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Using the transgenic Wnt1-Cre2 driver, we inactivated the Hippo signaling components Lats1 and Lats2 in the cranial neuroepithelium of mouse embryos and found that the double conditional knockout (DCKO) of Lats1\/2 resulted in neural tube and craniofacial defects. Lats1\/2 DCKO mutant embryos had microcephaly with delayed and defective neural tube closure. Furthermore, neuroepithelial cell shape and architecture were disrupted within the cranial neural tube in Lats1\/2 DCKO mutants. RNA sequencing of embryonic neural tubes revealed increased TGFB signaling in Lats1\/2 DCKO mutants. Moreover, markers of epithelial-to-mesenchymal transition (EMT) were upregulated in the cranial neural tube. Inactivation of Hippo signaling downstream effectors, Yap and Taz, suppressed neuroepithelial defects, aberrant EMT and TGFB upregulation in Lats1\/2 DCKO embryos, indicating that LATS1\/2 function via YAP and TAZ. Our findings reveal important roles for Hippo signaling in modulating TGFB signaling during neural crest EMT.<\/jats:p>","DOI":"10.1242\/dev.200860","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T06:48:53Z","timestamp":1663656533000},"source":"Crossref","is-referenced-by-count":16,"title":["LATS1\/2 control TGFB-directed epithelial-to-mesenchymal transition in the murine dorsal cranial neuroepithelium through YAP regulation"],"prefix":"10.1242","volume":"149","author":[{"given":"Idaliz M.","family":"Mart\u00ednez Traverso","sequence":"first","affiliation":[{"name":"Baylor College of Medicine 1 Department of Molecular Physiology and Biophysics , , Houston, TX 77030 , USA"},{"name":"Baylor College of Medicine 2 Interdepartmental Graduate Program in Translational Biology and Molecular Medicine , , Houston, TX 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1369-9661","authenticated-orcid":false,"given":"Jeffrey D.","family":"Steimle","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine 1 Department of Molecular Physiology and Biophysics , , Houston, TX 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4697-3874","authenticated-orcid":false,"given":"Xiaolei","family":"Zhao","sequence":"additional","affiliation":[{"name":"McGovern Medical School, The University of Texas Health Science Center at Houston 3 Department of Pediatrics , , Houston, TX 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6874-9331","authenticated-orcid":false,"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"McGovern Medical School, The University of Texas Health Science Center at Houston 3 Department of Pediatrics , , Houston, TX 77030 , USA"},{"name":"Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center and The University of Texas Health Science Center at Houston 4 , Houston, TX 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7842-9857","authenticated-orcid":false,"given":"James F.","family":"Martin","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine 1 Department of Molecular Physiology and Biophysics , , Houston, TX 77030 , USA"},{"name":"Baylor College of Medicine 2 Interdepartmental Graduate Program in Translational Biology and Molecular Medicine , , Houston, TX 77030 , USA"},{"name":"Cardiomyocyte Renewal Laboratory, Texas Heart Institute 5 , Houston, TX 77030 , USA"},{"name":"Center for Organ Repair and Renewal, Baylor College of Medicine 6 , Houston, TX 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2022,9,20]]},"reference":[{"key":"2022092010484595500_DEV200860C1","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1056\/NEJMoa1014379","article-title":"A randomized trial of prenatal versus postnatal repair of myelomeningocele","volume":"364","author":"Adzick","year":"2011","journal-title":"N. 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