{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T01:40:36Z","timestamp":1780623636038,"version":"3.54.1"},"reference-count":136,"publisher":"The Company of Biologists","issue":"3","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 AG02656106A1"],"award-info":[{"award-number":["R01 AG02656106A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["5T32GM007067-44"],"award-info":[{"award-number":["5T32GM007067-44"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["P60-DK-20579"],"award-info":[{"award-number":["P60-DK-20579"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["GM103422"],"award-info":[{"award-number":["GM103422"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 AG057748"],"award-info":[{"award-number":["R01 AG057748"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R21 AG058037"],"award-info":[{"award-number":["R21 AG058037"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R56 AG072169"],"award-info":[{"award-number":["R56 AG072169"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100011912","name":"Washington University School of Medicine in St. Louis","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100011912","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The renin-angiotensin-aldosterone system (RAAS) plays a well-characterized role regulating blood pressure in mammals. Pharmacological and genetic manipulation of the RAAS has been shown to extend lifespan in Caenorhabditis elegans, Drosophila and rodents, but its mechanism is not well defined. Here, we investigate the angiotensin-converting enzyme (ACE) inhibitor drug captopril, which extends lifespan in worms and mice. To investigate the mechanism, we performed a forward genetic screen for captopril-hypersensitive mutants. We identified a missense mutation that causes a partial loss of function of the daf-2 receptor tyrosine kinase gene, a powerful regulator of aging. The homologous mutation in the human insulin receptor causes Donohue syndrome, establishing these mutant worms as an invertebrate model of this disease. Captopril functions in C. elegans by inhibiting ACN-1, the worm homolog of ACE. Reducing the activity of acn-1 via captopril or RNA interference promoted dauer larvae formation, suggesting that acn-1 is a daf gene. Captopril-mediated lifespan extension was abrogated by daf-16(lf) and daf-12(lf) mutations. Our results indicate that captopril and acn-1 influence lifespan by modulating dauer formation pathways. We speculate that this represents a conserved mechanism of lifespan control.<\/jats:p>","DOI":"10.1242\/dev.202146","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T07:59:15Z","timestamp":1706515155000},"source":"Crossref","is-referenced-by-count":19,"title":["The ACE inhibitor captopril inhibits ACN-1 to control dauer formation and aging"],"prefix":"10.1242","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3770-5605","authenticated-orcid":false,"given":"Brian M.","family":"Egan","sequence":"first","affiliation":[{"name":"Washington University School of Medicine 1 Department of Developmental Biology , , St. Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9979-1268","authenticated-orcid":false,"given":"Franziska","family":"Pohl","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine 1 Department of Developmental Biology , , St. Louis, MO 63110, USA"},{"name":"Washington University School of Medicine 2 Department of Medicine , , St. Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2955-8476","authenticated-orcid":false,"given":"Xavier","family":"Anderson","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine 1 Department of Developmental Biology , , St. Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5669-6340","authenticated-orcid":false,"given":"Shoshana C.","family":"Williams","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine 1 Department of Developmental Biology , , St. Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imienreluefe","family":"Gregory Adodo","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine 1 Department of Developmental Biology , , St. Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Hunt","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine 1 Department of Developmental Biology , , St. Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1513-3511","authenticated-orcid":false,"given":"Zuoxu","family":"Wang","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine 1 Department of Developmental Biology , , St. Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3524-792X","authenticated-orcid":false,"given":"Chen-Hao","family":"Chiu","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine 1 Department of Developmental Biology , , St. Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7787-445X","authenticated-orcid":false,"given":"Andrea","family":"Scharf","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine 1 Department of Developmental Biology , , St. Louis, MO 63110, USA"},{"name":"Missouri University of Science and Technology 3 Department of Biological Sciences , , Rolla, MO 65409, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2181-923X","authenticated-orcid":false,"given":"Matthew","family":"Mosley","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine 1 Department of Developmental Biology , , St. Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Kumar","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine 1 Department of Developmental Biology , , St. Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9408-8901","authenticated-orcid":false,"given":"Daniel L.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine 1 Department of Developmental Biology , , St. Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideji","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine 4 Division of Endocrinology, Metabolism & Lipid Research , , St. Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5368-0183","authenticated-orcid":false,"given":"Fong-Fu","family":"Hsu","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine 4 Division of Endocrinology, Metabolism & Lipid Research , , St. Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6042-5241","authenticated-orcid":false,"given":"Kerry","family":"Kornfeld","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine 1 Department of Developmental Biology , , St. Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2024,2,12]]},"reference":[{"key":"2024021212583144400_DEV202146C1","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1093\/genetics\/165.1.127","article-title":"Isolation and characterization of high-temperature-induced dauer formation mutants in Caenorhabditis elegans","volume":"165","author":"Ailion","year":"2003","journal-title":"Genetics"},{"key":"2024021212583144400_DEV202146C2","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1242\/dev.125.7.1191","article-title":"daf-12 regulates developmental age and the dauer alternative in Caenorhabditis elegans","volume":"125","author":"Antebi","year":"1998","journal-title":"Development"},{"key":"2024021212583144400_DEV202146C3","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1101\/gad.14.12.1512","article-title":"daf-12 encodes a nuclear receptor that regulates the Dauer diapause and developmental age in C. elegans","volume":"14","author":"Antebi","year":"2000","journal-title":"Genes Dev."},{"key":"2024021212583144400_DEV202146C4","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1534\/genetics.114.169730","article-title":"Efficient marker-free recovery of custom genetic modifications with CRISPR\/Cas9 in Caenorhabditis elegans","volume":"198","author":"Arribere","year":"2014","journal-title":"Genetics"},{"key":"2024021212583144400_DEV202146C5","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1016\/S0731-7085(96)01915-2","article-title":"Determination of captopril in human serum by high performance liquid chromatography using solid-phase extraction","volume":"15","author":"Bahmaei","year":"1997","journal-title":"J. Pharm. Biomed. Anal."},{"key":"2024021212583144400_DEV202146C6","doi-asserted-by":"publisher","first-page":"3338","DOI":"10.4161\/cc.7.21.7012","article-title":"Insulin and aging","volume":"7","author":"Bartke","year":"2008","journal-title":"Cell Cycle"},{"key":"2024021212583144400_DEV202146C7","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1161\/hy1201.101214","article-title":"History about the discovery of the renin-angiotensin system","volume":"38","author":"Basso","year":"2001","journal-title":"Hypertension"},{"key":"2024021212583144400_DEV202146C8","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.regpep.2004.12.027","article-title":"Protective effect of the inhibition of the renin\u2013angiotensin system on aging","volume":"128","author":"Basso","year":"2005","journal-title":"Regul. Pept."},{"key":"2024021212583144400_DEV202146C9","doi-asserted-by":"publisher","first-page":"H1351","DOI":"10.1152\/ajpheart.00393.2007","article-title":"Protective effect of long-term angiotensin II inhibition","volume":"293","author":"Basso","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2024021212583144400_DEV202146C10","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1172\/JCI36703","article-title":"Disruption of the Ang II type 1 receptor promotes longevity in mice","volume":"119","author":"Benigni","year":"2009","journal-title":"J. Clin. Investig."},{"key":"2024021212583144400_DEV202146C11","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/emmm.201000080","article-title":"Angiotensin II revisited: new roles in inflammation, immunology and aging","volume":"2","author":"Benigni","year":"2010","journal-title":"EMBO Mol. Med."},{"key":"2024021212583144400_DEV202146C12","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1007\/s11357-012-9408-8","article-title":"Variations of the angiotensin II type 1 receptor gene are associated with extreme human longevity","volume":"35","author":"Benigni","year":"2013","journal-title":"Age"},{"key":"2024021212583144400_DEV202146C13","doi-asserted-by":"publisher","first-page":"3299","DOI":"10.1210\/jc.2002-021810","article-title":"Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control","volume":"88","author":"Bonaf\u00e8","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2024021212583144400_DEV202146C14","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"2024021212583144400_DEV202146C15","doi-asserted-by":"publisher","first-page":"52340","DOI":"10.1074\/jbc.M308858200","article-title":"An essential role in molting and morphogenesis of Caenorhabditis elegans for ACN-1, a novel member of the angiotensin-converting enzyme family that lacks a metallopeptidase active site","volume":"278","author":"Brooks","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2024021212583144400_DEV202146C16","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1534\/g3.116.037184","article-title":"Caenorhabditis elegans DAF-2 as a model for human insulin receptoropathies","volume":"7","author":"Bulger","year":"2017","journal-title":"G3"},{"key":"2024021212583144400_DEV202146C17","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1017\/CBO9780511546198.004","article-title":"Evolution of cardiovascular systems and their endothelial linings","volume-title":"Endothelial Biomedicine","author":"Burggren","year":"2007"},{"key":"2024021212583144400_DEV202146C18","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1038\/nchembio.380","article-title":"A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans","volume":"6","author":"Burns","year":"2010","journal-title":"Nat. Chem. Biol."