{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:04:13Z","timestamp":1791561853643,"version":"4.3.4"},"reference-count":36,"publisher":"The Company of Biologists","issue":"23","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82171628"],"award-info":[{"award-number":["82171628"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002799","name":"Capital Medical University","doi-asserted-by":"crossref","award":["B2205"],"award-info":[{"award-number":["B2205"]}],"id":[{"id":"10.13039\/501100002799","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Beijing Hospital Authority","award":["QML20201401"],"award-info":[{"award-number":["QML20201401"]}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"crossref","award":["2021YFA0719301"],"award-info":[{"award-number":["2021YFA0719301"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"crossref","award":["2022YFA0806301"],"award-info":[{"award-number":["2022YFA0806301"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Infertility affects couples worldwide. Premature ovarian insufficiency (POI) refers to loss of ovarian function before 40\u2005years of age and is a contributing factor to infertility. Several case studies have reported dominant-inherited POI symptoms in families with heterozygous EIF4ENIF1 (4E-T) mutations. However, the effects of EIF4ENIF1 haploinsufficiency have rarely been studied in animal models to reveal the underlying molecular changes related to infertility. Here, we demonstrate that Eif4enif1 haploinsufficiency causes mouse subfertility, impairs oocyte maturation and partially arrests early embryonic development. Using dual-omic sequencing, we observed that Eif4enif1 haploinsufficiency significantly altered both transcriptome and translatome in mouse oocytes, by which we further revealed oocyte mitochondrial hyperfusion and mitochondria-associated ribonucleoprotein domain distribution alteration in Eif4enif1-deficient oocytes. This study provides new insights into the molecular mechanisms underlying clinical fertility failure and new avenues to pursue new therapeutic targets to address infertility.<\/jats:p>","DOI":"10.1242\/dev.202151","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T09:10:10Z","timestamp":1702458610000},"source":"Crossref","is-referenced-by-count":24,"title":["<i>Eif4enif1<\/i> haploinsufficiency disrupts oocyte mitochondrial dynamics and leads to subfertility"],"prefix":"10.1242","volume":"150","author":[{"given":"Yuxi","family":"Ding","sequence":"first","affiliation":[{"name":"The State Key Laboratory for Complex, Severe, and Rare Diseases; SXMU-Tsinghua Collaborative Innovation Center for Frontier Medicine 1 , Department of Basic Medical Sciences , , Beijing 100084 , China"},{"name":"School of Medicine, Tsinghua University 1 , Department of Basic Medical Sciences , , Beijing 100084 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zequn","family":"He","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Center for Life Sciences, Tsinghua University 2 , Beijing 100084 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwei","family":"Sha","sequence":"additional","affiliation":[{"name":"Women and Children's Hospital, School of Medicine, Xiamen University 3 Department of Andrology , , Xiamen, Fujian 361005 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6926-7203","authenticated-orcid":false,"given":"Kehkooi","family":"Kee","sequence":"additional","affiliation":[{"name":"The State Key Laboratory for Complex, Severe, and Rare Diseases; SXMU-Tsinghua Collaborative Innovation Center for Frontier Medicine 1 , Department of Basic Medical Sciences , , Beijing 100084 , China"},{"name":"School of Medicine, Tsinghua University 1 , Department of Basic Medical Sciences , , Beijing 100084 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3597-3350","authenticated-orcid":false,"given":"Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital 4 Central Laboratory , , Beijing 100006 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2023,12,13]]},"reference":[{"key":"2023121309055431100_DEV202151C1","doi-asserted-by":"publisher","first-page":"eabl8070","DOI":"10.1126\/sciadv.abl8070","article-title":"Depletion of oocyte dynamin-related protein 1 shows maternal-effect abnormalities in embryonic development","volume":"8","author":"Adhikari","year":"2022","journal-title":"Sci. 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Ovarian Res."}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.202151\/3295229\/dev202151.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.202151\/3295229\/dev202151.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T09:10:14Z","timestamp":1702458614000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/150\/23\/dev202151\/336522\/Eif4enif1-haploinsufficiency-disrupts-oocyte"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,1]]},"references-count":36,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2023,12,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.202151","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,1]]},"article-number":"dev202151"}}