{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:45:56Z","timestamp":1790189156927,"version":"4.1.0"},"reference-count":75,"publisher":"The Company of Biologists","issue":"8","license":[{"start":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T00:00:00Z","timestamp":1681516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01DK119210"],"award-info":[{"award-number":["R01DK119210"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R21HD106036"],"award-info":[{"award-number":["R21HD106036"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100015498","name":"Innov\u00e1ci\u00f3s \u00e9s Technol\u00f3giai Miniszt\u00e9rium","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100015498","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010024","name":"Hungarian Science Foundation","doi-asserted-by":"crossref","award":["138664"],"award-info":[{"award-number":["138664"]}],"id":[{"id":"10.13039\/501100010024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The gastrointestinal tract is innervated by an intrinsic neuronal network, known as the enteric nervous system (ENS), and by extrinsic axons arising from peripheral ganglia. The nerve of Remak (NoR) is an avian-specific sacral neural crest-derived ganglionated structure that extends from the cloaca to the proximal midgut and, similar to the pelvic plexus, provides extrinsic innervation to the distal intestine. The molecular mechanisms controlling extrinsic nerve fiber growth into the gut is unknown. In vertebrates, CXCR4, a cell-surface receptor for the CXCL12 chemokine, regulates migration of neural crest cells and axon pathfinding. We have employed chimeric tissue recombinations and organ culture assays to study the role of CXCR4 and CXCL12 molecules in the development of colorectal innervation. CXCR4 is specifically expressed in nerve fibers arising from the NoR and pelvic plexus, while CXCL12 is localized to the hindgut mesenchyme and enteric ganglia. Overexpression of CXCL12 results in significantly enhanced axonal projections to the gut from the NoR, while CXCR4 inhibition disrupts nerve fiber extension, supporting a previously unreported role for CXCR4 and CXCL12 signaling in extrinsic innervation of the colorectum.<\/jats:p>","DOI":"10.1242\/dev.201289","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T10:41:01Z","timestamp":1681209661000},"source":"Crossref","is-referenced-by-count":5,"title":["CXCR4 and CXCL12 signaling regulates the development of extrinsic innervation to the colorectum"],"prefix":"10.1242","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1713-5986","authenticated-orcid":false,"given":"Vikt\u00f3ria","family":"Halasy","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Semmelweis University 1 Department of Anatomy, Histology and Embryology , , Budapest 1094 , Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Em\u0151ke","family":"Sz\u0151cs","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Semmelweis University 1 Department of Anatomy, Histology and Embryology , , Budapest 1094 , Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1660-3303","authenticated-orcid":false,"given":"\u00c1d\u00e1m","family":"So\u00f3s","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Semmelweis University 1 Department of Anatomy, Histology and Embryology , , Budapest 1094 , Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Semmelweis University 1 Department of Anatomy, Histology and Embryology , , Budapest 1094 , Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00f3ra","family":"Pecsenye-Fejsz\u00e1k","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Semmelweis University 1 Department of Anatomy, Histology and Embryology , , Budapest 1094 , Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Hotta","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Research Laboratories, Massachusetts General Hospital, Harvard Medical School 2 Department of Pediatric Surgery , , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan M.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Research Laboratories, Massachusetts General Hospital, Harvard Medical School 2 Department of Pediatric Surgery , , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6223-5214","authenticated-orcid":false,"given":"N\u00e1ndor","family":"Nagy","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Semmelweis University 1 Department of Anatomy, Histology and Embryology , , Budapest 1094 , Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2023,4,20]]},"reference":[{"key":"2023042008093825300_DEV201289C1","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S0091-679X(08)00209-4","article-title":"In situ hybridization analysis of chick embryos in whole-mount and tissue sections","volume":"87","author":"Acloque","year":"2008","journal-title":"Methods Cell Biol."