{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:50:23Z","timestamp":1789069823346,"version":"build-2803163510"},"reference-count":80,"publisher":"The Company of Biologists","issue":"21","license":[{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100016027","name":"NYU Grossman School of Medicine","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100016027","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Reciprocal interactions between non-myocytes and cardiomyocytes regulate cardiac growth and differentiation. Here, we report that the transcription factor Ebf1 is highly expressed in non-myocytes and potently regulates heart development. Ebf1-deficient hearts display myocardial hypercellularity and reduced cardiomyocyte size, ventricular conduction system hypoplasia, and conduction system disease. Growth abnormalities in Ebf1 knockout hearts are observed as early as embryonic day 13.5. Transcriptional profiling of Ebf1-deficient embryonic cardiac non-myocytes demonstrates dysregulation of Polycomb repressive complex 2 targets, and ATAC-Seq reveals altered chromatin accessibility near many of these same genes. Gene set enrichment analysis of differentially expressed genes in cardiomyocytes isolated from E13.5 hearts of wild-type and mutant mice reveals significant enrichment of MYC targets and, consistent with this finding, we observe increased abundance of MYC in mutant hearts. EBF1-deficient non-myocytes, but not wild-type non-myocytes, are sufficient to induce excessive accumulation of MYC in co-cultured wild-type cardiomyocytes. Finally, we demonstrate that BMP signaling induces Ebf1 expression in embryonic heart cultures and controls a gene program enriched in EBF1 targets. These data reveal a previously unreported non-cell-autonomous pathway controlling cardiac growth and differentiation.<\/jats:p>","DOI":"10.1242\/dev.202054","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T10:11:49Z","timestamp":1696327909000},"source":"Crossref","is-referenced-by-count":9,"title":["The transcription factor EBF1 non-cell-autonomously regulates cardiac growth and differentiation"],"prefix":"10.1242","volume":"150","author":[{"given":"Eugene E.","family":"Kim","sequence":"first","affiliation":[{"name":"NYU Grossman School of Medicine Leon H. Charney Division of Cardiology , , New York, NY 10016 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshay","family":"Shekhar","sequence":"additional","affiliation":[{"name":"NYU Grossman School of Medicine Leon H. Charney Division of Cardiology , , New York, NY 10016 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7439-532X","authenticated-orcid":false,"given":"Jayalakshmi","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"NYU Grossman School of Medicine Leon H. Charney Division of Cardiology , , New York, NY 10016 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Khodadadi-Jamayran","sequence":"additional","affiliation":[{"name":"NYU Grossman School of Medicine Leon H. Charney Division of Cardiology , , New York, NY 10016 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"NYU Grossman School of Medicine Leon H. Charney Division of Cardiology , , New York, NY 10016 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"NYU Grossman School of Medicine Leon H. Charney Division of Cardiology , , New York, NY 10016 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2366-8527","authenticated-orcid":false,"given":"Glenn I.","family":"Fishman","sequence":"additional","affiliation":[{"name":"NYU Grossman School of Medicine Leon H. Charney Division of Cardiology , , New York, NY 10016 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2023,10,24]]},"reference":[{"key":"2023102411224887400_DEV202054C1","doi-asserted-by":"publisher","first-page":"8015","DOI":"10.1128\/MCB.22.22.8015-8025.2002","article-title":"Early B-cell factor (O\/E-1) is a promoter of adipogenesis and involved in control of genes important for terminal adipocyte differentiation","volume":"22","author":"A\u00e5kerblad","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"2023102411224887400_DEV202054C2","doi-asserted-by":"publisher","first-page":"20210325","DOI":"10.1098\/rstb.2021.0325","article-title":"Sarcomere maturation: function acquisition, molecular mechanism, and interplay with other organelles","volume":"377","author":"Ahmed","year":"2022","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"2023102411224887400_DEV202054C3","doi-asserted-by":"publisher","first-page":"5083","DOI":"10.1002\/j.1460-2075.1993.tb06202.x","article-title":"The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max","volume":"12","author":"Amati","year":"1993","journal-title":"EMBO J."