{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:08:16Z","timestamp":1791443296282,"version":"4.3.3"},"reference-count":82,"publisher":"The Company of Biologists","issue":"20","license":[{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R35HL150713"],"award-info":[{"award-number":["R35HL150713"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01HL151522"],"award-info":[{"award-number":["R01HL151522"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R35GM137878"],"award-info":[{"award-number":["R35GM137878"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"crossref","award":["17SDG33660922"],"award-info":[{"award-number":["17SDG33660922"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ohio State University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The eIF4E family of translation initiation factors bind 5\u2032 methylated caps and act as the limiting step for mRNA translation. The canonical eIF4E1A is required for cell viability, yet other related eIF4E families exist and are utilized in specific contexts or tissues. Here, we describe a family called Eif4e1c, for which we find roles during heart development and regeneration in zebrafish. The Eif4e1c family is present in all aquatic vertebrates but is lost in all terrestrial species. A core group of amino acids shared over 500 million years of evolution forms an interface along the protein surface, suggesting that Eif4e1c functions in a novel pathway. Deletion of eif4e1c in zebrafish caused growth deficits and impaired survival in juveniles. Mutants surviving to adulthood had fewer cardiomyocytes and reduced proliferative responses to cardiac injury. Ribosome profiling of mutant hearts demonstrated changes in translation efficiency of mRNA for genes known to regulate cardiomyocyte proliferation. Although eif4e1c is broadly expressed, its disruption had most notable impact on the heart and at juvenile stages. Our findings reveal context-dependent requirements for translation initiation regulators during heart regeneration.<\/jats:p>","DOI":"10.1242\/dev.201376","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T07:03:56Z","timestamp":1684911836000},"source":"Crossref","is-referenced-by-count":17,"title":["The translation initiation factor homolog\n                    <i>eif4e1c<\/i>\n                    regulates cardiomyocyte metabolism and proliferation during heart regeneration"],"prefix":"10.1242","volume":"150","author":[{"given":"Anupama","family":"Rao","sequence":"first","affiliation":[{"name":"The Ohio State University Medical Center 1 Department of Biological Chemistry and Pharmacology , , Columbus, OH 43210 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baken","family":"Lyu","sequence":"additional","affiliation":[{"name":"The Ohio State University Medical Center 1 Department of Biological Chemistry and Pharmacology , , Columbus, OH 43210 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishrat","family":"Jahan","sequence":"additional","affiliation":[{"name":"The Ohio State University Medical Center 1 Department of Biological Chemistry and Pharmacology , , Columbus, OH 43210 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Lubertozzi","sequence":"additional","affiliation":[{"name":"The Ohio State University 2 Department of Molecular Genetics , , Columbus, OH 43210 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Center for RNA Molecular Biology 3 , Department of Biochemistry, School of Medicine , , Cleveland, OH 44106 USA"},{"name":"Case Western Reserve University 3 , Department of Biochemistry, School of Medicine , , Cleveland, OH 44106 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Tedeschi","sequence":"additional","affiliation":[{"name":"Center for RNA Molecular Biology 3 , Department of Biochemistry, School of Medicine , , Cleveland, OH 44106 USA"},{"name":"Case Western Reserve University 3 , Department of Biochemistry, School of Medicine , , Cleveland, OH 44106 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eckhard","family":"Jankowsky","sequence":"additional","affiliation":[{"name":"Center for RNA Molecular Biology 3 , Department of Biochemistry, School of Medicine , , Cleveland, OH 44106 USA"},{"name":"Case Western Reserve University 3 , Department of Biochemistry, School of Medicine , , Cleveland, OH 44106 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5286-5426","authenticated-orcid":false,"given":"Junsu","family":"Kang","sequence":"additional","affiliation":[{"name":"University of Wisconsin-Madison 4 Department of Cell and Regenerative Biology , , Madison, WI 53705 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Carstens","sequence":"additional","affiliation":[{"name":"The Ohio State University 5 Department of Evolution, Ecology, and Organismal Biology , , Columbus, OH 43210 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth D.","family":"Poss","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Duke Regeneration Center, Duke University School of Medicine 6 , Durham, NC 27710 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kedryn","family":"Baskin","sequence":"additional","affiliation":[{"name":"The Ohio State University Medical Center 7 Department of Cell Biology and Physiology , , Columbus, OH 43210 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0800-6189","authenticated-orcid":false,"given":"Joseph Aaron","family":"Goldman","sequence":"additional","affiliation":[{"name":"The Ohio State University Medical Center 1 Department of Biological Chemistry and Pharmacology , , Columbus, OH 43210 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2023,6,12]]},"reference":[{"key":"2023061211443692400_DEV201376C1","doi-asserted-by":"publisher","first-page":"12145","DOI":"10.1016\/S0021-9258(18)63833-5","article-title":"A mammalian translation initiation factor can substitute for its yeast homologue in vivo","volume":"264","author":"Altmann","year":"1989","journal-title":"J. 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