},{"key":"2023042008093825300_DEV201289C2","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1023\/A:1022454827533","article-title":"Histochemical, immunohistochemical, and electron microscopy study of the caudal portion of the chicken intestinal nerve of Remak","volume":"23","author":"Aisa","year":"1998","journal-title":"Neurochem. Res."},{"key":"2023042008093825300_DEV201289C3","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.ydbio.2007.02.020","article-title":"Effects of different regions of the developing gut on the migration of enteric neural crest-derived cells: a role for Sema3A, but not Sema3F","volume":"305","author":"Anderson","year":"2007","journal-title":"Dev. Biol."},{"key":"2023042008093825300_DEV201289C4","doi-asserted-by":"publisher","first-page":"3995","DOI":"10.1523\/JNEUROSCI.4631-04.2005","article-title":"The chemokine stromal cell-derived factor-1 regulates the migration of sensory neuron progenitors","volume":"25","author":"Belmadani","year":"2005","journal-title":"J. Neurosci."},{"key":"2023042008093825300_DEV201289C5","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3389\/fncel.2013.00052","article-title":"Chemokines induce axon outgrowth downstream of Hepatocyte Growth Factor and TCF\/\u03b2-catenin signaling","volume":"7","author":"Bhardwaj","year":"2013","journal-title":"Front. Cell Neurosci"},{"key":"2023042008093825300_DEV201289C6","doi-asserted-by":"publisher","first-page":"4335","DOI":"10.1242\/dev.125.21.4335","article-title":"The sacral neural crest contributes neurons and glia to the post-umbilical gut: spatiotemporal analysis of the development of the enteric nervous system","volume":"125","author":"Burns","year":"1998","journal-title":"Development"},{"key":"2023042008093825300_DEV201289C7","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1006\/dbio.1999.9592","article-title":"Sacral neural crest cells colonise aganglionic hindgut in vivo but fail to compensate for lack of enteric ganglia","volume":"219","author":"Burns","year":"2000","journal-title":"Dev. Biol."},{"key":"2023042008093825300_DEV201289C8","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/0925-4773(95)00350-A","article-title":"Organization and development of the tail bud analyzed with the quail-chick chimaera system","volume":"51","author":"Catala","year":"1995","journal-title":"Mech. Dev."},{"key":"2023042008093825300_DEV201289C9","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1523\/JNEUROSCI.23-04-01360.2003","article-title":"A chemokine, SDF-1, reduces the effectiveness of multiple axonal repellents and is required for normal axon pathfinding","volume":"23","author":"Chalasani","year":"2003","journal-title":"J. Neurosci."},{"key":"2023042008093825300_DEV201289C10","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1523\/JNEUROSCI.4132-06.2007","article-title":"Stromal cell-derived factor-1 antagonizes slit\/robo signaling in vivo","volume":"27","author":"Chalasani","year":"2007","journal-title":"J. Neurosci."},{"key":"2023042008093825300_DEV201289C11","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1634\/stemcells.2006-0145","article-title":"Stromal cell-derived factor-1\/CXCR4 signaling modifies the capillary-like organization of human embryonic stem cell-derived endothelium in vitro","volume":"25","author":"Chen","year":"2007","journal-title":"Stem Cells"},{"key":"2023042008093825300_DEV201289C12","doi-asserted-by":"publisher","first-page":"590","DOI":"10.3389\/fnins.2017.00590","article-title":"The role of SDF-1\/CXCR4\/CXCR7 in neuronal regeneration after cerebral ischemia","volume":"11","author":"Cheng","year":"2017","journal-title":"Front. Neurosci."},{"key":"2023042008093825300_DEV201289C13","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1016\/S0960-9822(07)00562-3","article-title":"Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase","volume":"8","author":"Danielian","year":"1998","journal-title":"Curr. Biol."},{"key":"2023042008093825300_DEV201289C15","doi-asserted-by":"publisher","first-page":"757646","DOI":"10.3389\/fnmol.2021.757646","article-title":"TALPID3\/KIAA0586 regulates multiple aspects of neuromuscular patterning during gastrointestinal development in animal models and Human","volume":"14","author":"Delalande","year":"2021","journal-title":"Front. Mol. Neurosci."},{"key":"2023042008093825300_DEV201289C16","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/S0092-8674(02)01135-2","article-title":"Guidance of primordial germ cell migration by the chemokine SDF-1","volume":"111","author":"Doitsidou","year":"2002","journal-title":"Cell"},{"key":"2023042008093825300_DEV201289C17","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1161\/CIRCRESAHA.113.301333","article-title":"Misregulation of SDF1-CXCR4 signaling impairs early cardiac neural crest cell migration leading to conotruncal defects","volume":"113","author":"Escot","year":"2013","journal-title":"Circ. Res."