{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:29:35Z","timestamp":1790303375749,"version":"4.1.0"},"reference-count":92,"publisher":"The Company of Biologists","issue":"12","license":[{"start":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:00:00Z","timestamp":1686700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"crossref","award":["310030_208170"],"award-info":[{"award-number":["310030_208170"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008273","name":"Novartis Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008273","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The human heart is poorly regenerative and cardiac tumors are extremely rare. Whether the adult zebrafish myocardium is responsive to oncogene overexpression and how this condition affects its intrinsic regenerative capacity remains unknown. Here, we have established a strategy of inducible and reversible expression of HRASG12V in zebrafish cardiomyocytes. This approach stimulated a hyperplastic cardiac enlargement within 16\u2005days. The phenotype was suppressed by rapamycin-mediated inhibition of TOR signaling. As TOR signaling is also required for heart restoration after cryoinjury, we compared transcriptomes of hyperplastic and regenerating ventricles. Both conditions were associated with upregulation of cardiomyocyte dedifferentiation and proliferation factors, as well as with similar microenvironmental responses, such as deposition of nonfibrillar Collagen XII and recruitment of immune cells. Among the differentially expressed genes, many proteasome and cell-cycle regulators were upregulated only in oncogene-expressing hearts. Preconditioning of the heart with short-term oncogene expression accelerated cardiac regeneration after cryoinjury, revealing a beneficial synergism between both programs. Identification of the molecular bases underlying the interplay between detrimental hyperplasia and advantageous regeneration provides new insights into cardiac plasticity in adult zebrafish.<\/jats:p>","DOI":"10.1242\/dev.201412","type":"journal-article","created":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T11:44:06Z","timestamp":1686743046000},"source":"Crossref","is-referenced-by-count":6,"title":["Parallels between oncogene-driven cardiac hyperplasia and heart regeneration in zebrafish"],"prefix":"10.1242","volume":"150","author":[{"given":"Catherine","family":"Pfefferli","sequence":"first","affiliation":[{"name":"University of Fribourg 1 Department of Biology , , Chemin du Mus\u00e9e 10, 1700 Fribourg , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryl\u00e8ne","family":"Bonvin","sequence":"additional","affiliation":[{"name":"University of Fribourg 1 Department of Biology , , Chemin du Mus\u00e9e 10, 1700 Fribourg , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dogan","family":"Grepper","sequence":"additional","affiliation":[{"name":"University of Fribourg 1 Department of Biology , , Chemin du Mus\u00e9e 10, 1700 Fribourg , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Robatel","sequence":"additional","affiliation":[{"name":"University of Fribourg 1 Department of Biology , , Chemin du Mus\u00e9e 10, 1700 Fribourg , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9sir\u00e9e","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"University of Fribourg 1 Department of Biology , , Chemin du Mus\u00e9e 10, 1700 Fribourg , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi E. L.","family":"Lischer","sequence":"additional","affiliation":[{"name":"University of Bern 2 Interfaculty Bioinformatic Unit , , Baltzerstrasse 6, 3012 Bern , Switzerland"},{"name":"Swiss Institute of Bioinformatics (SIB) 3 , 1015 Lausanne , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9my","family":"Bruggmann","sequence":"additional","affiliation":[{"name":"University of Bern 2 Interfaculty Bioinformatic Unit , , Baltzerstrasse 6, 3012 Bern , Switzerland"},{"name":"Swiss Institute of Bioinformatics (SIB) 3 , 1015 Lausanne , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3881-9284","authenticated-orcid":false,"given":"Anna","family":"Ja\u017awi\u0144ska","sequence":"additional","affiliation":[{"name":"University of Fribourg 1 Department of Biology , , Chemin du Mus\u00e9e 10, 1700 Fribourg , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2023,6,14]]},"reference":[{"key":"2023061906251687500_DEV201412C1","doi-asserted-by":"publisher","first-page":"e92217","DOI":"10.1371\/journal.pone.0092217","article-title":"Spatial and temporal control of transgene expression in zebrafish","volume":"9","author":"Akerberg","year":"2014","journal-title":"PLoS One"},{"key":"2023061906251687500_DEV201412C2","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1073\/pnas.0704963105","article-title":"Genetic dissection of neural circuits by Tol2 transposon-mediated Gal4 gene and enhancer trapping in zebrafish","volume":"105","author":"Asakawa","year":"2008","journal-title":"Proc. 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