},{"key":"2024021212583144400_DEV202146C19","doi-asserted-by":"publisher","first-page":"B416","DOI":"10.1093\/gerona\/59.5.B416","article-title":"Angiotensin-converting enzyme inhibition, body composition, and physical performance in aged rats","volume":"59","author":"Carter","year":"2004","journal-title":"J. Gerontol. Ser. A"},{"key":"2024021212583144400_DEV202146C20","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s11357-010-9196-y","article-title":"Differential effects of enalapril and losartan on body composition and indices of muscle quality in aged male Fischer 344\u00d7Brown Norway rats","volume":"33","author":"Carter","year":"2011","journal-title":"Age"},{"key":"2024021212583144400_DEV202146C21","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/0012-1606(75)90109-8","article-title":"The dauerlarva, a post-embryonic developmental variant of the nematode Caenorhabditis elegans","volume":"46","author":"Cassada","year":"1975","journal-title":"Dev. Biol."},{"key":"2024021212583144400_DEV202146C22","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s00424-009-0725-4","article-title":"Angiotensin receptors as determinants of life span","volume":"459","author":"Cassis","year":"2010","journal-title":"Pflugers Arch. Eur. J. Physiol."},{"key":"2024021212583144400_DEV202146C23","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1534\/genetics.115.177998","article-title":"Longevity genes revealed by integrative analysis of isoform-specific daf-16\/FoxO mutants of Caenorhabditis elegans","volume":"201","author":"Chen","year":"2015","journal-title":"Genetics"},{"key":"2024021212583144400_DEV202146C24","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1126\/science.1057991","article-title":"Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein","volume":"292","author":"Clancy","year":"2001","journal-title":"Science"},{"key":"2024021212583144400_DEV202146C25","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1016\/j.exger.2006.06.038","article-title":"Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans","volume":"41","author":"Collins","year":"2006","journal-title":"Exp. Gerontol."},{"key":"2024021212583144400_DEV202146C26","doi-asserted-by":"publisher","first-page":"e1000230","DOI":"10.1371\/journal.pgen.1000230","article-title":"The anticonvulsant ethosuximide disrupts sensory function to extend C. elegans lifespan","volume":"4","author":"Collins","year":"2008","journal-title":"PLoS Genet."},{"key":"2024021212583144400_DEV202146C27","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1161\/01.HYP.17.4.589","article-title":"History of the design of captopril and related inhibitors of angiotensin converting enzyme","volume":"17","author":"Cushman","year":"1991","journal-title":"Hypertension"},{"key":"2024021212583144400_DEV202146C28","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1096\/fj.02-0063fje","article-title":"Enalapril and losartan attenuate mitochondrial dysfunction in aged rats","volume":"17","author":"de Cavanagh","year":"2003","journal-title":"FASEB J."},{"key":"2024021212583144400_DEV202146C29","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/j.exger.2008.08.007","article-title":"Renin-angiotensin system inhibitors protect against age-related changes in rat liver mitochondrial DNA content and gene expression","volume":"43","author":"de Cavanagh","year":"2008","journal-title":"Exp. Gerontol."},{"key":"2024021212583144400_DEV202146C30","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1093\/cvr\/cvq285","article-title":"Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria?","volume":"89","author":"de Cavanagh","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"2024021212583144400_DEV202146C31","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/S0022-3476(48)80231-3","article-title":"Dysendocrinism","volume":"32","author":"Donohue","year":"1948","journal-title":"J. Pediatr."},{"key":"2024021212583144400_DEV202146C32","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1093\/genetics\/141.4.1399","article-title":"The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans","volume":"141","author":"Dorman","year":"1995","journal-title":"Genetics"},{"key":"2024021212583144400_DEV202146C33","doi-asserted-by":"publisher","first-page":"3351","DOI":"10.3390\/ijms19113351","article-title":"Age-and genotype-specific effects of the angiotensin-converting enzyme inhibitor lisinopril on mitochondrial and metabolic parameters in Drosophila melanogaster","volume":"19","author":"Ederer","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"2024021212583144400_DEV202146C34","doi-asserted-by":"publisher","first-page":"938650","DOI":"10.3389\/fphar.2022.938650","article-title":"Control of aging by the renin\u2013angiotensin system: a review of C. elegans, Drosophila, and mammals","volume":"13","author":"Egan","year":"2022","journal-title":"Front. Pharmacol."},{"key":"2024021212583144400_DEV202146C35","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1126\/science.1105299","article-title":"Anticonvulsant medications extend worm life-span","volume":"307","author":"Evason","year":"2005","journal-title":"Science"},{"key":"2024021212583144400_DEV202146C36","doi-asserted-by":"publisher","first-page":"C15","DOI":"10.1152\/ajpcell.1993.265.1.C15","article-title":"Effects of angiotensin-converting enzyme inhibition on mitochondrial number in the aging mouse","volume":"265","author":"Ferder","year":"1993","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"2024021212583144400_DEV202146C37","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1681\/ASN.V541147","article-title":"Decreased glomeruloscierosis in aging by angiotensin-converting enzyme inhibitor","volume":"5","author":"Ferder","year":"1994","journal-title":"J. Am. Soc. Nephrol."