{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:55:26Z","timestamp":1791561326720,"version":"4.3.4"},"reference-count":36,"publisher":"The Company of Biologists","issue":"2","license":[{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 DE022503"],"award-info":[{"award-number":["R01 DE022503"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 DE012711"],"award-info":[{"award-number":["R01 DE012711"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Nerves play important roles in organ development and tissue homeostasis. Stem\/progenitor cells differentiate into different cell lineages responsible for building the craniofacial organs. The mechanism by which nerves regulate stem\/progenitor cell behavior in organ morphogenesis has not yet been comprehensively explored. Here, we use tooth root development in mouse as a model to investigate how sensory nerves regulate organogenesis. We show that sensory nerve fibers are enriched in the dental papilla at the initiation of tooth root development. Through single cell RNA-sequencing analysis of the trigeminal ganglion and developing molar, we reveal several signaling pathways that connect the sensory nerve with the developing molar, of which FGF signaling appears to be one of the important regulators. Fgfr2 is expressed in the progenitor cells during tooth root development. Loss of FGF signaling leads to shortened roots with compromised proliferation and differentiation of progenitor cells. Furthermore, Hh signaling is impaired in Gli1-CreER;Fgfr2fl\/fl mice. Modulation of Hh signaling rescues the tooth root defects in these mice. Collectively, our findings elucidate the nerve-progenitor crosstalk and reveal the molecular mechanism of the FGF-SHH signaling cascade during tooth root morphogenesis.<\/jats:p>","DOI":"10.1242\/dev.202043","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T11:35:47Z","timestamp":1702899347000},"source":"Crossref","is-referenced-by-count":15,"title":["Sensory nerve regulates progenitor cells via FGF-SHH axis in tooth root morphogenesis"],"prefix":"10.1242","volume":"151","author":[{"given":"Fei","family":"Pei","sequence":"first","affiliation":[{"name":"Center for Craniofacial Molecular Biology, University of Southern California 1 , 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033 , USA"},{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University 2 , Wuhan 430079 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[{"name":"Center for Craniofacial Molecular Biology, University of Southern California 1 , 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingwei","family":"Guo","sequence":"additional","affiliation":[{"name":"Center for Craniofacial Molecular Biology, University of Southern California 1 , 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Craniofacial Molecular Biology, University of Southern California 1 , 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjun","family":"Jing","sequence":"additional","affiliation":[{"name":"Center for Craniofacial Molecular Biology, University of Southern California 1 , 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Wen","sequence":"additional","affiliation":[{"name":"Center for Craniofacial Molecular Biology, University of Southern California 1 , 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jifan","family":"Feng","sequence":"additional","affiliation":[{"name":"Center for Craniofacial Molecular Biology, University of Southern California 1 , 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Lei","sequence":"additional","affiliation":[{"name":"Center for Craniofacial Molecular Biology, University of Southern California 1 , 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhi","family":"He","sequence":"additional","affiliation":[{"name":"Center for Craniofacial Molecular Biology, University of Southern California 1 , 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Jane\u010dkov\u00e1","sequence":"additional","affiliation":[{"name":"Center for Craniofacial Molecular Biology, University of Southern California 1 , 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thach-Vu","family":"Ho","sequence":"additional","affiliation":[{"name":"Center for Craniofacial Molecular Biology, University of Southern California 1 , 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Fu","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Craniofacial Molecular Biology, University of Southern California 1 , 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2477-7247","authenticated-orcid":false,"given":"Yang","family":"Chai","sequence":"additional","affiliation":[{"name":"Center for Craniofacial Molecular Biology, University of Southern California 1 , 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2024,1,11]]},"reference":[{"key":"2024011113110775500_DEV202043C1","doi-asserted-by":"publisher","first-page":"49","DOI":"10.3389\/fphys.2016.00049","article-title":"The nervous system orchestrates and integrates craniofacial development: a review","volume":"7","author":"Adameyko","year":"2016","journal-title":"Front. 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