{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:06:23Z","timestamp":1791576383734,"version":"4.3.4"},"reference-count":108,"publisher":"The Company of Biologists","issue":"14","license":[{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["GM122768"],"award-info":[{"award-number":["GM122768"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["F32HD103406"],"award-info":[{"award-number":["F32HD103406"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["T32CA17468"],"award-info":[{"award-number":["T32CA17468"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The transmembrane proteins cdon and boc are implicated in regulating hedgehog signaling during vertebrate development. Recent work showing roles for these genes in axon guidance and neural crest cell migration suggest that cdon and boc may play additional functions in regulating directed cell movements. We use newly generated and existing mutants to investigate a role for cdon and boc in zebrafish neural crest cell migration. We find that single mutant embryos exhibit normal neural crest phenotypes, but that neural crest migration is strikingly disrupted in double cdon;boc mutant embryos. We further show that this migration phenotype is associated with defects in the differentiation of slow-twitch muscle cells, and the loss of a Col1a1a-containing extracellular matrix, suggesting that neural crest defects may be a secondary consequence to defects in mesoderm development. Combined, our data add to a growing literature showing that cdon and boc act synergistically to promote hedgehog signaling during vertebrate development, and suggest that the zebrafish can be used to study the function of hedgehog receptor paralogs.<\/jats:p>","DOI":"10.1242\/dev.201304","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T18:05:11Z","timestamp":1688148311000},"source":"Crossref","is-referenced-by-count":10,"title":["Mutations in <i>cdon<\/i> and <i>boc<\/i> affect trunk neural crest cell migration and slow-twitch muscle development in zebrafish"],"prefix":"10.1242","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6795-0260","authenticated-orcid":false,"given":"Ezra","family":"Lencer","sequence":"first","affiliation":[{"name":"University of Colorado, Anschutz Medical Campus Aurora 1 Department of Cell and Developmental Biology , , CO 80045 , USA"},{"name":"University of Colorado, Anschutz Medical Campus Aurora 2 Department of Craniofacial Biology , , CO 80045 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Addison","family":"Rains","sequence":"additional","affiliation":[{"name":"University of Colorado, Anschutz Medical Campus Aurora 2 Department of Craniofacial Biology , , CO 80045 , USA"},{"name":"University of Colorado, Anschutz Medical Campus Aurora 3 Cell Biology, Stem Cells and Development Graduate Program , , CO 80045 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Binne","sequence":"additional","affiliation":[{"name":"University of Colorado, Anschutz Medical Campus Aurora 2 Department of Craniofacial Biology , , CO 80045 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rytis","family":"Prekeris","sequence":"additional","affiliation":[{"name":"University of Colorado, Anschutz Medical Campus Aurora 1 Department of Cell and Developmental Biology , , CO 80045 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3003-6042","authenticated-orcid":false,"given":"Kristin B.","family":"Artinger","sequence":"additional","affiliation":[{"name":"University of Colorado, Anschutz Medical Campus Aurora 2 Department of Craniofacial Biology , , CO 80045 , USA"},{"name":"University of Minnesota School of Dentistry 4 Department of Diagnostic and Biological Sciences , , Minneapolis , MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2023,7,13]]},"reference":[{"key":"2023071310151394900_DEV201304C1","doi-asserted-by":"publisher","first-page":"e73550","DOI":"10.7554\/eLife.73550","article-title":"Notch controls the cell cycle to define leader versus follower identities during collective cell migration","volume":"11","author":"Alhashem","year":"2022","journal-title":"Elife"},{"key":"2023071310151394900_DEV201304C2","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1101\/gad.1543607","article-title":"The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development","volume":"21","author":"Allen","year":"2007","journal-title":"Genes Dev."},{"key":"2023071310151394900_DEV201304C3","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.devcel.2011.04.018","article-title":"Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function","volume":"20","author":"Allen","year":"2011","journal-title":"Dev. 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