},{"key":"2024021212583144400_DEV202146C38","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S1471-4892(02)00139-X","article-title":"Advances in our understanding of aging: role of the renin\u2013angiotensin system","volume":"2","author":"Ferder","year":"2002","journal-title":"Curr. Opin. Pharmacol."},{"key":"2024021212583144400_DEV202146C39","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/j.1474-9726.2006.00203.x","article-title":"The nuclear hormone receptor DAF-12 has opposing effects on Caenorhabditis elegans lifespan and regulates genes repressed in multiple long-lived worms","volume":"5","author":"Fisher","year":"2006","journal-title":"Aging Cell"},{"key":"2024021212583144400_DEV202146C40","doi-asserted-by":"publisher","first-page":"e312","DOI":"10.1371\/journal.pbio.0030312","article-title":"Functional genomic analysis of C. elegans molting","volume":"3","author":"Frand","year":"2005","journal-title":"PLoS Biol."},{"key":"2024021212583144400_DEV202146C41","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1093\/genetics\/118.1.75","article-title":"A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility","volume":"118","author":"Friedman","year":"1988","journal-title":"Genetics"},{"key":"2024021212583144400_DEV202146C42","doi-asserted-by":"publisher","first-page":"B102","DOI":"10.1093\/geronj\/43.4.B102","article-title":"Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene","volume":"43","author":"Friedman","year":"1988","journal-title":"J. Gerontol."},{"key":"2024021212583144400_DEV202146C43","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1111\/j.1365-2796.2008.01981.x","article-title":"Renin-angiotensin system revisited","volume":"264","author":"Fyhrquist","year":"2008","journal-title":"J. Intern. Med."},{"key":"2024021212583144400_DEV202146C44","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1093\/gerona\/glz152","article-title":"Lisinopril preserves physical resilience and extends life span in a genotype-specific manner in Drosophila melanogaster","volume":"74","author":"Gabrawy","year":"2019","journal-title":"J. Gerontol. A"},{"key":"2024021212583144400_DEV202146C45","doi-asserted-by":"publisher","first-page":"143","DOI":"10.3390\/genes13010143","article-title":"Genome-wide analysis in Drosophila reveals the genetic basis of variation in age-specific physical performance and response to ACE inhibition","volume":"13","author":"Gabrawy","year":"2022","journal-title":"Genes"},{"key":"2024021212583144400_DEV202146C46","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/j.arr.2013.04.001","article-title":"The ACE DD genotype and D-allele are associated with exceptional longevity: a meta-analysis","volume":"12","author":"Garatachea","year":"2013","journal-title":"Ageing Res. Rev."},{"key":"2024021212583144400_DEV202146C47","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1093\/genetics\/150.1.129","article-title":"Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans","volume":"150","author":"Gems","year":"1998","journal-title":"Genetics"},{"key":"2024021212583144400_DEV202146C48","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/0012-1606(84)90201-X","article-title":"The Caenorhabditis elegans dauer larva: developmental effects of pheromone, food, and temperature","volume":"102","author":"Golden","year":"1984","journal-title":"Dev. Biol."},{"key":"2024021212583144400_DEV202146C49","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/S0895-7061(00)01209-7","article-title":"Effect of chronic angiotensin II inhibition on the cardiovascular system of the normal rat","volume":"13","author":"Gonz\u00e1lez Bosc","year":"2000","journal-title":"Am. J. Hypertens."},{"key":"2024021212583144400_DEV202146C50","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1093\/genetics\/137.1.107","article-title":"daf-2, daf-16 and daf-23: genetically interacting genes controlling dauer formation in Caenorhabditis elegans","volume":"137","author":"Gottlieb","year":"1994","journal-title":"Genetics"},{"key":"2024021212583144400_DEV202146C51","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.molcel.2013.12.013","article-title":"Extensive oscillatory gene expression during C. elegans larval development","volume":"53","author":"Hendriks","year":"2014","journal-title":"Mol. Cell"},{"key":"2024021212583144400_DEV202146C52","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1096\/fasebj.13.11.1385","article-title":"The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans","volume":"13","author":"Honda","year":"1999","journal-title":"FASEB J."},{"key":"2024021212583144400_DEV202146C53","first-page":"1","article-title":"Dauer","volume-title":"WormBook: The Online Review of C. elegans Biology","author":"Hu","year":"2018"},{"key":"2024021212583144400_DEV202146C54","doi-asserted-by":"publisher","first-page":"8084","DOI":"10.1073\/pnas.0400848101","article-title":"Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans","volume":"101","author":"Huang","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024021212583144400_DEV202146C55","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/j.jpba.2005.12.007","article-title":"Simultaneous determination of captopril and hydrochlorothiazide in human plasma by reverse-phase HPLC from linear gradient elution","volume":"41","author":"Huang","year":"2006","journal-title":"J. Pharm. Biomed. Anal."},{"key":"2024021212583144400_DEV202146C56","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1534\/genetics.111.130450","article-title":"Identification of mutations that delay somatic or reproductive aging of Caenorhabditis elegans","volume":"189","author":"Hughes","year":"2011","journal-title":"Genetics"},{"key":"2024021212583144400_DEV202146C57","doi-asserted-by":"publisher","first-page":"8","DOI":"10.5457\/ams.v38i1.33","article-title":"A short history of the renin-angiotensin system","volume":"38","author":"Igic","year":"2009","journal-title":"Acta Med. Salin."