},{"key":"2023102411224887400_DEV202054C4","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq--a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"2023102411224887400_DEV202054C5","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1161\/CIRCRESAHA.107.169565","article-title":"Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system","volume":"102","author":"Bakker","year":"2008","journal-title":"Circ. Res."},{"key":"2023102411224887400_DEV202054C6","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1002\/(SICI)1097-0177(200006)218:2&lt;383::AID-DVDY11&gt;3.0.CO;2-P","article-title":"Requirement for BMP and FGF signaling during cardiogenic induction in non-precardiac mesoderm is specific, transient, and cooperative","volume":"218","author":"Barron","year":"2000","journal-title":"Dev. Dyn."},{"key":"2023102411224887400_DEV202054C7","doi-asserted-by":"publisher","first-page":"15842","DOI":"10.1038\/s41598-020-72698-w","article-title":"Egr1 loss-of-function promotes beige adipocyte differentiation and activation specifically in inguinal subcutaneous white adipose tissue","volume":"10","author":"Bl\u00e9her","year":"2020","journal-title":"Sci. Rep."},{"key":"2023102411224887400_DEV202054C8","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1111\/imr.12206","article-title":"The regulatory network of B-cell differentiation: a focused view of early B-cell factor 1 function","volume":"261","author":"Boller","year":"2014","journal-title":"Immunol. Rev."},{"key":"2023102411224887400_DEV202054C9","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.immuni.2016.02.021","article-title":"Pioneering activity of the C-terminal domain of EBF1 shapes the chromatin landscape for B cell programming","volume":"44","author":"Boller","year":"2016","journal-title":"Immunity"},{"key":"2023102411224887400_DEV202054C10","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1038\/s41419-019-2003-5","article-title":"c-Myc shuttled by tumour-derived extracellular vesicles promotes lung bronchial cell proliferation through miR-19b and miR-92a","volume":"10","author":"Borzi","year":"2019","journal-title":"Cell Death Dis."},{"key":"2023102411224887400_DEV202054C11","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/1471-2369-11-31","article-title":"Bone Morphogenetic Protein (BMP)-7 expression is decreased in human hypertensive nephrosclerosis","volume":"11","author":"Bramlage","year":"2010","journal-title":"BMC Nephrol."},{"key":"2023102411224887400_DEV202054C12","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1152\/physrev.00017.2002","article-title":"Cardiac endothelial-myocardial signaling: its role in cardiac growth, contractile performance, and rhythmicity","volume":"83","author":"Brutsaert","year":"2003","journal-title":"Physiol. Rev."},{"key":"2023102411224887400_DEV202054C13","doi-asserted-by":"publisher","first-page":"21.29.1","DOI":"10.1002\/0471142727.mb2129s109","article-title":"ATAC-seq: a method for assaying chromatin accessibility genome-wide","volume":"109","author":"Buenrostro","year":"2015","journal-title":"Curr. Protoc. Mol. Biol."},{"key":"2023102411224887400_DEV202054C14","doi-asserted-by":"publisher","first-page":"5223","DOI":"10.1096\/fj.201902249RR","article-title":"Epicardial cell lineages and the origin of the coronary endothelium","volume":"34","author":"Carmona","year":"2020","journal-title":"FASEB J."},{"key":"2023102411224887400_DEV202054C15","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.1242\/dev.01094","article-title":"BMP10 is essential for maintaining cardiac growth during murine cardiogenesis","volume":"131","author":"Chen","year":"2004","journal-title":"Development"},{"key":"2023102411224887400_DEV202054C16","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.cell.2012.03.003","article-title":"MYC on the path to cancer","volume":"149","author":"Dang","year":"2012","journal-title":"Cell"},{"key":"2023102411224887400_DEV202054C17","doi-asserted-by":"publisher","first-page":"a014217","DOI":"10.1101\/cshperspect.a014217","article-title":"MYC, metabolism, cell growth, and tumorigenesis","volume":"3","author":"Dang","year":"2013","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"2023102411224887400_DEV202054C18","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/s41586-018-0110-6","article-title":"Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation","volume":"557","author":"Del Monte-Nieto","year":"2018","journal-title":"Nature"},{"key":"2023102411224887400_DEV202054C19","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1084\/jem.188.12.2215","article-title":"The transcription factor Early Growth Response 1 (Egr-1) advances differentiation of pre-B and immature B cells","volume":"188","author":"Dinkel","year":"1998","journal-title":"J. Exp. Med."