},{"key":"2023042008093825300_DEV201289C18","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1242\/dev.126573","article-title":"Disruption of CXCR4 signaling in pharyngeal neural crest cells causes DiGeorge syndrome-like malformations","volume":"143","author":"Escot","year":"2016","journal-title":"Development"},{"key":"2023042008093825300_DEV201289C19","doi-asserted-by":"publisher","first-page":"11980","DOI":"10.1073\/pnas.1710308114","article-title":"Dual origin of enteric neurons in vagal Schwann cell precursors and the sympathetic neural crest","volume":"114","author":"Espinosa-Medina","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023042008093825300_DEV201289C20","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.ydbio.2016.03.032","article-title":"Clinical aspects of neurointestinal disease: pathophysiology, diagnosis, and treatment","volume":"417","author":"Goldstein","year":"2016","journal-title":"Dev. Biol."},{"key":"2023042008093825300_DEV201289C21","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1002\/aja.1001950404","article-title":"A series of normal stages in the development of the chick embryo. 1951","volume":"195","author":"Hamburger","year":"1992","journal-title":"Dev. Dyn."},{"key":"2023042008093825300_DEV201289C22","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.ydbio.2016.05.017","article-title":"Enteric nervous system development in avian and zebrafish models","volume":"417","author":"Heanue","year":"2016","journal-title":"Dev. Biol."},{"key":"2023042008093825300_DEV201289C23","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1002\/1097-0177(200007)218:3&lt;525::AID-DVDY1003&gt;3.0.CO;2-7","article-title":"Lumbo-sacral neural crest contributes to the avian enteric nervous system independently of vagal neural crest","volume":"218","author":"Hearn","year":"2000","journal-title":"Dev. Dyn."},{"key":"2023042008093825300_DEV201289C24","doi-asserted-by":"publisher","first-page":"e2016409118","DOI":"10.1073\/pnas.2016409118","article-title":"CXCR4\/CXCL12-mediated entrapment of axons at the injury site compromises optic nerve regeneration","volume":"118","author":"Hilla","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023042008093825300_DEV201289C25","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/S0012-1606(03)00136-2","article-title":"Netrins and DCC in the guidance of migrating neural crest-derived cells in the developing bowel and pancreas","volume":"258","author":"Jiang","year":"2003","journal-title":"Dev. Biol."},{"key":"2023042008093825300_DEV201289C26","doi-asserted-by":"publisher","first-page":"dev182543","DOI":"10.1242\/dev.182543","article-title":"Gut innervation and enteric nervous system development: a spatial, temporal and molecular tour de force","volume":"148","author":"Kang","year":"2021","journal-title":"Development"},{"key":"2023042008093825300_DEV201289C27","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1006\/dbio.2000.9886","article-title":"Colonization of the murine hindgut by sacral crest-derived neural precursors: experimental support for an evolutionarily conserved model","volume":"227","author":"Kapur","year":"2000","journal-title":"Dev. Biol."},{"key":"2023042008093825300_DEV201289C28","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1097\/PAS.0000000000000711","article-title":"Histology of the transition zone in hirschsprung disease","volume":"40","author":"Kapur","year":"2016","journal-title":"Am. J. Surg. Pathol."},{"key":"2023042008093825300_DEV201289C29","doi-asserted-by":"publisher","first-page":"13078","DOI":"10.1523\/JNEUROSCI.0892-10.2010","article-title":"CXCR4 controls ventral migration of sympathetic precursor cells","volume":"30","author":"Kasemeier-Kulesa","year":"2010","journal-title":"J. Neurosci."},{"key":"2023042008093825300_DEV201289C30","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1523\/JNEUROSCI.10-05-01626.1990","article-title":"Innervation of the pancreas by neurons in the gut","volume":"10","author":"Kirchgessner","year":"1990","journal-title":"J. Neurosci."},{"key":"2023042008093825300_DEV201289C31","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/BF00178908","article-title":"Peripheral development of the avian vagus nerve with special reference to the morphological innervation of heart and lung","volume":"182","author":"Kuratani","year":"1990","journal-title":"Anat. Embryol."