},{"key":"2024021212583144400_DEV202146C58","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S0531-5565(02)00264-4","article-title":"Effects of renin\u2013angiotensin system blockade in the aging kidney","volume":"38","author":"Inserra","year":"2003","journal-title":"Exp. Gerontol."},{"key":"2024021212583144400_DEV202146C59","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1161\/01.HYP.25.3.437","article-title":"Cardiovascular changes by long-term inhibition of the renin-angiotensin system in aging","volume":"25","author":"Inserra","year":"1995","journal-title":"Hypertension"},{"key":"2024021212583144400_DEV202146C60","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1177\/1753944709339195","article-title":"Changes seen in the aging kidney and the effect of blocking the renin\u2013angiotensin system","volume":"3","author":"Inserra","year":"2009","journal-title":"Ther. Adv. Cardiovasc. Dis."},{"key":"2024021212583144400_DEV202146C61","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/S0531-5565(00)00138-8","article-title":"Gerontogenes mediate health and longevity in nematodes through increasing resistance to environmental toxins and stressors","volume":"35","author":"Johnson","year":"2000","journal-title":"Exp. Gerontol."},{"key":"2024021212583144400_DEV202146C62","doi-asserted-by":"publisher","first-page":"research0002","DOI":"10.1186\/gb-2000-2-1-research0002","article-title":"Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans","volume":"2","author":"Kamath","year":"2000","journal-title":"Genome Biol."},{"key":"2024021212583144400_DEV202146C63","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nature01278","article-title":"Systematic functional analysis of the Caenorhabditis elegans genome using RNAi","volume":"421","author":"Kamath","year":"2003","journal-title":"Nature"},{"key":"2024021212583144400_DEV202146C64","doi-asserted-by":"publisher","first-page":"288","DOI":"10.3389\/fphys.2013.00288","article-title":"Functional implications of Drosophila insulin-like peptides in metabolism, aging, and dietary restriction","volume":"4","author":"Kannan","year":"2013","journal-title":"Front. Physiol."},{"key":"2024021212583144400_DEV202146C65","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J. Am. Stat. Assoc."},{"key":"2024021212583144400_DEV202146C66","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1093\/gerona\/gly219","article-title":"Chronic treatment with the ace inhibitor enalapril attenuates the development of frailty and differentially modifies pro- and anti-inflammatory cytokines in aging male and female c57bl\/6 mice","volume":"74","author":"Keller","year":"2019","journal-title":"J. Gerontol. Ser. A"},{"key":"2024021212583144400_DEV202146C67","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/nature08980","article-title":"The genetics of ageing","volume":"464","author":"Kenyon","year":"2010","journal-title":"Nature"},{"key":"2024021212583144400_DEV202146C68","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/366461a0","article-title":"A C. elegans mutant that lives twice as long as wild type","volume":"366","author":"Kenyon","year":"1993","journal-title":"Nature"},{"key":"2024021212583144400_DEV202146C69","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1038\/ng.2763","article-title":"Dampening of expression oscillations by synchronous regulation of a microRNA and its target","volume":"45","author":"Kim","year":"2013","journal-title":"Nat. Genet."},{"key":"2024021212583144400_DEV202146C70","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1126\/science.277.5328.942","article-title":"Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans","volume":"277","author":"Kimura","year":"1997","journal-title":"Science"},{"key":"2024021212583144400_DEV202146C71","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1101\/sqb.2011.76.010660","article-title":"The C. elegans DAF-2 insulin-like receptor is abundantly expressed in the nervous system and regulated by nutritional status","volume":"76","author":"Kimura","year":"2011","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"2024021212583144400_DEV202146C72","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/0047-6374(77)90043-4","article-title":"Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span","volume":"6","author":"Klass","year":"1977","journal-title":"Mech. Ageing Dev."},{"key":"2024021212583144400_DEV202146C73","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/0047-6374(83)90082-9","article-title":"A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results","volume":"22","author":"Klass","year":"1983","journal-title":"Mech. Ageing Dev."},{"key":"2024021212583144400_DEV202146C74","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/260523a0","article-title":"Non-ageing developmental variant of Caenorhabditis elegans","volume":"260","author":"Klass","year":"1976","journal-title":"Nature"},{"key":"2024021212583144400_DEV202146C75","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s12861-018-0162-8","article-title":"Cell cycle accumulation of the proliferating cell nuclear antigen PCN-1 transitions from continuous in the adult germline to intermittent in the early embryo of C. elegans","volume":"18","author":"Kocsisova","year":"2018","journal-title":"BMC Dev. Biol."},{"key":"2024021212583144400_DEV202146C76","doi-asserted-by":"publisher","first-page":"e1005866","DOI":"10.1371\/journal.pgen.1005866","article-title":"Angiotensin converting enzyme (ACE) inhibitor extends Caenorhabditis elegans life span","volume":"12","author":"Kumar","year":"2016","journal-title":"PLoS Genet."