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Today, we are moving from a purely genetic understanding of cell specification to a model in which genetics codes for layers of physical\u2013mechanical and electrical properties that drive organogenesis such that organ function and morphogenesis are deeply intertwined. This Review provides an up-to-date survey of the extrinsic and intrinsic mechanical forces acting on the embryonic vertebrate gut during development and of their role in all aspects of intestinal morphogenesis: enteric nervous system formation, epithelium structuring, muscle orientation and differentiation, anisotropic growth and the development of myogenic and neurogenic motility. I outline numerous implications of this biomechanical perspective in the etiology and treatment of pathologies, such as short bowel syndrome, dysmotility, interstitial cells of Cajal-related disorders and Hirschsprung disease.<\/jats:p>","DOI":"10.1242\/dev.200765","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T09:58:04Z","timestamp":1660816684000},"source":"Crossref","is-referenced-by-count":24,"title":["Physical organogenesis of the gut"],"prefix":"10.1242","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9713-1511","authenticated-orcid":false,"given":"Nicolas R.","family":"Chevalier","sequence":"first","affiliation":[{"name":"Laboratoire Mati\u00e8re et Syst\u00e8mes Complexes, Universit\u00e9 Paris Cit\u00e9, CNRS UMR 7057 , 10 rue Alice Domon et L\u00e9onie Duquet, 75013 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2022,8,18]]},"reference":[{"key":"2022081813575871700_DEV200765C1","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1038\/ncb2531","article-title":"Metabolic differentiation in the embryonic retina","volume":"14","author":"Agathocleous","year":"2012","journal-title":"Nat. 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