},{"key":"2023042008093825300_DEV201289C77","doi-asserted-by":"publisher","first-page":"2637","DOI":"10.1242\/dev.120.9.2637","article-title":"The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell development","volume":"120","author":"Kurtz","year":"1994","journal-title":"Development"},{"key":"2023042008093825300_DEV201289C32","first-page":"31","article-title":"The migration of neural crest cells to the wall of the digestive tract in avian embryo","volume":"30","author":"Le Douarin","year":"1973","journal-title":"J. Embryol. Exp. Morphol."},{"key":"2023042008093825300_DEV201289C33","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.neuron.2005.08.011","article-title":"A Cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons","volume":"47","author":"Lieberam","year":"2005","journal-title":"Neuron"},{"key":"2023042008093825300_DEV201289C35","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1002\/cne.24801","article-title":"PROX1 is a specific and dynamic marker of sacral neural crest cells in the chicken intestine","volume":"528","author":"Margarido","year":"2020","journal-title":"J. Comp. Neurol."},{"key":"2023042008093825300_DEV201289C36","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1006\/dbio.1999.9405","article-title":"Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4","volume":"213","author":"Mcgrath","year":"1999","journal-title":"Dev. Biol."},{"key":"2023042008093825300_DEV201289C37","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1038\/sj.embor.7400171","article-title":"Efficient production of germline transgenic chickens using lentiviral vectors","volume":"5","author":"Mcgrew","year":"2004","journal-title":"EMBO Rep."},{"key":"2023042008093825300_DEV201289C38","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1053\/j.gastro.2017.10.005","article-title":"Transcription and signaling regulators in developing neuronal subtypes of mouse and human enteric nervous system","volume":"154","author":"Memic","year":"2018","journal-title":"Gastroenterology"},{"key":"2023042008093825300_DEV201289C39","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1002\/dvg.20335","article-title":"A global double-fluorescent Cre reporter mouse","volume":"45","author":"Muzumdar","year":"2007","journal-title":"Genesis"},{"key":"2023042008093825300_DEV201289C40","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/382635a0","article-title":"Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF\/SDF-1","volume":"382","author":"Nagasawa","year":"1996","journal-title":"Nature"},{"key":"2023042008093825300_DEV201289C41","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1006\/smim.1998.0128","article-title":"A novel CXC chemokine PBSF\/SDF-1 and its receptor CXCR4: their functions in development, hematopoiesis and HIV infection","volume":"10","author":"Nagasawa","year":"1998","journal-title":"Semin. Immunol."},{"key":"2023042008093825300_DEV201289C42","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.ydbio.2006.01.032","article-title":"Endothelin-3 regulates neural crest cell proliferation and differentiation in the hindgut enteric nervous system","volume":"293","author":"Nagy","year":"2006","journal-title":"Dev. Biol."},{"key":"2023042008093825300_DEV201289C43","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.semcdb.2017.01.006","article-title":"Enteric nervous system development: a crest cell's journey from neural tube to colon","volume":"66","author":"Nagy","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"key":"2023042008093825300_DEV201289C44","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/dvdy.20933","article-title":"Pelvic plexus contributes ganglion cells to the hindgut enteric nervous system","volume":"236","author":"Nagy","year":"2007","journal-title":"Dev. Dyn."},{"key":"2023042008093825300_DEV201289C45","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1002\/dvdy.23767","article-title":"Immunophenotypic characterization of enteric neural crest cells in the developing avian colorectum","volume":"241","author":"Nagy","year":"2012","journal-title":"Dev. Dyn."},{"key":"2023042008093825300_DEV201289C46","doi-asserted-by":"publisher","first-page":"dev190900","DOI":"10.1242\/dev.190900","article-title":"RET overactivation leads to concurrent Hirschsprung disease and intestinal ganglioneuromas","volume":"147","author":"Nagy","year":"2020","journal-title":"Development"},{"key":"2023042008093825300_DEV201289C47","doi-asserted-by":"publisher","first-page":"dev199825","DOI":"10.1242\/dev.199825","article-title":"Avian ceca are indispensable for hindgut enteric nervous system development","volume":"148","author":"Nagy","year":"2021","journal-title":"Development"},{"key":"2023042008093825300_DEV201289C48","doi-asserted-by":"publisher","first-page":"6691","DOI":"10.1523\/JNEUROSCI.0309-20.2020","article-title":"Mapping of extrinsic innervation of the gastrointestinal tract in the mouse embryo","volume":"40","author":"Niu","year":"2020","journal-title":"J. Neurosci."