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Despite increasing knowledge about temporospatial cortical map development and genetic variants linked to neurodevelopmental disorders, when and how sex-biased neural circuit derailment may arise in diseased brain remain unknown. Here, we identify in mice that serotonin uptake transporter (SERT) in non-serotonergic neurons \u2013 hippocampal and prefrontal pyramidal neurons \u2013 confers sex-biased effects specifically during neural circuit development. A set of gradient-patterned CA3 pyramidal neurons transiently express SERT to clear extracellular serotonin, coinciding with hippocampal synaptic circuit establishment. Ablating pyramidal neuron SERT (SERTPyramid\u0394) alters dendritic spine developmental trajectory in the hippocampus, and precipitates sex-biased impairments in long-term activity-dependent hippocampal synaptic plasticity and cognitive behaviors. Transcriptomic analyses identify sex-biased alterations in gene sets associated with autism, dendritic spine structure, synaptic function and male-specific enrichment of dysregulated genes in glial cells in early postnatal SERTPyramid\u0394 hippocampus. Our data suggest that SERT function in these pyramidal neurons underscores a temporal- and brain region-specific regulation of normal sex-dimorphic circuit development and a source for sex-biased vulnerability to cognitive and behavioral impairments.<\/jats:p>\n               <jats:p>This article has an associated \u2018The people behind the papers\u2019 interview.<\/jats:p>","DOI":"10.1242\/dev.200549","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T10:40:12Z","timestamp":1664534412000},"source":"Crossref","is-referenced-by-count":8,"title":["Sex-biased effects on hippocampal circuit development by perinatal SERT expression in CA3 pyramidal neurons"],"prefix":"10.1242","volume":"149","author":[{"given":"Roberto","family":"De Gregorio","sequence":"first","affiliation":[{"name":"Albert Einstein College of Medicine, Bronx 1 Department of Molecular Pharmacology , , NY 10461 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galadu","family":"Subah","sequence":"additional","affiliation":[{"name":"New York Medical College 2 Department of Cell Biology & Anatomy , , Valhalla, NY 10595 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer C.","family":"Chan","sequence":"additional","affiliation":[{"name":"Friedman Brain Institute, Icahn School of Medicine at Mount Sinai 3 Nash Family Department of Neuroscience , , NY 10029 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Speranza","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine 4 Dominick P. Purpura Department of Neuroscience , , Bronx, NY 10461 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Zhang","sequence":"additional","affiliation":[{"name":"New York Medical College 2 Department of Cell Biology & Anatomy , , Valhalla, NY 10595 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarthi","family":"Ramakrishnan","sequence":"additional","affiliation":[{"name":"Friedman Brain Institute, Icahn School of Medicine at Mount Sinai 3 Nash Family Department of Neuroscience , , NY 10029 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Shen","sequence":"additional","affiliation":[{"name":"Friedman Brain Institute, Icahn School of Medicine at Mount Sinai 3 Nash Family Department of Neuroscience , , NY 10029 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Maze","sequence":"additional","affiliation":[{"name":"Friedman Brain Institute, Icahn School of Medicine at Mount Sinai 3 Nash Family Department of Neuroscience , , NY 10029 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patric K.","family":"Stanton","sequence":"additional","affiliation":[{"name":"New York Medical College 2 Department of Cell Biology & Anatomy , , Valhalla, NY 10595 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3828-9335","authenticated-orcid":false,"given":"Ji Y.","family":"Sze","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine, Bronx 1 Department of Molecular Pharmacology , , NY 10461 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"2022103110220590400_DEV200549C1","doi-asserted-by":"publisher","first-page":"417","DOI":"10.3109\/09540261.2010.515205","article-title":"Sex differences in schizophrenia","volume":"22","author":"Abel","year":"2010","journal-title":"Int. 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