"},{"key":"2022061309080210900_DEV200516C11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/mrd.10179","article-title":"Intramanchette transport (IMT): managing the making of the spermatid head, centrosome, and tail","volume":"63","author":"Kierszenbaum","year":"2002","journal-title":"Mol. Reprod. Dev."},{"key":"2022061309080210900_DEV200516C12","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1002\/mrd.10164","article-title":"Ran, a GTP-binding protein involved in nucleocytoplasmic transport and microtubule nucleation, relocates from the manchette to the centrosome region during rat spermiogenesis","volume":"63","author":"Kierszenbaum","year":"2002","journal-title":"Mol. Reprod. Dev."},{"key":"2022061309080210900_DEV200516C13","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1530\/jrf.0.1160345","article-title":"Isolation and characterization of rat sperm tail outer dense fibres and comparison with rabbit and human spermatozoa using a polyclonal antiserum","volume":"116","author":"Kim","year":"1999","journal-title":"J. Reprod. Fertil."},{"key":"2022061309080210900_DEV200516C48","doi-asserted-by":"publisher","first-page":"R43","DOI":"10.1530\/REP-15-0310","article-title":"Formation and function of the manchette and flagellum during spermatogenesis","volume":"151","author":"Lehti","year":"2016","journal-title":"Reproduction"},{"key":"2022061309080210900_DEV200516C14","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1093\/biolre\/iox096","article-title":"Formation and function of sperm tail structures in association with sperm motility defects","volume":"97","author":"Lehti","year":"2017","journal-title":"Biol. Reprod."},{"key":"2022061309080210900_DEV200516C15","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1111\/cge.13525","article-title":"DNAH2 is a novel candidate gene associated with multiple morphological abnormalities of the sperm flagella","volume":"95","author":"Li","year":"2019","journal-title":"Clin. Genet."},{"key":"2022061309080210900_DEV200516C16","doi-asserted-by":"publisher","first-page":"e13575","DOI":"10.1111\/and.13575","article-title":"Mutational effect of human CFAP43 splice-site variant causing multiple morphological abnormalities of the sperm flagella","volume":"52","author":"Li","year":"2020","journal-title":"Andrologia"},{"key":"2022061309080210900_DEV200516C17","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.3892\/mmr.2016.5360","article-title":"Identification and characteristics of the testes-specific gene, Ccdc38, in mice","volume":"14","author":"Lin","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"2022061309080210900_DEV200516C18","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1080\/15548627.2016.1159377","article-title":"Autophagy is required for ectoplasmic specialization assembly in sertoli cells","volume":"12","author":"Liu","year":"2016","journal-title":"Autophagy"},{"key":"2022061309080210900_DEV200516C19","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.ajhg.2019.02.020","article-title":"Bi-allelic mutations in TTC21A induce asthenoteratospermia in humans and mice","volume":"104","author":"Liu","year":"2019","journal-title":"Am. J. Hum. Genet."},{"key":"2022061309080210900_DEV200516C20","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.ajhg.2020.06.004","article-title":"Bi-allelic DNAH8 variants lead to multiple morphological abnormalities of the sperm flagella and primary male infertility","volume":"107","author":"Liu","year":"2020","journal-title":"Am. J. Hum. Genet."},{"key":"2022061309080210900_DEV200516C21","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.ydbio.2016.01.042","article-title":"Coiled-coil domain containing 42 (Ccdc42) is necessary for proper sperm development and male fertility in the mouse","volume":"412","author":"Pasek","year":"2016","journal-title":"Dev. Biol."},{"key":"2022061309080210900_DEV200516C22","doi-asserted-by":"publisher","first-page":"5","DOI":"10.4103\/1008-682X.167716","article-title":"Major regulatory mechanisms involved in sperm motility","volume":"19","author":"Pereira","year":"2017","journal-title":"Asian J. Androl."},{"key":"2022061309080210900_DEV200516C23","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1136\/jmedgenet-2011-100457","article-title":"A human laterality disorder associated with recessive CCDC11 mutation","volume":"49","author":"Perles","year":"2012","journal-title":"J. Med. Genet."},{"key":"2022061309080210900_DEV200516C24","doi-asserted-by":"publisher","first-page":"2725","DOI":"10.1007\/s43032-021-00595-2","article-title":"Coiled-coil domain-containing (CCDC) proteins: functional roles in general and male reproductive physiology","volume":"28","author":"Priyanka","year":"2021","journal-title":"Reprod. Sci."},{"key":"2022061309080210900_DEV200516C25","doi-asserted-by":"publisher","first-page":"39318","DOI":"10.1038\/srep39318","article-title":"Deficiency of Mkrn2 causes abnormal spermiogenesis and spermiation, and impairs male fertility","volume":"6","author":"Qian","year":"2016","journal-title":"Sci. Rep."},{"key":"2022061309080210900_DEV200516C26","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1038\/nrm952","article-title":"Intraflagellar transport","volume":"3","author":"Rosenbaum","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2022061309080210900_DEV200516C27","doi-asserted-by":"publisher","first-page":"4358","DOI":"10.1091\/mbc.E15-08-0578","article-title":"Intraflagellar transport is essential for mammalian spermiogenesis but is absent in mature sperm","volume":"26","author":"San Agustin","year":"2015","journal-title":"Mol. Biol. Cell"},{"key":"2022061309080210900_DEV200516C28","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1146\/annurev.cellbio.19.111401.091318","article-title":"Intraflagellar transport","volume":"19","author":"Scholey","year":"2003","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"2022061309080210900_DEV200516C29","doi-asserted-by":"publisher","first-page":"101","DOI":"10.4103\/1008-682X.122192","article-title":"Management of primary ciliary dyskinesia\/Kartagener's syndrome in infertile male patients and current progress in defining the underlying genetic mechanism","volume":"16","author":"Sha","year":"2014","journal-title":"Asian J. Androl."