{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:45:55Z","timestamp":1791499555883,"version":"4.3.4"},"reference-count":103,"publisher":"The Company of Biologists","issue":"19","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"crossref","award":["LUAUS23236"],"award-info":[{"award-number":["LUAUS23236"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>N6-methyl adenosine (m6A) is a widespread internal mRNA modification impacting the expression of numerous genes. Here, we characterize auxin-related defects among the pleiotropic phenotypes of hypomorphic Arabidopsis thaliana mutants with impaired m6A status and reveal that they show strong resistance to exogenously applied auxin. By combining major published m6A datasets, we propose that among high-confidence target transcripts emerge those encoding the main components required for auxin signaling, including the TIR1\/AFB auxin receptors and ARF transcriptional regulators. We also observe subtle changes in endogenous levels of indole-3-acetic acid metabolites in these hypomorphic lines, which correlate with the methylation status of indole-3-acetic acid amidohydrolase transcripts. In addition, we reveal that reduced m6A levels lead to defects in endodermal patterning in the primary root arising from impaired timing of periclinal cell divisions. These defects can be reverted by inhibition of auxin signaling. Together, our data underline that m6A likely affects auxin-dependent processes at multiple levels.<\/jats:p>","DOI":"10.1242\/dev.201775","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T09:25:51Z","timestamp":1695115551000},"source":"Crossref","is-referenced-by-count":11,"title":["<i>N6<\/i>-adenosine methylation of mRNA integrates multilevel auxin response and ground tissue development in <i>Arabidopsis<\/i>"],"prefix":"10.1242","volume":"150","author":[{"given":"Elena A.","family":"Zemlyanskaya","sequence":"first","affiliation":[{"name":"Institute of Experimental Botany, The Czech Academy of Sciences 1 Laboratory of Hormonal Regulations in Plants , , Rozvojov\u00e1 263, CZ-160 00 Prague , Czech Republic"},{"name":"Central European Institute of Technology, Masaryk University 2 Department of Functional Genomics and Proteomics , , Kamenice 25, Brno CZ-62500 , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viacheslav","family":"Zemlianski","sequence":"additional","affiliation":[{"name":"Charles University 3 Faculty of Science , , Vini\u010dn\u00e1 1594\/7, CZ-128 00 Prague , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ale\u0161","family":"P\u011bn\u010d\u00edk","sequence":"additional","affiliation":[{"name":"Palack\u00fd University and Institute of Experimental Botany, The Czech Academy of Sciences 4 Laboratory of Growth Regulators, Faculty of Science , , \u0160lechtitel\u016f 27, CZ-78371 Olomouc , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9186-4186","authenticated-orcid":false,"given":"Dior R.","family":"Kelley","sequence":"additional","affiliation":[{"name":"Iowa State University of Science and Technology 5 Department of Genetics, Development and Cell Biology , , 3011 Advanced Teaching & Research Building, Ames, IA 50011-3220 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yk\u00e4","family":"Helariutta","sequence":"additional","affiliation":[{"name":"Wood Development Group, Institute of Biotechnology 6 , Faculty of Biological and Environmental Sciences , , 00014 Helsinki , Finland"},{"name":"University of Helsinki 6 , Faculty of Biological and Environmental Sciences , , 00014 Helsinki , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ond\u0159ej","family":"Nov\u00e1k","sequence":"additional","affiliation":[{"name":"Palack\u00fd University and Institute of Experimental Botany, The Czech Academy of Sciences 4 Laboratory of Growth Regulators, Faculty of Science , , \u0160lechtitel\u016f 27, CZ-78371 Olomouc , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0602-2046","authenticated-orcid":false,"given":"Kamil","family":"R\u016f\u017ei\u010dka","sequence":"additional","affiliation":[{"name":"Institute of Experimental Botany, The Czech Academy of Sciences 1 Laboratory of Hormonal Regulations in Plants , , Rozvojov\u00e1 263, CZ-160 00 Prague , Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2023,10,2]]},"reference":[{"key":"2024061306354167900_DEV201775C1","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/ncb1369","article-title":"Intracellular trafficking and proteolysis of the Arabidopsis auxin-efflux facilitator PIN2 are involved in root gravitropism","volume":"8","author":"Abas","year":"2006","journal-title":"Nat. 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