},{"key":"2023042008093825300_DEV201289C49","first-page":"227","article-title":"Les nerfs extrinsiques de l'intestin chez l'Oiseau. Le neff de Remak","volume":"39","author":"Nolf","year":"1934","journal-title":"Arch. int. Physiol."},{"key":"2023042008093825300_DEV201289C50","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.ydbio.2009.06.031","article-title":"A role for chemokine signaling in neural crest cell migration and craniofacial development","volume":"333","author":"Olesnicky Killian","year":"2009","journal-title":"Dev. Biol."},{"key":"2023042008093825300_DEV201289C51","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1242\/dev.111.3.647","article-title":"Colonization of the post-umbilical bowel by cells derived from the sacral neural crest: direct tracing of cell migration using an intercalating probe and a replication-deficient retrovirus","volume":"111","author":"Pomeranz","year":"1991","journal-title":"Development"},{"key":"2023042008093825300_DEV201289C52","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/nrgastro.2016.107","article-title":"The bowel and beyond: the enteric nervous system in neurological disorders","volume":"13","author":"Rao","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"2023042008093825300_DEV201289C53","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1387\/ijdb.072374rr","article-title":"Stromal-derived factor-1 (SDF-1) expression during early chick development","volume":"52","author":"Rehimi","year":"2008","journal-title":"Int. J. Dev. Biol."},{"key":"2023042008093825300_DEV201289C54","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1002\/dvdy.22288","article-title":"A novel role of CXCR4 and SDF-1 during migration of cloacal muscle precursors","volume":"239","author":"Rehimi","year":"2010","journal-title":"Dev. Dyn."},{"key":"2023042008093825300_DEV201289C55","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/j.cyto.2011.09.014","article-title":"Chemokine-mediated migration of mesencephalic neural crest cells","volume":"56","author":"Rezzoug","year":"2011","journal-title":"Cytokine"},{"key":"2023042008093825300_DEV201289C56","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1146\/annurev-physiol-021317-121515","article-title":"Unexpected roles for the second brain: enteric nervous system as master regulator of bowel function","volume":"81","author":"Schneider","year":"2019","journal-title":"Annu. Rev. Physiol."},{"key":"2023042008093825300_DEV201289C57","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1242\/dev.111.4.857","article-title":"Vital dye labeling demonstrates a sacral neural crest contribution to the enteric nervous system of chick and mouse embryos","volume":"111","author":"Serbedzija","year":"1991","journal-title":"Development"},{"key":"2023042008093825300_DEV201289C58","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.semcdb.2016.01.031","article-title":"Chemotaxis during neural crest migration","volume":"55","author":"Shellard","year":"2016","journal-title":"Semin. Cell. Dev. Biol."},{"key":"2023042008093825300_DEV201289C59","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1006\/dbio.1999.9294","article-title":"Collapsin-1\/semaphorin D is a repellent for chick ganglion of Remak axons","volume":"212","author":"Shepherd","year":"1999","journal-title":"Dev. Biol."},{"key":"2023042008093825300_DEV201289C60","doi-asserted-by":"publisher","first-page":"100916","DOI":"10.1016\/j.bbrep.2021.100916","article-title":"A simple method for quantitating confocal fluorescent images","volume":"25","author":"Shihan","year":"2021","journal-title":"Biochem. Biophys. Rep."},{"key":"2023042008093825300_DEV201289C61","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1002\/ar.a.20349","article-title":"Staging of intestinal development in the chick embryo","volume":"288A","author":"Southwell","year":"2006","journal-title":"Anat. Rec. A. Discov. Mol. Cell. Evol. Biol."},{"key":"2023042008093825300_DEV201289C62","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/0165-1838(96)00061-6","article-title":"Projections of neurons in the intestinal nerve of Remak to the chicken intestine","volume":"61","author":"Suzuki","year":"1996","journal-title":"J. Auton. Nerv. Syst."},{"key":"2023042008093825300_DEV201289C63","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/31261","article-title":"The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract","volume":"393","author":"Tachibana","year":"1998","journal-title":"Nature"},{"key":"2023042008093825300_DEV201289C64","doi-asserted-by":"publisher","first-page":"2810","DOI":"10.1093\/cercor\/bhq027","article-title":"CXCR4 is required for proper regional and laminar distribution of cortical somatostatin-, calretinin-, and neuropeptide Y-expressing GABAergic interneurons","volume":"20","author":"Tanaka","year":"2010","journal-title":"Cereb. Cortex"},{"key":"2023042008093825300_DEV201289C65","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1038\/s41467-021-22146-8","article-title":"Clonal analysis and dynamic imaging identify multipotency of individual Gallus gallus caudal hindbrain neural crest cells toward cardiac and enteric fates","volume":"12","author":"Tang","year":"2021","journal-title":"Nat. Commun."