},{"key":"2024021212583144400_DEV202146C77","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/nature09184","article-title":"A new DAF-16 isoform regulates longevity","volume":"466","author":"Kwon","year":"2010","journal-title":"Nature"},{"key":"2024021212583144400_DEV202146C78","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1002\/dvdy.22244","article-title":"Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16\/FOXO","volume":"239","author":"Landis","year":"2010","journal-title":"Dev. Dyn."},{"key":"2024021212583144400_DEV202146C79","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"2024021212583144400_DEV202146C80","doi-asserted-by":"publisher","first-page":"8905","DOI":"10.1073\/pnas.90.19.8905","article-title":"Aging and resistance to oxidative damage in Caenorhabditis elegans","volume":"90","author":"Larsen","year":"1993","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2024021212583144400_DEV202146C81","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1093\/genetics\/139.4.1567","article-title":"Genes that regulate both development and longevity in Caenorhabditis elegans","volume":"139","author":"Larsen","year":"1995","journal-title":"Genetics"},{"key":"2024021212583144400_DEV202146C82","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1016\/S0960-9822(01)00595-4","article-title":"Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway","volume":"11","author":"Lee","year":"2001","journal-title":"Curr. Biol."},{"key":"2024021212583144400_DEV202146C83","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1002\/cne.901720306","article-title":"Specific neuroanatomical changes in chemosensory mutants of the nematode Caenorhabditis elegans","volume":"172","author":"Lewis","year":"1977","journal-title":"J. Comp. Neurol."},{"key":"2024021212583144400_DEV202146C84","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/S0092-8674(03)00889-4","article-title":"Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan","volume":"115","author":"Libina","year":"2003","journal-title":"Cell"},{"key":"2024021212583144400_DEV202146C85","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1126\/science.278.5341.1319","article-title":"daf-16: an HNF-3\/forkhead family member that can function to double the life-span of Caenorhabditis elegans","volume":"278","author":"Lin","year":"1997","journal-title":"Science"},{"key":"2024021212583144400_DEV202146C86","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/88850","article-title":"Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin\/IGF-1 and germline signaling","volume":"28","author":"Lin","year":"2001","journal-title":"Nat. Genet."},{"key":"2024021212583144400_DEV202146C87","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1002\/jez.a.324","article-title":"Xenobiotic detoxification in the nematode Caenorhabditis elegans","volume":"305A","author":"Lindblom","year":"2006","journal-title":"J. Exp. Zool. Part A: Comp. Exp. Biol."},{"key":"2024021212583144400_DEV202146C88","doi-asserted-by":"publisher","first-page":"7540","DOI":"10.1073\/pnas.92.16.7540","article-title":"Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress","volume":"92","author":"Lithgow","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024021212583144400_DEV202146C89","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1093\/hmg\/11.12.1465","article-title":"Genotype\u2013phenotype correlation in inherited severe insulin resistance","volume":"11","author":"Longo","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"2024021212583144400_DEV202146C90","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.arr.2012.06.006","article-title":"Pharmacological lifespan extension of invertebrates","volume":"12","author":"Lucanic","year":"2013","journal-title":"Ageing Res. Rev."},{"key":"2024021212583144400_DEV202146C91","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1038\/nchembio.698","article-title":"Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans","volume":"7","author":"Luciani","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"2024021212583144400_DEV202146C92","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1895\/wormbook.1.155.1","article-title":"Ascaroside signaling in C. elegans","volume-title":"WormBook: The Online Review of C. elegans Biology","author":"Ludewig","year":"2018"},{"key":"2024021212583144400_DEV202146C93","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1101\/gad.312604","article-title":"A novel nuclear receptor\/coregulator complex controls C. elegans lipid metabolism, larval development, and aging","volume":"18","author":"Ludewig","year":"2004","journal-title":"Genes Dev."},{"key":"2024021212583144400_DEV202146C94","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/dvg.20694","article-title":"Caenorhabditis elegans reproductive aging: regulation and underlying mechanisms","volume":"49","author":"Luo","year":"2011","journal-title":"Genesis"},{"key":"2024021212583144400_DEV202146C95","first-page":"163","article-title":"Evaluation of survival data and two new rank order statistics arising in its consideration","volume":"50","author":"Mantel","year":"1966","journal-title":"Cancer Chemother. Rep."},{"key":"2024021212583144400_DEV202146C96","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.cmet.2009.04.002","article-title":"Live Longer sans the AT1A Receptor","volume":"9","author":"Mattson","year":"2009","journal-title":"Cell Metab."},{"key":"2024021212583144400_DEV202146C97","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1080\/15384101.2017.1344798","article-title":"acn-1, a C. elegans homologue of ACE, genetically interacts with the let-7 microRNA and other heterochronic genes","volume":"16","author":"Metheetrairut","year":"2017","journal-title":"Cell Cycle"},{"key":"2024021212583144400_DEV202146C98","doi-asserted-by":"publisher","first-page":"e57142","DOI":"10.1371\/journal.pone.0057142","article-title":"WormSizer: high-throughput analysis of nematode size and shape","volume":"8","author":"Moore","year":"2013","journal-title":"PLoS One"},{"key":"2024021212583144400_DEV202146C99","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1016\/j.cell.2006.01.037","article-title":"Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans","volume":"124","author":"Motola","year":"2006","journal-title":"Cell"},{"key":"2024021212583144400_DEV202146C100","doi-asserted-by":"publisher","first-page":"3280","DOI":"10.1093\/ndt\/gfp381","article-title":"Angiotensin II type 1A receptor deficiency and longevity","volume":"24","author":"Nishiyama","year":"2009","journal-title":"Nephrol. Dial. Transplant."