},{"key":"2023102411224887400_DEV202054C20","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"2023102411224887400_DEV202054C21","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0925-4773(01)00486-5","article-title":"The COE--Collier\/Olf1\/EBF--transcription factors: structural conservation and diversity of developmental functions","volume":"108","author":"Dubois","year":"2001","journal-title":"Mech. Dev."},{"key":"2023102411224887400_DEV202054C22","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S0960-9822(98)70084-3","article-title":"XCoe2, a transcription factor of the Col\/Olf-1\/EBF family involved in the specification of primary neurons in Xenopus","volume":"8","author":"Dubois","year":"1998","journal-title":"Curr. Biol."},{"key":"2023102411224887400_DEV202054C23","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1002\/ar.a.20398","article-title":"Epicardium-derived cells are important for correct development of the Purkinje fibers in the avian heart","volume":"288","author":"Eralp","year":"2006","journal-title":"Anat. Rec. A Discov. Mol. Cell Evol. Biol."},{"key":"2023102411224887400_DEV202054C24","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3390\/jcdd8080089","article-title":"The cardiac neural crest cells in heart development and congenital heart defects","volume":"8","author":"Erhardt","year":"2021","journal-title":"J. Cardiovasc. Dev. Dis."},{"key":"2023102411224887400_DEV202054C25","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1038\/ki.2013.433","article-title":"Early B-cell factor 1 is an essential transcription factor for postnatal glomerular maturation","volume":"85","author":"Fretz","year":"2014","journal-title":"Kidney Int."},{"key":"2023102411224887400_DEV202054C26","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1002\/stem.1252","article-title":"TGF-\u03b2-superfamily signaling regulates embryonic stem cell heterogeneity: self-renewal as a dynamic and regulated equilibrium","volume":"31","author":"Galvin-Burgess","year":"2013","journal-title":"Stem Cells"},{"key":"2023102411224887400_DEV202054C27","doi-asserted-by":"publisher","first-page":"6013","DOI":"10.1242\/dev.00840","article-title":"Ebf gene function is required for coupling neuronal differentiation and cell cycle exit","volume":"130","author":"Garcia-Dominguez","year":"2003","journal-title":"Development"},{"key":"2023102411224887400_DEV202054C28","doi-asserted-by":"publisher","first-page":"5285","DOI":"10.1242\/dev.126.23.5285","article-title":"Ebf1 controls early cell differentiation in the embryonic striatum","volume":"126","author":"Garel","year":"1999","journal-title":"Development"},{"key":"2023102411224887400_DEV202054C29","doi-asserted-by":"publisher","first-page":"5621","DOI":"10.1242\/dev.00166","article-title":"The early topography of thalamocortical projections is shifted in Ebf1 and Dlx1\/2 mutant mice","volume":"129","author":"Garel","year":"2002","journal-title":"Development"},{"key":"2023102411224887400_DEV202054C30","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1161\/CIRCRESAHA.118.314578","article-title":"Transcriptomic profiling of the developing cardiac conduction system at single-cell resolution","volume":"125","author":"Goodyer","year":"2019","journal-title":"Circ. Res."},{"key":"2023102411224887400_DEV202054C31","doi-asserted-by":"publisher","first-page":"H1091","DOI":"10.1152\/ajpheart.00100.2003","article-title":"Subdiaphragmatic murine electrophysiological studies: sequential determination of ventricular refractoriness and arrhythmia induction","volume":"285","author":"Gutstein","year":"2003","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2023102411224887400_DEV202054C32","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1101\/gad.7.5.760","article-title":"Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression","volume":"7","author":"Hagman","year":"1993","journal-title":"Genes Dev."},{"key":"2023102411224887400_DEV202054C33","doi-asserted-by":"publisher","first-page":"4013","DOI":"10.1128\/MCB.23.11.4013-4025.2003","article-title":"Evolutionary divergence of platelet-derived growth factor alpha receptor signaling mechanisms","volume":"23","author":"Hamilton","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"2023102411224887400_DEV202054C34","doi-asserted-by":"publisher","first-page":"21469","DOI":"10.1073\/pnas.2009119117","article-title":"A specialized population of Periostin-expressing cardiac fibroblasts contributes to postnatal cardiomyocyte maturation and innervation","volume":"117","author":"Hortells","year":"2020","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2023102411224887400_DEV202054C35","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1146\/annurev.physiol.68.040104.124629","article-title":"Endothelial-cardiomyocyte interactions in cardiac development and repair","volume":"68","author":"Hsieh","year":"2006","journal-title":"Annu. Rev. Physiol."