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This is driven by a population of highly migratory and proliferative ENCDCs at the wavefront, but the molecular characteristics of these cells are unknown. ENCDCs from the wavefront and the trailing region were isolated and subjected to RNA-seq. Wavefront-ENCDCs were transcriptionally distinct from trailing ENCDCs, and temporal modelling confirmed their relative immaturity. This population of ENCDCs exhibited altered expression of ECM and cytoskeletal genes, consistent with a migratory phenotype. Unlike trailing ENCDCs, the wavefront lacked expression of genes related to neuronal or glial maturation. As wavefront ENCDC genes were associated with migration and developmental immaturity, the genes that remain expressed in later progenitor populations may be particularly pertinent to understanding the maintenance of ENCDC progenitor characteristics. Dusp6 expression was specifically upregulated at the wavefront. Inhibiting DUSP6 activity prevented wavefront colonization of the hindgut, and inhibited the migratory ability of post-colonized ENCDCs from midgut and postnatal neurospheres. These effects were reversed by simultaneous inhibition of ERK signaling, indicating that DUSP6-mediated ERK inhibition is required for ENCDC migration in mouse and chick.<\/jats:p>","DOI":"10.1242\/dev.201090","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T10:06:50Z","timestamp":1676282810000},"source":"Crossref","is-referenced-by-count":21,"title":["A distinct transcriptome characterizes neural crest-derived cells at the migratory wavefront during enteric nervous system development"],"prefix":"10.1242","volume":"150","author":[{"given":"Rhian","family":"Stavely","sequence":"first","affiliation":[{"name":"Pediatric Surgery Research Laboratories, Massachusetts General Hospital, Harvard Medical School 1 Department of Pediatric Surgery , , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5427-5083","authenticated-orcid":false,"given":"Ryo","family":"Hotta","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Research Laboratories, Massachusetts General Hospital, Harvard Medical School 1 Department of Pediatric Surgery , , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5075-1767","authenticated-orcid":false,"given":"Richard A.","family":"Guyer","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Research Laboratories, Massachusetts General Hospital, Harvard Medical School 1 Department of Pediatric Surgery , , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Picard","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Research Laboratories, Massachusetts General Hospital, Harvard Medical School 1 Department of Pediatric Surgery , , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed A.","family":"Rahman","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Research Laboratories, Massachusetts General Hospital, Harvard Medical School 1 Department of Pediatric Surgery , , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith","family":"Omer","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Research Laboratories, Massachusetts General Hospital, Harvard Medical School 1 Department of Pediatric Surgery , , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1660-3303","authenticated-orcid":false,"given":"Adam","family":"Soos","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Semmelweis University 2 Department of Anatomy, Histology and Embryology , , Budapest 1094, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emoke","family":"Szocs","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Semmelweis University 2 Department of Anatomy, Histology and Embryology , , Budapest 1094, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Mueller","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Research Laboratories, Massachusetts General Hospital, Harvard Medical School 1 Department of Pediatric Surgery , , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2106-847X","authenticated-orcid":false,"given":"Allan M.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Research Laboratories, Massachusetts General Hospital, Harvard Medical School 1 Department of Pediatric Surgery , , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6223-5214","authenticated-orcid":false,"given":"Nandor","family":"Nagy","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Semmelweis University 2 Department of Anatomy, Histology and Embryology , , Budapest 1094, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2023,3,6]]},"reference":[{"key":"2023031407343552800_","doi-asserted-by":"publisher","first-page":"W537","DOI":"10.1093\/nar\/gky379","article-title":"The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2018 update","volume":"46","author":"Afgan","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2023031407343552800_","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.ydbio.2013.08.006","article-title":"Enteric neural crest-derived cells promote their migration by modifying their microenvironment through tenascin-C production","volume":"382","author":"Akbareian","year":"2013","journal-title":"Dev. 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