{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:05:02Z","timestamp":1790805902012,"version":"4.1.0"},"reference-count":52,"publisher":"The Company of Biologists","issue":"17","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007241","name":"Universit\u00e9 Paris-Saclay","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007241","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Institut Professeur Baulieu"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Schwann cells (SCs) migrate along peripheral axons and divide intensively to generate the right number of cells prior to axonal ensheathment; however, little is known regarding the temporal and molecular control of their division and its impact on myelination. We report that Sil, a spindle pole protein associated with autosomal recessive primary microcephaly, is required for temporal mitotic exit of SCs. In sil-deficient cassiopeia (csp\u2212\/\u2212) mutants, SCs fail to radially sort and myelinate peripheral axons. Elevation of cAMP, but not Rac1 activity, in csp\u2212\/\u2212 restores myelin ensheathment. Most importantly, we show a significant decrease in laminin expression within csp\u2212\/\u2212 posterior lateral line nerve and that forcing Laminin 2 expression in csp\u2212\/\u2212 fully restores the ability of SCs to myelinate. Thus, we demonstrate an essential role for timely SC division in mediating laminin expression to orchestrate radial sorting and peripheral myelination in vivo.<\/jats:p>","DOI":"10.1242\/dev.200640","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T09:05:01Z","timestamp":1659949501000},"source":"Crossref","is-referenced-by-count":14,"title":["Timely Schwann cell division drives peripheral myelination <i>in vivo<\/i> via the laminin\/cAMP pathway"],"prefix":"10.1242","volume":"149","author":[{"given":"Aya","family":"Mikdache","sequence":"first","affiliation":[{"name":"U1195, Inserm, University Paris-Saclay , 94276 Le Kremlin Bic\u00eatre , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Jos\u00e9","family":"Boueid","sequence":"additional","affiliation":[{"name":"U1195, Inserm, University Paris-Saclay , 94276 Le Kremlin Bic\u00eatre , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Lesport","sequence":"additional","affiliation":[{"name":"U1195, Inserm, University Paris-Saclay , 94276 Le Kremlin Bic\u00eatre , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Delespierre","sequence":"additional","affiliation":[{"name":"U1195, Inserm, University Paris-Saclay , 94276 Le Kremlin Bic\u00eatre , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Loisel-Duwattez","sequence":"additional","affiliation":[{"name":"U1195, Inserm, University Paris-Saclay , 94276 Le Kremlin Bic\u00eatre , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9810-3627","authenticated-orcid":false,"given":"Cindy","family":"Degerny","sequence":"additional","affiliation":[{"name":"U1195, Inserm, University Paris-Saclay , 94276 Le Kremlin Bic\u00eatre , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4267-4743","authenticated-orcid":false,"given":"Marcel","family":"Tawk","sequence":"additional","affiliation":[{"name":"U1195, Inserm, University Paris-Saclay , 94276 Le Kremlin Bic\u00eatre , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2022,9,5]]},"reference":[{"key":"2022090514195667300_DEV200640C1","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1126\/science.2255914","article-title":"Disruption of the human SCL locus by \u201cillegitimate\" V-(D)-J recombinase activity","volume":"250","author":"Aplan","year":"1990","journal-title":"Science"},{"key":"2022090514195667300_DEV200640C2","doi-asserted-by":"publisher","first-page":"5462","DOI":"10.1128\/mcb.11.11.5462-5469.1991","article-title":"Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia","volume":"11","author":"Aplan","year":"1991","journal-title":"Mol. 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