},{"key":"2024021212583144400_DEV202146C101","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1038\/40194","article-title":"The fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans","volume":"389","author":"Ogg","year":"1997","journal-title":"Nature"},{"key":"2024021212583144400_DEV202146C102","doi-asserted-by":"publisher","first-page":"4494","DOI":"10.1073\/pnas.0500749102","article-title":"JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor\/DAF-16","volume":"102","author":"Oh","year":"2005","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2024021212583144400_DEV202146C103","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1126\/science.1250709","article-title":"Role of synaptic phosphatidylinositol 3-kinase in a behavioral learning response in C. elegans","volume":"345","author":"Ohno","year":"2014","journal-title":"Science"},{"key":"2024021212583144400_DEV202146C104","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1126\/science.191908","article-title":"Design of specific inhibitors of angiotensin-converting enzyme: new class of orally active antihypertensive agents","volume":"196","author":"Ondetti","year":"1977","journal-title":"Science"},{"key":"2024021212583144400_DEV202146C105","doi-asserted-by":"publisher","first-page":"18403","DOI":"10.1074\/jbc.M410928200","article-title":"Regulation of sphingosine-1-phosphate lyase gene expression by members of the GATA family of transcription factors","volume":"280","author":"Oskouian","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2024021212583144400_DEV202146C106","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1093\/bioinformatics\/btm076","article-title":"COBALT: constraint-based alignment tool for multiple protein sequences","volume":"23","author":"Papadopoulos","year":"2007","journal-title":"Bioinformatics"},{"key":"2024021212583144400_DEV202146C107","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/s41573-020-0067-7","article-title":"The quest to slow ageing through drug discovery","volume":"19","author":"Partridge","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"2024021212583144400_DEV202146C108","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1534\/genetics.107.070813","article-title":"Clustering of genetically defined allele classes in the Caenorhabditis elegans DAF-2 insulin\/IGF-1 receptor","volume":"178","author":"Patel","year":"2008","journal-title":"Genetics"},{"key":"2024021212583144400_DEV202146C109","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1152\/physrev.1977.57.2.313","article-title":"Renin angiotensin system: biochemistry and mechanisms of action","volume":"57","author":"Peach","year":"1977","journal-title":"Physiol. Rev."},{"key":"2024021212583144400_DEV202146C110","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1101\/gad.867301","article-title":"Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family","volume":"15","author":"Pierce","year":"2001","journal-title":"Genes Dev."},{"key":"2024021212583144400_DEV202146C111","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1146\/annurev.ph.40.030178.002113","article-title":"The renin-angiotensin system","volume":"40","author":"Reid","year":"1978","journal-title":"Ann. Rev. Physiol."},{"key":"2024021212583144400_DEV202146C112","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.mad.2018.06.002","article-title":"Review and meta-analysis of genetic polymorphisms associated with exceptional human longevity","volume":"175","author":"Revelas","year":"2018","journal-title":"Mech. Ageing Dev."},{"key":"2024021212583144400_DEV202146C113","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/290668a0","article-title":"Interacting genes in nematode dauer larva formation","volume":"290","author":"Riddle","year":"1981","journal-title":"Nature"},{"key":"2024021212583144400_DEV202146C114","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1172\/JCI114844","article-title":"An insertion\/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels","volume":"86","author":"Rigat","year":"1990","journal-title":"J. Clin. Invest."},{"key":"2024021212583144400_DEV202146C115","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.cmet.2012.04.007","article-title":"TOR signaling and rapamycin influence longevity by regulating SKN-1\/Nrf and DAF-16\/FoxO","volume":"15","author":"Robida-Stubbs","year":"2012","journal-title":"Cell Metab."},{"key":"2024021212583144400_DEV202146C116","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.bcp.2009.06.018","article-title":"Long term treatment with ACE inhibitor enalapril decreases body weight gain and increases life span in rats","volume":"78","author":"Santos","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"2024021212583144400_DEV202146C117","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative CT method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"2024021212583144400_DEV202146C118","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.1101\/gad.1218504","article-title":"Identification of C. elegans DAF-12-binding sites, response elements, and target genes","volume":"18","author":"Shostak","year":"2004","journal-title":"Genes Dev."