},{"key":"2023042008093825300_DEV201289C66","doi-asserted-by":"publisher","DOI":"10.1101\/2022.05.09.491197","article-title":"Single-cell profiling coupled with lineage analysis reveals distinct sacral neural crest contributions to the developing enteric nervous system","author":"Tang","year":"2022","journal-title":"bioRxiv"},{"key":"2023042008093825300_DEV201289C67","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/BF00848257","article-title":"Evolution of the lumbo-sacral neural crest in the avian embryo: origin and differentiation of the ganglionated nerve of Remak studied in interspecific quail-chick chimaerae","volume":"184","author":"Teillet","year":"1978","journal-title":"Wilhelm Roux's Arch. Dev. Biol."},{"key":"2023042008093825300_DEV201289C68","doi-asserted-by":"publisher","first-page":"9879","DOI":"10.1523\/JNEUROSCI.1239-15.2015","article-title":"Neuronal differentiation in Schwann cell lineage underlies postnatal neurogenesis in the enteric nervous system","volume":"35","author":"Uesaka","year":"2015","journal-title":"J. Neurosci."},{"key":"2023042008093825300_DEV201289C69","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.ydbio.2016.04.016","article-title":"Development of the intrinsic and extrinsic innervation of the gut","volume":"417","author":"Uesaka","year":"2016","journal-title":"Dev. Biol"},{"key":"2023042008093825300_DEV201289C70","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1053\/j.gastro.2011.06.002","article-title":"Analysis of the sacral neural crest cell contribution to the hindgut enteric nervous system in the mouse embryo","volume":"141","author":"Wang","year":"2011","journal-title":"Gastroenterology"},{"key":"2023042008093825300_DEV201289C71","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/0896-6273(91)90067-A","article-title":"Evidence that biological activity of NGF is mediated through a novel subclass of high affinity receptors","volume":"6","author":"Weskamp","year":"1991","journal-title":"Neuron"},{"key":"2023042008093825300_DEV201289C72","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s00418-020-01920-7","article-title":"How to distinguish between different cell lineages sharing common markers using combinations of double in-situ-hybridization and immunostaining in avian embryos: CXCR4-positive mesodermal and neural crest-derived cells","volume":"155","author":"Yahya","year":"2021","journal-title":"Histochem. Cell Biol."},{"key":"2023042008093825300_DEV201289C73","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1002\/cne.901010212","article-title":"The origin of intrinsic ganglia of trunk viscera from vagal neural crest in the chick embryo","volume":"101","author":"Yntema","year":"1954","journal-title":"J. Comp. Neurol."},{"key":"2023042008093825300_DEV201289C74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00441-004-1057-5","article-title":"The location and phenotype of proliferating neural-crest-derived cells in the developing mouse gut","volume":"320","author":"Young","year":"2005","journal-title":"Cell Tissue Res."},{"key":"2023042008093825300_DEV201289C75","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s00429-005-0013-9","article-title":"Expression of chemokine receptor CXCR4 during chick embryo development","volume":"210","author":"Yusuf","year":"2005","journal-title":"Anat. Embryol."},{"key":"2023042008093825300_DEV201289C76","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/31269","article-title":"Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development","volume":"393","author":"Zou","year":"1998","journal-title":"Nature"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.201289\/2790681\/dev201289.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.201289\/2793192\/dev201289.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.201289\/2793192\/dev201289.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T09:34:12Z","timestamp":1681983252000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/150\/8\/dev201289\/307118\/CXCR4-and-CXCL12-signaling-regulates-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,15]]},"references-count":75,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,4,15]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.201289","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,15]]},"article-number":"dev201289"}}