{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:48:03Z","timestamp":1788889683912,"version":"build-2803163510"},"reference-count":184,"publisher":"The Company of Biologists","issue":"19","funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"crossref","award":["NIH R35 DE027550"],"award-info":[{"award-number":["NIH R35 DE027550"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The evolution of a unique craniofacial complex in vertebrates made possible new ways of breathing, eating, communicating and sensing the environment. The head and face develop through interactions of all three germ layers, the endoderm, ectoderm and mesoderm, as well as the so-called fourth germ layer, the cranial neural crest. Over a century of experimental embryology and genetics have revealed an incredible diversity of cell types derived from each germ layer, signaling pathways and genes that coordinate craniofacial development, and how changes to these underlie human disease and vertebrate evolution. Yet for many diseases and congenital anomalies, we have an incomplete picture of the causative genomic changes, in particular how alterations to the non-coding genome might affect craniofacial gene expression. Emerging genomics and single-cell technologies provide an opportunity to obtain a more holistic view of the genes and gene regulatory elements orchestrating craniofacial development across vertebrates. These single-cell studies generate novel hypotheses that can be experimentally validated in vivo. In this Review, we highlight recent advances in single-cell studies of diverse craniofacial structures, as well as potential pitfalls and the need for extensive in vivo validation. We discuss how these studies inform the developmental sources and regulation of head structures, bringing new insights into the etiology of structural birth anomalies that affect the vertebrate head.<\/jats:p>","DOI":"10.1242\/dev.202077","type":"journal-article","created":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T12:46:00Z","timestamp":1696855560000},"source":"Crossref","is-referenced-by-count":14,"title":["Craniofacial developmental biology in the single-cell era"],"prefix":"10.1242","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4870-7801","authenticated-orcid":false,"given":"Kuo-Chang","family":"Tseng","sequence":"first","affiliation":[{"name":"Keck School of Medicine of University of Southern California Department of Stem Cell Biology and Regenerative Medicine , , Los Angeles, CA 90033 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3209-0026","authenticated-orcid":false,"given":"J. Gage","family":"Crump","sequence":"additional","affiliation":[{"name":"Keck School of Medicine of University of Southern California Department of Stem Cell Biology and Regenerative Medicine , , Los Angeles, CA 90033 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2023,10,9]]},"reference":[{"key":"2023100912444750000_DEV202077C1","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1038\/nmeth.4463","article-title":"SCENIC: single-cell regulatory network inference and clustering","volume":"14","author":"Aibar","year":"2017","journal-title":"Nat. Methods"},{"key":"2023100912444750000_DEV202077C2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2023.07.013","article-title":"Single-cell census of human tooth development enables generation of human enamel","author":"Alghadeer","year":"2023","journal-title":"Dev. 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