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RNA analysis revealed that ovarian-specific genes, including Foxl2, were ectopically expressed in DT-treated Tg testis explants initiated at embryonic days 12.5-13.5. FOXL2-positive cells were ectopically observed in two testicular regions: near the testicular surface epithelia and around its adjacent mesonephros. The surface FOXL2-positive cells, together with ectopic expression of Lgr5 and Gng13 (markers of ovarian cords), were derived from the testis epithelia\/subepithelia, whereas another FOXL2-positive population was the 3\u03b2HSD-negative stroma near the mesonephros. In addition to high expression of Fgfr1\/Fgfr2 and heparan sulfate proteoglycan (a reservoir for FGF ligand) in these two sites, exogenous FGF9 additives repressed DT-dependent Foxl2 upregulation in Tg testes. These findings imply retention of Foxl2 inducibility in the surface epithelia and peri-mesonephric stroma of the testicular parenchyma, in which certain paracrine signals, including FGF9 derived from fetal Sertoli cells, repress feminization in these two sites of the early fetal testis.<\/jats:p>","DOI":"10.1242\/dev.201660","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T07:25:06Z","timestamp":1687937106000},"source":"Crossref","is-referenced-by-count":7,"title":["Partial male-to-female reprogramming of mouse fetal testis by Sertoli cell ablation"],"prefix":"10.1242","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1668-4518","authenticated-orcid":false,"given":"Kenya","family":"Imaimatsu","sequence":"first","affiliation":[{"name":"The University of Tokyo Department of Veterinary Anatomy , , Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2217-6261","authenticated-orcid":false,"given":"Ryuji","family":"Hiramatsu","sequence":"additional","affiliation":[{"name":"The University of Tokyo Department of Veterinary Anatomy , , Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3500-9147","authenticated-orcid":false,"given":"Ayako","family":"Tomita","sequence":"additional","affiliation":[{"name":"The University of Tokyo Department of Veterinary Anatomy , , Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2642-228X","authenticated-orcid":false,"given":"Hirotsugu","family":"Itabashi","sequence":"additional","affiliation":[{"name":"The University of Tokyo Department of Veterinary Anatomy , , Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2116-7806","authenticated-orcid":false,"given":"Yoshiakira","family":"Kanai","sequence":"additional","affiliation":[{"name":"The University of Tokyo Department of Veterinary Anatomy , , Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2023,7,17]]},"reference":[{"key":"2023071708052090800_DEV201660C1","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1242\/dev.129.5.1155","article-title":"Sexually dimorphic development of mouse primordial germ cells: switching from oogenesis to spermatogenesis","volume":"129","author":"Adams","year":"2002","journal-title":"Development"},{"key":"2023071708052090800_DEV201660C2","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1006\/dbio.2001.0438","article-title":"Evidence that Sry is expressed in pre-sertoli cells and sertoli and granulosa cells have a common precursor","volume":"240","author":"Albrecht","year":"2001","journal-title":"Dev. 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