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However, endothelin signaling also plays crucial roles in the development of neural crest cell-derived tissues. Mechanisms of endothelin action during neural crest cell maturation have been deciphered using a variety of in vivo and in vitro approaches, with these studies elucidating the basis of human syndromes involving developmental differences resulting from altered endothelin signaling. In this Review, we describe the endothelin pathway and its functions during the development of neural crest-derived tissues. We also summarize how dysregulated endothelin signaling causes developmental differences and how this knowledge may lead to potential treatments for individuals with gene variants in the endothelin pathway.<\/jats:p>","DOI":"10.1242\/dev.201786","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T07:15:37Z","timestamp":1702278937000},"source":"Crossref","is-referenced-by-count":32,"title":["Endothelin signaling in development"],"prefix":"10.1242","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9074-0624","authenticated-orcid":false,"given":"Stanley M.","family":"Kanai","sequence":"first","affiliation":[{"name":"University of Colorado Anschutz Medical Campus Department of Craniofacial Biology , , Aurora, CO 80045 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2008-477X","authenticated-orcid":false,"given":"David E.","family":"Clouthier","sequence":"additional","affiliation":[{"name":"University of Colorado Anschutz Medical Campus Department of Craniofacial Biology , , Aurora, CO 80045 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2023,12,11]]},"reference":[{"key":"2023121112153327000_DEV201786C1","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1146\/annurev.cellbio.23.090506.123331","article-title":"Heart field: from mesoderm to heart tube","volume":"23","author":"Abu-Issa","year":"2007","journal-title":"Annu. 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