{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:22:08Z","timestamp":1784679728946,"version":"3.55.0"},"reference-count":40,"publisher":"The Company of Biologists","issue":"3","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"National Science Foundation","award":["2045759"],"award-info":[{"award-number":["2045759"]}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"crossref","award":["R01NS092096"],"award-info":[{"award-number":["R01NS092096"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"crossref","award":["R37MH085726"],"award-info":[{"award-number":["R37MH085726"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Cancer Institute","award":["P30 CA008748-48"],"award-info":[{"award-number":["P30 CA008748-48"]}]},{"DOI":"10.13039\/100007250","name":"Mississippi State University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007250","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Modeling has led to proposals that the amount of neural tissue folding is set by the level of differential expansion between tissue layers and that the wavelength is set by the thickness of the outer layer. Here, we used inbred mouse strains with distinct amounts of cerebellar folding to investigate these predictions. We identified a distinct critical period during which the folding amount diverges between the two strains. In this period, regional changes in the level of differential expansion between the external granule layer (EGL) and underlying core correlate with the folding amount in each strain. Additionally, the thickness of the EGL varies regionally during the critical period alongside corresponding changes in wavelength. The number of SHH-expressing Purkinje cells predicts the folding amount, but the proliferation rate in the EGL is the same between the strains. However, regional changes in the cell division angle within the EGL predicts both the tangential expansion and the thickness of the EGL. Cell division angle is likely a tunable mechanism whereby both the level of differential expansion along the perimeter and the thickness of the EGL are regionally tuned to set the amount and wavelength of folding.<\/jats:p>","DOI":"10.1242\/dev.202184","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T13:39:13Z","timestamp":1705930753000},"source":"Crossref","is-referenced-by-count":5,"title":["Cell division angle predicts the level of tissue mechanics that tune the amount of cerebellar folding"],"prefix":"10.1242","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5351-2858","authenticated-orcid":false,"given":"Amber G.","family":"Cook","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Mississippi State University 1 , MS 39762 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor V.","family":"Bishop","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Mississippi State University 1 , MS 39762 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2868-5306","authenticated-orcid":false,"given":"Hannah R.","family":"Crowe","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Mississippi State University 1 , MS 39762 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel N.","family":"Stevens","sequence":"additional","affiliation":[{"name":"Sloan Kettering Institute 2 Developmental Biology Program , , NY 10065 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Reine","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Mississippi State University 1 , MS 39762 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7090-9605","authenticated-orcid":false,"given":"Alexandra L.","family":"Joyner","sequence":"additional","affiliation":[{"name":"Sloan Kettering Institute 2 Developmental Biology Program , , NY 10065 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8633-6637","authenticated-orcid":false,"given":"Andrew K.","family":"Lawton","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Mississippi State University 1 , MS 39762 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"key":"2024021609542150700_DEV202184C1","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/347677a0","article-title":"Retinal degeneration in the rd mouse is caused by a defect in the \u03b2 subunit of rod cGMP-phosphodiesterase","volume":"347","author":"Bowes","year":"1990","journal-title":"Nature"},{"key":"2024021609542150700_DEV202184C2","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1242\/dev.02351","article-title":"The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation","volume":"133","author":"Corrales","year":"2006","journal-title":"Development"},{"key":"2024021609542150700_DEV202184C3","doi-asserted-by":"publisher","first-page":"041053","DOI":"10.1103\/PhysRevX.8.041053","article-title":"Buckling without bending: a new paradigm in morphogenesis","volume":"8","author":"Engstrom","year":"2018","journal-title":"Phys. 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