},{"key":"2023102411224887400_DEV202054C36","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1128\/MCB.01557-06","article-title":"Critical role for Ebf1 and Ebf2 in the adipogenic transcriptional cascade","volume":"27","author":"Jimenez","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"2023102411224887400_DEV202054C37","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1021\/acs.biochem.5b01191","article-title":"PRC2 and SWI\/SNF chromatin remodeling complexes in health and disease","volume":"55","author":"Kadoch","year":"2016","journal-title":"Biochemistry"},{"key":"2023102411224887400_DEV202054C38","doi-asserted-by":"publisher","first-page":"W212","DOI":"10.1093\/nar\/gkz446","article-title":"ChEA3: transcription factor enrichment analysis by orthogonal omics integration","volume":"47","author":"Keenan","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2023102411224887400_DEV202054C39","doi-asserted-by":"publisher","first-page":"5027","DOI":"10.1172\/JCI77495","article-title":"PCP4 regulates Purkinje cell excitability and cardiac rhythmicity","volume":"124","author":"Kim","year":"2014","journal-title":"J. Clin. Invest."},{"key":"2023102411224887400_DEV202054C40","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/1475-2867-14-65","article-title":"The effect of epiregulin on epidermal growth factor receptor expression and proliferation of oral squamous cell carcinoma cell lines","volume":"14","author":"Kong","year":"2014","journal-title":"Cancer Cell Int."},{"key":"2023102411224887400_DEV202054C41","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/378394a0","article-title":"Requirement for neuregulin receptor erbB2 in neural and cardiac development","volume":"378","author":"Lee","year":"1995","journal-title":"Nature"},{"key":"2023102411224887400_DEV202054C42","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1101\/gr.234633.118","article-title":"Human cardiac cis-regulatory elements, their cognate transcription factors, and regulatory DNA sequence variants","volume":"28","author":"Lee","year":"2018","journal-title":"Genome Res."},{"key":"2023102411224887400_DEV202054C43","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1038\/387422a0","article-title":"Myc and Ras collaborate in inducing accumulation of active cyclin E\/Cdk2 and E2F","volume":"387","author":"Leone","year":"1997","journal-title":"Nature"},{"key":"2023102411224887400_DEV202054C44","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/376263a0","article-title":"Failure of B-cell differentiation in mice lacking the transcription factor EBF","volume":"376","author":"Lin","year":"1995","journal-title":"Nature"},{"key":"2023102411224887400_DEV202054C45","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"2023102411224887400_DEV202054C46","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"2023102411224887400_DEV202054C47","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1002\/stem.1921","article-title":"Isolation and characterization of embryonic stem cell-derived cardiac Purkinje cells","volume":"33","author":"Maass","year":"2015","journal-title":"Stem Cells"},{"key":"2023102411224887400_DEV202054C48","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s13287-019-1187-z","article-title":"Impact of c-MYC expression on proliferation, differentiation, and risk of neoplastic transformation of human mesenchymal stromal cells","volume":"10","author":"Melnik","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"2023102411224887400_DEV202054C49","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.stem.2020.10.003","article-title":"BMP10 signaling promotes the development of endocardial cells from human pluripotent stem cell-derived cardiovascular progenitors","volume":"28","author":"Mikryukov","year":"2021","journal-title":"Cell Stem Cell"},{"key":"2023102411224887400_DEV202054C50","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1242\/dev.02279","article-title":"Notch1b and neuregulin are required for specification of central cardiac conduction tissue","volume":"133","author":"Milan","year":"2006","journal-title":"Development"},{"key":"2023102411224887400_DEV202054C51","doi-asserted-by":"publisher","first-page":"13714","DOI":"10.1074\/jbc.M117.778506","article-title":"Bone morphogenetic protein 9 (BMP9) and BMP10 enhance tumor necrosis factor-\u03b1-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2","volume":"292","author":"Mitrofan","year":"2017","journal-title":"J. Biol. Chem."