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The molecular mechanisms that underpin lymphatic vessel patterning are not fully elucidated and, to date, no global regulator of lymphatic vessel guidance is known. In this study, we identify the transmembrane cell signalling receptor Plexin D1 (Plxnd1) as a negative regulator of both lymphatic vessel guidance and lymphangiogenesis in zebrafish. plxnd1 is expressed in developing lymphatics and is required for the guidance of both the trunk and facial lymphatic networks. Loss of plxnd1 is associated with misguided intersegmental lymphatic vessel growth and aberrant facial lymphatic branches. Lymphatic guidance in the trunk is mediated, at least in part, by the Plxnd1 ligands, Semaphorin 3AA and Semaphorin 3C. Finally, we show that Plxnd1 normally antagonises Vegfr\/Erk signalling to ensure the correct number of facial LECs and that loss of plxnd1 results in facial lymphatic hyperplasia. As a global negative regulator of lymphatic vessel development, the Sema\/Plxnd1 signalling pathway is a potential therapeutic target for treating diseases associated with dysregulated lymphatic growth.<\/jats:p>","DOI":"10.1242\/dev.200560","type":"journal-article","created":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T08:31:32Z","timestamp":1665131492000},"source":"Crossref","is-referenced-by-count":7,"title":["Plexin D1 negatively regulates zebrafish lymphatic development"],"prefix":"10.1242","volume":"149","author":[{"given":"Denver D.","family":"Britto","sequence":"first","affiliation":[{"name":"School of Medical Sciences, University of Auckland 1 Department of Molecular Medicine and Pathology , , Auckland 1023 , New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"He","sequence":"additional","affiliation":[{"name":"Skirball Institute of Biomolecular Medicine, New York University Grossman School of Medicine 2 , New York, NY 10016 , 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Molecular Medicine and Pathology, Faculty of Medical and Health Sciences , , Auckland 1023 , New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7807-2096","authenticated-orcid":false,"given":"Lin","family":"Grimm","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre 4 Organogenesis and Cancer Program , , Melbourne 3000 , Australia"},{"name":"University of Melbourne 5 Sir Peter MacCallum Department of Oncology , , Melbourne 3010 , Australia"},{"name":"University of Melbourne 6 Department of Anatomy and Physiology , , Melbourne 3010 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin D.","family":"Herbert","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, University of Auckland 1 Department of Molecular Medicine and Pathology , , Auckland 1023 , New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn E.","family":"Crosier","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, University of Auckland 1 Department of Molecular Medicine and Pathology , , Auckland 1023 , New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip S.","family":"Crosier","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, University of Auckland 1 Department of Molecular Medicine and Pathology , , Auckland 1023 , New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan K.","family":"Bohlander","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, University of Auckland 1 Department of Molecular Medicine and Pathology , , Auckland 1023 , New Zealand"},{"name":"The University of Auckland 3 Leukaemia and Blood Cancer Research Unit, Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences , , Auckland 1023 , New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin M.","family":"Hogan","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre 4 Organogenesis and Cancer Program , , Melbourne 3000 , Australia"},{"name":"University of Melbourne 5 Sir Peter MacCallum Department of Oncology , , Melbourne 3010 , Australia"},{"name":"University of Melbourne 6 Department of Anatomy and Physiology , , Melbourne 3010 , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Hall","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, University of Auckland 1 Department of Molecular Medicine and Pathology , , Auckland 1023 , New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Torres-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Skirball Institute of Biomolecular Medicine, New York University Grossman School of Medicine 2 , New 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