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Its precise and dynamic assembly is pivotal for its function. Spliceosome malfunctions can lead to developmental abnormalities and potentially contribute to tumorigenesis. The specific role of the spliceosome in B cell development is poorly understood. Here, we reveal that the spliceosomal U2 snRNP component PHD finger protein 5A (Phf5a) is vital for early B cell development. Loss of Phf5a results in pronounced defects in B cell development, causing an arrest at the transition from pre-pro-B to early pro-B cell stage in the bone marrow of mutant mice. Phf5a-deficient B cells exhibit impaired immunoglobulin heavy (IgH) chain expression due to defective V-to-DJ gene rearrangement. Mechanistically, our findings suggest that Phf5a facilitates IgH gene rearrangement by regulating the activity of recombination-activating gene endonuclease and influencing chromatin interactions at the Igh locus.<\/jats:p>","DOI":"10.1242\/dev.202247","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T12:35:40Z","timestamp":1702557340000},"source":"Crossref","is-referenced-by-count":2,"title":["Spliceosome component PHD finger 5A is essential for early B lymphopoiesis"],"prefix":"10.1242","volume":"151","author":[{"given":"Rui","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Life Sciences, Southern University of Science and Technology 1 Department of Immunology and Microbiology , , Shenzhen 518055 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoqin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Southern University of Science and Technology 1 Department of Immunology and Microbiology , , Shenzhen 518055 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Xin","family":"Ruan","sequence":"additional","affiliation":[{"name":"Medical School, Taizhou University 2 , Taizhou 318000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruisi","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Southern University of Science and Technology 1 Department of Immunology and Microbiology , , Shenzhen 518055 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxing","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Southern University of Science and Technology 1 Department of Immunology and Microbiology , , Shenzhen 518055 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Southern University of Science and Technology 1 Department of Immunology and Microbiology , , Shenzhen 518055 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengjun","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Southern University of Science and Technology 1 Department of Immunology and Microbiology , , Shenzhen 518055 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Southern University of Science and Technology 1 Department of Immunology and Microbiology , , Shenzhen 518055 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Meng","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Southern University of Science and Technology 1 Department of Immunology and Microbiology , , Shenzhen 518055 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Southern University of Science and Technology 1 Department of Immunology and Microbiology , , Shenzhen 518055 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengfeng","family":"Lei","sequence":"additional","affiliation":[{"name":"Southern University of Science and Technology Hospital 3 Department of Ophthalmology , , Shenzhen 518055 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2541-3608","authenticated-orcid":false,"given":"Shengli","family":"Xu","sequence":"additional","affiliation":[{"name":"Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR) 4 , 8A Biomedical Grove, Immunos, Singapore 138648 , Republic of Singapore"},{"name":"Yong Loo Lin School of Medicine, National University of Singapore 5 Department of Physiology , , 2 Medical Drive MD9, Singapore 117593 , Republic of Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4525-5205","authenticated-orcid":false,"given":"Xijun","family":"Ou","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Southern University of Science and Technology 1 Department of Immunology and Microbiology , , Shenzhen 518055 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2024,1,11]]},"reference":[{"key":"2024061306360359600_DEV202247C1","doi-asserted-by":"publisher","first-page":"2439","DOI":"10.4049\/jimmunol.176.4.2439","article-title":"Regulation of IgH gene assembly: role of the intronic enhancer and 5'DQ52 region in targeting DHJH recombination","volume":"176","author":"Afshar","year":"2006","journal-title":"J. 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