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Here, we show that the zinc-finger transcription factor gene Gata6 is expressed in mesenchymal precursors of ureteric SMCs under the control of BMP4 signaling. Mice with a conditional loss of Gata6 in these precursors exhibit a delayed onset and reduced level of SMC differentiation and peristaltic activity, as well as dilatation of the ureter and renal pelvis (hydroureternephrosis) at birth and at postnatal stages. Molecular profiling revealed a delayed and reduced expression of the myogenic driver gene Myocd, but the activation of signaling pathways and transcription factors previously implicated in activation of the visceral SMC program in the ureter was unchanged. Additional gain-of-function experiments suggest that GATA6 cooperates with FOXF1 in Myocd activation and SMC differentiation, possibly as pioneer and lineage-determining factors, respectively.<\/jats:p>","DOI":"10.1242\/dev.200522","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T16:05:04Z","timestamp":1659110704000},"source":"Crossref","is-referenced-by-count":11,"title":["GATA6 is a crucial factor for <i>Myocd<\/i> expression in the visceral smooth muscle cell differentiation program of the murine ureter"],"prefix":"10.1242","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7382-5789","authenticated-orcid":false,"given":"Jennifer","family":"Kurz","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Molekularbiologie, Medizinische Hochschule Hannover 1 , D-30625 Hannover , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Carina","family":"Weiss","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Molekularbiologie, Medizinische Hochschule Hannover 1 , D-30625 Hannover , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo H.-W.","family":"L\u00fcdtke","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Molekularbiologie, Medizinische Hochschule Hannover 1 , D-30625 Hannover , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Deuper","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Molekularbiologie, Medizinische Hochschule Hannover 1 , D-30625 Hannover , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0011-461X","authenticated-orcid":false,"given":"Mark-Oliver","family":"Trowe","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Molekularbiologie, Medizinische Hochschule Hannover 1 , D-30625 Hannover , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hauke","family":"Thiesler","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Klinische Biochemie, Medizinische Hochschule Hannover 2 , D-30625 Hannover , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1044-0881","authenticated-orcid":false,"given":"Herbert","family":"Hildebrandt","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Klinische Biochemie, Medizinische Hochschule Hannover 2 , D-30625 Hannover , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1541-3030","authenticated-orcid":false,"given":"Joerg","family":"Heineke","sequence":"additional","affiliation":[{"name":"European Center for Angioscience, Medizinische Fakult\u00e4t Mannheim, Universit\u00e4t Heidelberg 3 Abteilung f\u00fcr Kardiovaskul\u00e4re Physiologie , , D-68167 Mannheim , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2507-7827","authenticated-orcid":false,"given":"Stephen A.","family":"Duncan","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina 4 Department of Regenerative Medicine and Cell Biology , , Charleston, SC 29425, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8154-0257","authenticated-orcid":false,"given":"Andreas","family":"Kispert","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Molekularbiologie, Medizinische Hochschule Hannover 1 , D-30625 Hannover , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2022,7,29]]},"reference":[{"key":"2022072916033500900_DEV200522C1","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1161\/01.ATV.0000059405.51042.A0","article-title":"GATA-6 is involved in PPAR\u03b3-mediated activation of differentiated phenotype in human vascular smooth muscle cells","volume":"23","author":"Abe","year":"2003","journal-title":"Arterioscler. 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