{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T12:54:27Z","timestamp":1774097667959,"version":"3.50.1"},"reference-count":70,"publisher":"The Company of Biologists","issue":"21","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/100004897","name":"Pennsylvania Department of Health","doi-asserted-by":"crossref","award":["1472409"],"award-info":[{"award-number":["1472409"]}],"id":[{"id":"10.13039\/100004897","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008321","name":"Pennsylvania State University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008321","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Spermatogenesis begins when cell fate-committed prospermatogonia migrate to the basement membrane and initiate spermatogenesis in response to retinoic acid (RA) in the neonatal testis. The underlying cellular and molecular mechanisms in this process are not fully understood. Here, we report findings on the involvement of a cancer\/testis antigen, PRAMEL1, in the initiation and maintenance of spermatogenesis. By analyzing mouse models with either global or conditional Pramel1 inactivation, we found that PRAMEL1 regulates the RA responsiveness of the subtypes of prospermatogonia in the neonatal testis, and affects their homing process during the initiation of spermatogenesis. Pramel1 deficiency led to increased fecundity in juvenile males and decreased fecundity in mature males. In addition, Pramel1 deficiency resulted in a regional Sertoli cell-only phenotype during the first round of spermatogenesis, which was rescued by administration of the RA inhibitor WIN18,446, suggesting that PRAMEL1 functions as an inhibitor of RA signaling in germ cells. Overall, our findings suggest that PRAMEL1 fine-tunes RA signaling, playing a crucial role in the proper establishment of the first and subsequent rounds of spermatogenesis.<\/jats:p>","DOI":"10.1242\/dev.201907","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T09:51:02Z","timestamp":1696240262000},"source":"Crossref","is-referenced-by-count":3,"title":["Mouse <i>Pramel1<\/i> regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis"],"prefix":"10.1242","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8897-4170","authenticated-orcid":false,"given":"Mingyao","family":"Yang","sequence":"first","affiliation":[{"name":"Center for Reproductive Biology and Health (CRBH), College of Agricultural Sciences, The Pennsylvania State University, 1 Department of Animal Science , University Park, PA 16803, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3638-817X","authenticated-orcid":false,"given":"Wenzhi","family":"Ma","sequence":"additional","affiliation":[{"name":"Center for Reproductive Biology and Health (CRBH), College of Agricultural Sciences, The Pennsylvania State University, 1 Department of Animal Science , University Park, PA 16803, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6692-4351","authenticated-orcid":false,"given":"Jon","family":"Oatley","sequence":"additional","affiliation":[{"name":"Center for Reproductive Biology, School of Molecular Biosciences, College of Veterinary Medicine, Washington State University 2 , Pullman, WA 99164, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1788-7093","authenticated-orcid":false,"given":"Wan-Sheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Reproductive Biology and Health (CRBH), College of Agricultural Sciences, The Pennsylvania State University, 1 Department of Animal Science , University Park, PA 16803, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2023,10,27]]},"reference":[{"key":"2023102614122023000_DEV201907C1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/cancers11070984","article-title":"Cancer testis antigens and immunotherapy: Where do we stand in the targeting of PRAME?","volume":"11","author":"Al-Khadairi","year":"2019","journal-title":"Cancers (Basel)"},{"key":"2023102614122023000_DEV201907C2","doi-asserted-by":"publisher","first-page":"14976","DOI":"10.1073\/pnas.0807297105","article-title":"Stra8 and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in mice","volume":"105","author":"Anderson","year":"2008","journal-title":"Proc. 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A.\n           (2014). Y-box protein 2 (YBX2) is a major mRMA specific regulator of translation in spermatogenesis and the translational regulation of the sperm mitochondria associated cysteine rich protein (Smcp) mRNA. PhD thesis, University of Massachusetts Boston, Boston, MA."},{"key":"2023102614122023000_DEV201907C10","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1152\/physrev.1972.52.1.198","article-title":"Kinetics of spermatogenesis in mammals: seminiferous epithelium cycle and spermatogonial renewal","volume":"52","author":"Clermont","year":"1972","journal-title":"Physiol. Rev."},{"key":"2023102614122023000_DEV201907C11","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1002\/aja.1001000205","article-title":"Quantitative study of the cell population of the seminiferous tubules in immature rats","volume":"80","author":"Clermont","year":"1985","journal-title":"Am. J. Anat."},{"key":"2023102614122023000_DEV201907C12","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/S0014-5793(03)01341-3","article-title":"Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte","volume":"555","author":"Dad\u00e9","year":"2003","journal-title":"FEBS Lett."},{"key":"2023102614122023000_DEV201907C13","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.bbalip.2011.09.014","article-title":"The retinoid X receptors and their ligands","volume":"1821","author":"Dawson","year":"2012","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. 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