{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:49:54Z","timestamp":1792698594204,"version":"4.5.0"},"reference-count":183,"publisher":"The Company of Biologists","issue":"22","funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["GNT1194345"],"award-info":[{"award-number":["GNT1194345"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004752","name":"State Government of Victoria","doi-asserted-by":"crossref","award":["9000719"],"award-info":[{"award-number":["9000719"]}],"id":[{"id":"10.13039\/501100004752","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>In mammals, the second X chromosome in females is silenced to enable dosage compensation between XX females and XY males. This essential process involves the formation of a dense chromatin state on the inactive X (Xi) chromosome. There is a wealth of information about the hallmarks of Xi chromatin and the contribution each makes to silencing, leaving the tantalising possibility of learning from this knowledge to potentially remove silencing to treat X-linked diseases in females. Here, we discuss the role of each chromatin feature in the establishment and maintenance of the silent state, which is of crucial relevance for such a goal.<\/jats:p>","DOI":"10.1242\/dev.201742","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T10:13:52Z","timestamp":1700648032000},"source":"Crossref","is-referenced-by-count":10,"title":["Chromatin-mediated silencing on the inactive X chromosome"],"prefix":"10.1242","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4061-9540","authenticated-orcid":false,"given":"Andrew","family":"Keniry","sequence":"first","affiliation":[{"name":"Epigenetics and Development Division, The Walter and Eliza Hall Institute for Medical Research 1 , 1G Royal Parade, Parkville, VIC 3052 , Australia"},{"name":"University of Melbourne 2 The Department of Medical Biology , , Parkville, VIC 3010 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2984-1474","authenticated-orcid":false,"given":"Marnie E.","family":"Blewitt","sequence":"additional","affiliation":[{"name":"Epigenetics and Development Division, The Walter and Eliza Hall Institute for Medical Research 1 , 1G Royal Parade, Parkville, VIC 3052 , Australia"},{"name":"University of Melbourne 2 The Department of Medical Biology , , Parkville, VIC 3010 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2023,11,22]]},"reference":[{"key":"2024061306354708700_DEV201742C1","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s13072-018-0219-8","article-title":"Perturbed maintenance of transcriptional repression on the inactive X-chromosome in the mouse brain after Xist deletion","volume":"11","author":"Adrianse","year":"2018","journal-title":"Epigenetics Chromatin"},{"key":"2024061306354708700_DEV201742C2","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1038\/s41586-022-04537-z","article-title":"Targeting Xist with compounds that disrupt RNA structure and X inactivation","volume":"604","author":"Aguilar","year":"2022","journal-title":"Nature"},{"key":"2024061306354708700_DEV201742C3","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1126\/science.aal2512","article-title":"PCGF3\/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation","volume":"356","author":"Almeida","year":"2017","journal-title":"Science"},{"key":"2024061306354708700_DEV201742C4","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.gde.2020.02.023","article-title":"The many faces of Polycomb regulation by RNA","volume":"61","author":"Almeida","year":"2020","journal-title":"Curr. 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