{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:02:34Z","timestamp":1790812954986,"version":"4.1.0"},"reference-count":211,"publisher":"The Company of Biologists","issue":"22","funder":[{"name":"Busch Biomedical Grant"},{"DOI":"10.13039\/100000867","name":"Robert Wood Johnson Foundation","doi-asserted-by":"crossref","award":["74260"],"award-info":[{"award-number":["74260"]}],"id":[{"id":"10.13039\/100000867","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"crossref","award":["R01DE030480"],"award-info":[{"award-number":["R01DE030480"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Craniofacial development requires precise spatiotemporal regulation of multiple signaling pathways that crosstalk to coordinate the growth and patterning of the skull with surrounding tissues. Recent insights into these signaling pathways and previously uncharacterized progenitor cell populations have refined our understanding of skull patterning, bone mineralization and tissue homeostasis. Here, we touch upon classical studies and recent advances with an emphasis on developmental and signaling mechanisms that regulate the osteoblast lineage for the calvaria, which forms the roof of the skull. We highlight studies that illustrate the roles of osteoprogenitor cells and cranial suture-derived stem cells for proper calvarial growth and homeostasis. We also discuss genes and signaling pathways that control suture patency and highlight how perturbing the molecular regulation of these pathways leads to craniosynostosis. Finally, we discuss the recently discovered tissue and signaling interactions that integrate skull and cerebrovascular development, and the potential implications for both cerebrospinal fluid hydrodynamics and brain waste clearance in craniosynostosis.<\/jats:p>","DOI":"10.1242\/dev.201017","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T06:21:26Z","timestamp":1669011686000},"source":"Crossref","is-referenced-by-count":19,"title":["Cranium growth, patterning and homeostasis"],"prefix":"10.1242","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5893-1551","authenticated-orcid":false,"given":"Phillip S.","family":"Ang","sequence":"first","affiliation":[{"name":"Rutgers University 1 Department of Cell Biology and Neuroscience , , Piscataway, NJ 08854, USA"},{"name":"University of Chicago Pritzker School of Medicine 2 , Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt J.","family":"Matrongolo","sequence":"additional","affiliation":[{"name":"Rutgers University 1 Department of Cell Biology and Neuroscience , , Piscataway, NJ 08854, USA"},{"name":"Child Health Institute of New Jersey 3 , New Brunswick, NJ 08901, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maeson L.","family":"Zietowski","sequence":"additional","affiliation":[{"name":"University of Chicago Pritzker School of Medicine 2 , Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelby L.","family":"Nathan","sequence":"additional","affiliation":[{"name":"University of Chicago Medicine 4 Laboratory of Craniofacial Biology and Development, Section of Plastic Surgery, Department of Surgery , , Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell R.","family":"Reid","sequence":"additional","affiliation":[{"name":"University of Chicago Medicine 4 Laboratory of Craniofacial Biology and Development, Section of Plastic Surgery, Department of Surgery , , Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1532-3975","authenticated-orcid":false,"given":"Max A.","family":"Tischfield","sequence":"additional","affiliation":[{"name":"Rutgers University 1 Department of Cell Biology and Neuroscience , , Piscataway, NJ 08854, USA"},{"name":"Child Health Institute of New Jersey 3 , New Brunswick, NJ 08901, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2022,11,21]]},"reference":[{"key":"2022112111212152100_DEV201017C1","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/j.1601-6343.2006.00371.x","article-title":"Cellular response to force application at craniofacial sutures","volume":"9","author":"Alaqeel","year":"2006","journal-title":"Orthod. Craniofac. Res."},{"key":"2022112111212152100_DEV201017C2","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1002\/ajpa.22832","article-title":"Antiquity and geographic distribution of cranial modification among the prehistoric groups of Fuego-Patagonia, Chile: Cranial Modification in Fuego-Patagonia","volume":"158","author":"Alfonso-Durrruty","year":"2015","journal-title":"Am. J. Phys. Anthropol."},{"key":"2022112111212152100_DEV201017C3","doi-asserted-by":"publisher","first-page":"4759","DOI":"10.1128\/MCB.01849-07","article-title":"Fibroblast growth factor signaling uses multiple mechanisms to inhibit wnt-induced transcription in osteoblasts","volume":"28","author":"Ambrosetti","year":"2008","journal-title":"Mol. Cell. 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