{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:49:56Z","timestamp":1787021396786,"version":"build-2736575974"},"reference-count":72,"publisher":"The Company of Biologists","issue":"17","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"crossref","award":["BT\/HRD\/NBA\/38\/04\/2016"],"award-info":[{"award-number":["BT\/HRD\/NBA\/38\/04\/2016"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"crossref","award":["STR\/2019\/000064"],"award-info":[{"award-number":["STR\/2019\/000064"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"crossref","award":["54\/3\/CFP\/GER\/2011-NCD-II"],"award-info":[{"award-number":["54\/3\/CFP\/GER\/2011-NCD-II"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Germ line integrity is crucial for progeny fitness. Organisms deploy the DNA damage response (DDR) signaling to protect the germ line from genotoxic stress, facilitating the cell-cycle arrest of germ cells and DNA repair or their apoptosis. Cell-autonomous regulation of germ line quality in response to DNA damage is well studied; however, how quality is enforced cell non-autonomously on sensing somatic DNA damage is less known. Using Caenorhabditis elegans, we show that DDR disruption, only in the uterus, when insulin\/IGF-1 signaling (IIS) is low, arrests oogenesis in the pachytene stage of meiosis I, in a FOXO\/DAF-16 transcription factor-dependent manner. Without FOXO\/DAF-16, germ cells of the IIS mutant escape the arrest to produce poor-quality oocytes, showing that the transcription factor imposes strict quality control during low IIS. Activated FOXO\/DAF-16 senses DDR perturbations during low IIS to lower ERK\/MPK-1 signaling below a threshold to promote germ line arrest. Altogether, we elucidate a new surveillance role for activated FOXO\/DAF-16 that ensures optimal germ cell quality and progeny fitness in response to somatic DNA damage.<\/jats:p>","DOI":"10.1242\/dev.201472","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T05:43:35Z","timestamp":1691991815000},"source":"Crossref","is-referenced-by-count":8,"title":["DNA damage signals from somatic uterine tissue arrest oogenesis through activated DAF-16"],"prefix":"10.1242","volume":"150","author":[{"given":"Gautam Chandra","family":"Sarkar","sequence":"first","affiliation":[{"name":"National Institute of Immunology Molecular Aging Laboratory , , Aruna Asaf Ali Marg, New Delhi 110067 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umanshi","family":"Rautela","sequence":"additional","affiliation":[{"name":"National Institute of Immunology Molecular Aging Laboratory , , Aruna Asaf Ali Marg, New Delhi 110067 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Goyala","sequence":"additional","affiliation":[{"name":"National Institute of Immunology Molecular Aging Laboratory , , Aruna Asaf Ali Marg, New Delhi 110067 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudeshna","family":"Datta","sequence":"additional","affiliation":[{"name":"National Institute of Immunology Molecular Aging Laboratory , , Aruna Asaf Ali Marg, New Delhi 110067 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7311-2343","authenticated-orcid":false,"given":"Nikhita","family":"Anand","sequence":"additional","affiliation":[{"name":"National Institute of Immunology Molecular Aging Laboratory , , Aruna Asaf Ali Marg, New Delhi 110067 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupama","family":"Singh","sequence":"additional","affiliation":[{"name":"National Institute of Immunology Molecular Aging Laboratory , , Aruna Asaf Ali Marg, New Delhi 110067 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9890-6051","authenticated-orcid":false,"given":"Prachi","family":"Singh","sequence":"additional","affiliation":[{"name":"National Institute of Immunology Molecular Aging Laboratory , , Aruna Asaf Ali Marg, New Delhi 110067 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0339-7894","authenticated-orcid":false,"given":"Manish","family":"Chamoli","sequence":"additional","affiliation":[{"name":"National Institute of Immunology Molecular Aging Laboratory , , Aruna Asaf Ali Marg, New Delhi 110067 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5266-7849","authenticated-orcid":false,"given":"Arnab","family":"Mukhopadhyay","sequence":"additional","affiliation":[{"name":"National Institute of Immunology Molecular Aging Laboratory , , Aruna Asaf Ali Marg, New Delhi 110067 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2023,9,12]]},"reference":[{"key":"2023091213424957900_DEV201472C1","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1093\/humupd\/dmn063","article-title":"The current knowledge on radiosensitivity of ovarian follicle development stages","volume":"15","author":"Adriaens","year":"2009","journal-title":"Hum. 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