},{"key":"2023102411224887400_DEV202054C52","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1007\/s00246-018-1906-8","article-title":"Developmental origin of the cardiac conduction system: insight from lineage tracing","volume":"39","author":"Mohan","year":"2018","journal-title":"Pediatr. Cardiol."},{"key":"2023102411224887400_DEV202054C53","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1016\/j.cell.2007.04.036","article-title":"A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development","volume":"129","author":"Moskowitz","year":"2007","journal-title":"Cell"},{"key":"2023102411224887400_DEV202054C54","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1038\/ni.2641","article-title":"Transcription factor EBF1 is essential for the maintenance of B cell identity and prevention of alternative fates in committed cells","volume":"14","author":"Nechanitzky","year":"2013","journal-title":"Nat. Immunol."},{"key":"2023102411224887400_DEV202054C55","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1681\/ASN.2018070699","article-title":"Early B Cell Factor 1 (EBF1) regulates glomerular development by controlling mesangial maturation and consequently COX-2 expression","volume":"30","author":"Nelson","year":"2019","journal-title":"J. Am. Soc. Nephrol."},{"key":"2023102411224887400_DEV202054C56","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1530\/REP-14-0005","article-title":"Roles of Gremlin 1 and Gremlin 2 in regulating ovarian primordial to primary follicle transition","volume":"147","author":"Nilsson","year":"2014","journal-title":"Reproduction"},{"key":"2023102411224887400_DEV202054C57","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41389-019-0137-z","article-title":"TBX3 represses TBX2 under the control of the PRC2 complex in skeletal muscle and rhabdomyosarcoma","volume":"8","author":"Oh","year":"2019","journal-title":"Oncogenesis"},{"key":"2023102411224887400_DEV202054C58","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s00418-021-02015-7","article-title":"EBF1 is expressed in pericytes and contributes to pericyte cell commitment","volume":"156","author":"Pagani","year":"2021","journal-title":"Histochem. Cell Biol."},{"key":"2023102411224887400_DEV202054C59","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1161\/CIRCEP.109.928820","article-title":"Contactin-2 expression in the cardiac Purkinje fiber network","volume":"3","author":"Pallante","year":"2010","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"2023102411224887400_DEV202054C60","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1242\/bio.20135785","article-title":"Pocket proteins critically regulate cell cycle exit of the trabecular myocardium and the ventricular conduction system","volume":"2","author":"Park","year":"2013","journal-title":"Biol. Open"},{"key":"2023102411224887400_DEV202054C61","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1186\/1471-2369-14-227","article-title":"Angiopoietin-1 treated early endothelial outgrowth cells (eEOCs) are activated in vitro and reduce renal damage in murine acute ischemic kidney injury (iAKI)","volume":"14","author":"Patschan","year":"2013","journal-title":"BMC Nephrol."},{"key":"2023102411224887400_DEV202054C62","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.yexcr.2008.08.015","article-title":"The role of Neuregulin-1beta\/ErbB signaling in the heart","volume":"315","author":"Pentassuglia","year":"2009","journal-title":"Exp. Cell Res."},{"key":"2023102411224887400_DEV202054C63","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/j.cell.2007.01.042","article-title":"An Nkx2-5\/Bmp2\/Smad1 negative feedback loop controls heart progenitor specification and proliferation","volume":"128","author":"Prall","year":"2007","journal-title":"Cell"},{"key":"2023102411224887400_DEV202054C64","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1161\/CIRCRESAHA.119.315857","article-title":"The role of the epicardium during heart development and repair","volume":"126","author":"Quijada","year":"2020","journal-title":"Circ. Res."},{"key":"2023102411224887400_DEV202054C65","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"2023102411224887400_DEV202054C66","doi-asserted-by":"publisher","first-page":"10464","DOI":"10.1073\/pnas.162301699","article-title":"Neuregulin-1 promotes formation of the murine cardiac conduction system","volume":"99","author":"Rentschler","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023102411224887400_DEV202054C67","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1172\/JCI44470","article-title":"Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways","volume":"121","author":"Rentschler","year":"2011","journal-title":"J. Clin. Invest."