},{"key":"2024021212583144400_DEV202146C119","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ydbio.2004.09.026","article-title":"The evolutionary origin of cardiac chambers","volume":"277","author":"Sim\u00f5es-Costa","year":"2005","journal-title":"Dev. Biol."},{"key":"2024021212583144400_DEV202146C120","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1084\/jem.103.3.295","article-title":"The preparation and function of the hypertensin-converting enzyme","volume":"103","author":"Skeggs","year":"1956","journal-title":"J. Exp. Med."},{"key":"2024021212583144400_DEV202146C121","doi-asserted-by":"publisher","first-page":"e13724","DOI":"10.1111\/acel.13724","article-title":"Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice","volume":"21","author":"Strong","year":"2022","journal-title":"Aging Cell"},{"key":"2024021212583144400_DEV202146C122","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/0012-1606(81)90367-5","article-title":"Critical periods in the development of the Caenorhabditis elegans dauer larva","volume":"84","author":"Swanson","year":"1981","journal-title":"Dev. Biol."},{"key":"2024021212583144400_DEV202146C123","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1146\/annurev.physiol.70.113006.100533","article-title":"Insulin-like signaling, nutrient homeostasis, and life span","volume":"70","author":"Taguchi","year":"2008","journal-title":"Annu. Rev. Physiol."},{"key":"2024021212583144400_DEV202146C124","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1126\/science.1057987","article-title":"A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function","volume":"292","author":"Tatar","year":"2001","journal-title":"Science"},{"key":"2024021212583144400_DEV202146C125","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1093\/genetics\/134.4.1105","article-title":"Evidence for parallel processing of sensory information controlling dauer formation in Caenorhabditis elegans","volume":"134","author":"Thomas","year":"1993","journal-title":"Genetics"},{"key":"2024021212583144400_DEV202146C126","first-page":"1","article-title":"Chapter one - DAF-16: FOXO in the context of C. elegans","volume-title":"Current Topics in Developmental Biology, Forkhead FOXO Transcription Factors in Development and Disease","author":"Tissenbaum","year":"2018"},{"key":"2024021212583144400_DEV202146C127","doi-asserted-by":"publisher","first-page":"e1004109","DOI":"10.1371\/journal.pgen.1004109","article-title":"DAF-16\/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin\/IGF-1 signaling on aging in Caenorhabditis elegans","volume":"10","author":"Tullet","year":"2014","journal-title":"PLoS Genet."},{"key":"2024021212583144400_DEV202146C128","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1093\/genetics\/130.1.105","article-title":"Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans","volume":"130","author":"Vowels","year":"1992","journal-title":"Genetics"},{"key":"2024021212583144400_DEV202146C129","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/ng1723","article-title":"Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation","volume":"38","author":"Wook Oh","year":"2006","journal-title":"Nat. Genet."},{"key":"2024021212583144400_DEV202146C130","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1126\/science.abb2507","article-title":"Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation","volume":"367","author":"Wrapp","year":"2020","journal-title":"Science"},{"key":"2024021212583144400_DEV202146C131","doi-asserted-by":"publisher","first-page":"9839","DOI":"10.1038\/s41598-017-10454-3","article-title":"An enhanced C. elegans based platform for toxicity assessment","volume":"7","author":"Xiong","year":"2017","journal-title":"Sci. Rep."},{"key":"2024021212583144400_DEV202146C132","doi-asserted-by":"publisher","first-page":"14453","DOI":"10.1038\/srep14453","article-title":"Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression","volume":"5","author":"Yabumoto","year":"2015","journal-title":"Sci. Rep."},{"key":"2024021212583144400_DEV202146C133","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1016\/S0047-6374(02)00093-3","article-title":"Adaptive responses to oxidative damage in three mutants of Caenorhabditis elegans (age-1, mev-1 and daf-16) that affect life span","volume":"123","author":"Yanase","year":"2002","journal-title":"Mech. Ageing Dev."},{"key":"2024021212583144400_DEV202146C134","volume-title":"Basic and Clinical Pharmacology","author":"Zehnder","year":"2009"},{"key":"2024021212583144400_DEV202146C135","doi-asserted-by":"publisher","first-page":"e25081","DOI":"10.4161\/worm.25081","article-title":"Deep sequencing strategies for mapping and identifying mutations from genetic screens","volume":"2","author":"Zuryn","year":"2013","journal-title":"Worm"},{"key":"2024021212583144400_DEV202146C136","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1534\/genetics.110.119230","article-title":"A strategy for direct mapping and identification of mutations by whole-genome sequencing","volume":"186","author":"Zuryn","year":"2010","journal-title":"Genetics"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.202146\/3360753\/dev202146.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.202146\/3366988\/dev202146.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.202146\/3366988\/dev202146.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T07:58:46Z","timestamp":1707724726000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/151\/3\/dev202146\/343016\/The-ACE-inhibitor-captopril-inhibits-ACN-1-to"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,1]]},"references-count":136,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,2,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.202146","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.07.17.549402","asserted-by":"object"}]},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,1]]},"article-number":"dev202146"}}