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However, the gene regulatory network establishing the communications between SCs and germ cells remains unclear. Here, we report that heterogeneous nuclear ribonucleoprotein H1 (hnRNPH1) in SCs is essential for the establishment of crosstalk between SCs and germ cells. Conditional knockout of hnRNPH1 in mouse SCs leads to compromised blood\u2013testis barrier function, delayed meiotic progression, increased germ cell apoptosis, sloughing of germ cells and, eventually, infertility of mice. Mechanistically, we discovered that hnRNPH1 could interact with the splicing regulator PTBP1 in SCs to regulate the pre-mRNA alternative splicing of the target genes functionally related to cell adhesion. Interestingly, we also found hnRNPH1 could cooperate with the androgen receptor, one of the SC-specific transcription factors, to modulate the transcription level of a group of genes associated with the cell\u2013cell junction and EGFR pathway by directly binding to the gene promoters. Collectively, our findings reveal a crucial role for hnRNPH1 in SCs during spermatogenesis and uncover a potential molecular regulatory network involving hnRNPH1 in establishing Sertoli\u2013germ cell crosstalk.<\/jats:p>","DOI":"10.1242\/dev.201040","type":"journal-article","created":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T09:37:47Z","timestamp":1675157867000},"source":"Crossref","is-referenced-by-count":14,"title":["hnRNPH1 establishes Sertoli\u2013germ cell crosstalk through cooperation with PTBP1 and AR, and is essential for male fertility in mice"],"prefix":"10.1242","volume":"150","author":[{"given":"Shenglei","family":"Feng","sequence":"first","affiliation":[{"name":"Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology 1 , Wuhan 430030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6238-8758","authenticated-orcid":false,"given":"Hui","family":"Wen","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology 1 , Wuhan 430030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology 1 , Wuhan 430030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengneng","family":"Xiong","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology 1 , Wuhan 430030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinmei","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology 1 , Wuhan 430030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqian","family":"Gui","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology 1 , Wuhan 430030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Lv","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology 1 , Wuhan 430030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology 1 , Wuhan 430030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xixiang","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology 1 , Wuhan 430030 , China"},{"name":"Laboratory of Animal Center, Huazhong University of Science and Technology 2 , Wuhan 430030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology 1 , Wuhan 430030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1460-7682","authenticated-orcid":false,"given":"Shuiqiao","family":"Yuan","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology 1 , Wuhan 430030 , China"},{"name":"Laboratory of Animal Center, Huazhong University of Science and Technology 2 , Wuhan 430030 , China"},{"name":"Shenzhen Huazhong University of Science and Technology Research Institute 3 , Shenzhen, Guangdong 518057 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2023,1,31]]},"reference":[{"key":"2023013109374034000_DEV201040C1","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/978-1-4939-8766-5_10","article-title":"Chromosome spread analyses of meiotic sex chromosome inactivation","volume":"1861","author":"Alavattam","year":"2018","journal-title":"Methods Mol. 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