},{"key":"2023102411224887400_DEV202054C68","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1161\/CIRCULATIONAHA.112.103390","article-title":"Myocardial Notch signaling reprograms cardiomyocytes to a conduction-like phenotype","volume":"126","author":"Rentschler","year":"2012","journal-title":"Circulation"},{"key":"2023102411224887400_DEV202054C69","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1080\/15384101.2015.1120925","article-title":"Coordinating cell proliferation and differentiation: antagonism between cell cycle regulators and cell type-specific gene expression","volume":"15","author":"Ruijtenberg","year":"2016","journal-title":"Cell Cycle"},{"key":"2023102411224887400_DEV202054C70","doi-asserted-by":"publisher","first-page":"dev172619","DOI":"10.1242\/dev.172619","article-title":"Myocardial differentiation is dependent upon endocardial signaling during early cardiogenesis in vitro","volume":"146","author":"Saint-Jean","year":"2019","journal-title":"Development"},{"key":"2023102411224887400_DEV202054C71","doi-asserted-by":"publisher","first-page":"4614","DOI":"10.1182\/blood-2008-07-170464","article-title":"The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor","volume":"113","author":"Sprynski","year":"2009","journal-title":"Blood"},{"key":"2023102411224887400_DEV202054C72","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1158\/2159-8290.CD-15-0507","article-title":"MYC, metabolism, and cancer","volume":"5","author":"Stine","year":"2015","journal-title":"Cancer Discov."},{"key":"2023102411224887400_DEV202054C73","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.immuni.2010.04.013","article-title":"Early B cell factor 1 regulates B cell gene networks by activation, repression, and transcription- independent poising of chromatin","volume":"32","author":"Treiber","year":"2010","journal-title":"Immunity"},{"key":"2023102411224887400_DEV202054C80","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1084\/jem.20132100","article-title":"Combined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B cell progenitors","volume":"212","author":"Ungerb\u00e4ck","year":"2015","journal-title":"J. Exp. Med."},{"key":"2023102411224887400_DEV202054C74","doi-asserted-by":"publisher","first-page":"7062","DOI":"10.1073\/pnas.1220558110","article-title":"Zif268\/egr1 gene controls the selection, maturation and functional integration of adult hippocampal newborn neurons by learning","volume":"110","author":"Veyrac","year":"2013","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2023102411224887400_DEV202054C75","doi-asserted-by":"publisher","first-page":"2585","DOI":"10.1038\/s41467-020-16204-w","article-title":"Single-cell analysis of murine fibroblasts identifies neonatal to adult switching that regulates cardiomyocyte maturation","volume":"11","author":"Wang","year":"2020","journal-title":"Nat. Commun."},{"key":"2023102411224887400_DEV202054C76","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/j.immuni.2020.10.009","article-title":"A prion-like domain in transcription factor EBF1 promotes phase separation and enables B cell programming of progenitor chromatin","volume":"53","author":"Wang","year":"2020","journal-title":"Immunity"},{"key":"2023102411224887400_DEV202054C77","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/j.cell.2012.10.023","article-title":"Endocardial cells form the coronary arteries by angiogenesis through myocardial-endocardial VEGF signaling","volume":"151","author":"Wu","year":"2012","journal-title":"Cell"},{"key":"2023102411224887400_DEV202054C78","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.febslet.2013.01.049","article-title":"The transcription factor early B-cell factor 1 regulates bone formation in an osteoblast-nonautonomous manner","volume":"587","author":"Zee","year":"2013","journal-title":"FEBS Lett."},{"key":"2023102411224887400_DEV202054C79","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1161\/CIRCRESAHA.117.312136","article-title":"Endocardial cell plasticity in cardiac development, diseases and regeneration","volume":"122","author":"Zhang","year":"2018","journal-title":"Circ. Res."}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.202054\/3199618\/dev202054.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.202054\/3239964\/dev202054.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.202054\/3239964\/dev202054.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T11:23:54Z","timestamp":1698146634000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/150\/21\/dev202054\/334151\/The-transcription-factor-EBF1-non-cell"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,24]]},"references-count":80,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2023,11,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.202054","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,24]]},"article-number":"dev202054"}}