},{"key":"2022061309080210900_DEV200516C30","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.gene.2017.08.033","article-title":"A homozygous CEP135 mutation is associated with multiple morphological abnormalities of the sperm flagella (MMAF)","volume":"633","author":"Sha","year":"2017","journal-title":"Gene"},{"key":"2022061309080210900_DEV200516C31","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1080\/19396368.2019.1655812","article-title":"CCDC9 is identified as a novel candidate gene of severe asthenozoospermia","volume":"65","author":"Sha","year":"2019","journal-title":"Syst. Biol. Reprod. Med."},{"key":"2022061309080210900_DEV200516C32","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/s41467-018-08182-x","article-title":"Loss-of-function mutations in QRICH2 cause male infertility with multiple morphological abnormalities of the sperm flagella","volume":"10","author":"Shen","year":"2019","journal-title":"Nat. Commun."},{"key":"2022061309080210900_DEV200516C33","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1091\/mbc.E15-07-0474","article-title":"Ccdc11 is a novel centriolar satellite protein essential for ciliogenesis and establishment of left-right asymmetry","volume":"27","author":"Silva","year":"2016","journal-title":"Mol. Biol. Cell"},{"key":"2022061309080210900_DEV200516C34","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1007\/s00018-019-03389-7","article-title":"Sperm defects in primary ciliary dyskinesia and related causes of male infertility","volume":"77","author":"Sironen","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"2022061309080210900_DEV200516C35","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.ajhg.2017.04.012","article-title":"Biallelic mutations in CFAP43 and CFAP44 cause male infertility with multiple morphological abnormalities of the sperm flagella","volume":"100","author":"Tang","year":"2017","journal-title":"Am. J. Hum. Genet."},{"key":"2022061309080210900_DEV200516C36","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3389\/fcell.2019.00151","article-title":"CCDC42 localizes to Manchette, HTCA and tail and interacts with ODF1 and ODF2 in the formation of the male germ cell cytoskeleton","volume":"7","author":"Tapia Contreras","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"2022061309080210900_DEV200516C37","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/1471-213X-10-67","article-title":"Gene trap mutation of murine outer dense fiber protein-2 gene can result in sperm tail abnormalities in mice with high percentage chimaerism","volume":"10","author":"Tarnasky","year":"2010","journal-title":"BMC Dev. Biol."},{"key":"2022061309080210900_DEV200516C38","doi-asserted-by":"publisher","first-page":"a028092","DOI":"10.1101\/cshperspect.a028092","article-title":"The intraflagellar transport machinery","volume":"8","author":"Taschner","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"2022061309080210900_DEV200516C39","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1038\/s41418-017-0037-8","article-title":"Dual roles of TRF1 in tethering telomeres to the nuclear envelope and protecting them from fusion during meiosis","volume":"25","author":"Wang","year":"2018","journal-title":"Cell Death Differ."},{"key":"2022061309080210900_DEV200516C40","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.gene.2018.03.059","article-title":"The acroframosome-acroplaxome-manchette axis may function in sperm head shaping and male fertility","volume":"660","author":"Wei","year":"2018","journal-title":"Gene"},{"key":"2022061309080210900_DEV200516C41","doi-asserted-by":"publisher","first-page":"676910","DOI":"10.3389\/fcell.2021.676910","article-title":"Essential role of CFAP53 in sperm flagellum biogenesis","volume":"9","author":"Wu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"2022061309080210900_DEV200516C42","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1369\/0022155413520607","article-title":"Molecular cloning and subcellular localization of Tektin2-binding protein 1 (Ccdc 172) in rat spermatozoa","volume":"62","author":"Yamaguchi","year":"2014","journal-title":"J. Histochem. Cytochem."},{"key":"2022061309080210900_DEV200516C43","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1128\/MCB.06158-11","article-title":"The small heat shock protein ODF1\/HSPB10 is essential for tight linkage of sperm head to tail and male fertility in mice","volume":"32","author":"Yang","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"2022061309080210900_DEV200516C44","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1530\/REP-14-0370","article-title":"Haplo-deficiency of ODF1\/HSPB10 in mouse sperm causes relaxation of head-to-tail linkage","volume":"148","author":"Yang","year":"2014","journal-title":"Reproduction"},{"key":"2022061309080210900_DEV200516C45","doi-asserted-by":"publisher","first-page":"24732","DOI":"10.3390\/ijms161024732","article-title":"CRISPR\/Cas9-mediated rapid generation of multiple mouse lines identified Ccdc63 as essential for spermiogenesis","volume":"16","author":"Young","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"2022061309080210900_DEV200516C46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4103\/aja202183","article-title":"Novel mutation in ODF2 causes multiple morphological abnormalities of the sperm flagella in an infertile male","volume":"24","author":"Zhu","year":"2022","journal-title":"Asian J. Androl."}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.200516\/2145377\/dev200516.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.200516\/2148145\/dev200516.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.200516\/2148145\/dev200516.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T09:08:13Z","timestamp":1655111293000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/149\/11\/dev200516\/275684\/CCDC38-is-required-for-sperm-flagellum-biogenesis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,1]]},"references-count":49,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,6,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.200516","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,1]]},"article-number":"dev200516"}}