{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T10:09:37Z","timestamp":1787220577811,"version":"build-2736575974"},"reference-count":94,"publisher":"The Company of Biologists","issue":"6","license":[{"start":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:00:00Z","timestamp":1678752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01HL142788"],"award-info":[{"award-number":["R01HL142788"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["T32EB001026"],"award-info":[{"award-number":["T32EB001026"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["1F31HL149148"],"award-info":[{"award-number":["1F31HL149148"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01HL159805"],"award-info":[{"award-number":["R01HL159805"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01HL157879"],"award-info":[{"award-number":["R01HL157879"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01HL156398"],"award-info":[{"award-number":["R01HL156398"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007921","name":"University of Pittsburgh","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007921","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The regenerative capacity of the mammalian heart is poor, with one potential reason being that adult cardiomyocytes cannot proliferate at sufficient levels to replace lost tissue. During development and neonatal stages, cardiomyocytes can successfully divide under injury conditions; however, as these cells mature their ability to proliferate is lost. Therefore, understanding the regulatory programs that can induce post-mitotic cardiomyocytes into a proliferative state is essential to enhance cardiac regeneration. Here, we report that the forkhead transcription factor Foxm1 is required for cardiomyocyte proliferation after injury through transcriptional regulation of cell cycle genes. Transcriptomic analysis of injured zebrafish hearts revealed that foxm1 expression is increased in border zone cardiomyocytes. Decreased cardiomyocyte proliferation and expression of cell cycle genes in foxm1 mutant hearts was observed, suggesting it is required for cell cycle checkpoints. Subsequent analysis of a candidate Foxm1 target gene, cenpf, revealed that this microtubule and kinetochore binding protein is also required for cardiac regeneration. Moreover, cenpf mutants show increased cardiomyocyte binucleation. Thus, foxm1 and cenpf are required for cardiomyocytes to complete mitosis during zebrafish cardiac regeneration.<\/jats:p>","DOI":"10.1242\/dev.201163","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T04:15:21Z","timestamp":1677471321000},"source":"Crossref","is-referenced-by-count":30,"title":["Foxm1 regulates cardiomyocyte proliferation in adult zebrafish after cardiac injury"],"prefix":"10.1242","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4229-0849","authenticated-orcid":false,"given":"Daniel A.","family":"Zuppo","sequence":"first","affiliation":[{"name":"University of Pittsburgh, School of Medicine 1 Department of Developmental Biology , , Pittsburgh, PA 15213 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9055-758X","authenticated-orcid":false,"given":"Maria A.","family":"Missinato","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, School of Medicine 1 Department of Developmental Biology , , Pittsburgh, PA 15213 , USA"},{"name":"Avidity Biosciences, 10578 Science Center Dr. Suite 125 2 , San Diego, CA 92121 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Santana-Santos","sequence":"additional","affiliation":[{"name":"Department of Computational and Systems Biology, University of Pittsburgh, School of Medicine 3 , Pittsburgh, PA 15213 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Li","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, School of Medicine 1 Department of Developmental Biology , , Pittsburgh, PA 15213 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3172-3132","authenticated-orcid":false,"given":"Panayiotis V.","family":"Benos","sequence":"additional","affiliation":[{"name":"Department of Computational and Systems Biology, University of Pittsburgh, School of Medicine 3 , Pittsburgh, PA 15213 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7123-0063","authenticated-orcid":false,"given":"Michael","family":"Tsang","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, School of Medicine 1 Department of Developmental Biology , , Pittsburgh, PA 15213 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2023,3,14]]},"reference":[{"key":"2023031411544525700_","doi-asserted-by":"publisher","first-page":"4026","DOI":"10.1242\/dev.126649","article-title":"Dynamic microRNA-101a and Fosab expression controls zebrafish heart regeneration","volume":"142","author":"Beauchemin","year":"2015","journal-title":"Development"},{"key":"2023031411544525700_","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/248145a0","article-title":"Regeneration of the ventricular myocardium in amphibians","volume":"248","author":"Becker","year":"1974","journal-title":"Nature"},{"key":"2023031411544525700_","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1161\/CIRCRESAHA.119.316167","article-title":"AP-1 Contributes to chromatin accessibility to promote sarcomere disassembly and cardiomyocyte protrusion during Zebrafish heart regeneration","volume":"126","author":"Beisaw","year":"2020","journal-title":"Circ. 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