{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:27:02Z","timestamp":1753889222036,"version":"3.41.2"},"reference-count":39,"publisher":"The Company of Biologists","issue":"4","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["217093\/Z\/19\/Z"],"award-info":[{"award-number":["217093\/Z\/19\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Medical Research Council","award":["MR\/V010972\/1"],"award-info":[{"award-number":["MR\/V010972\/1"]}]},{"DOI":"10.13039\/501100000853","name":"University of Glasgow","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000853","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>ACKR3 scavenges and degrades the stem cell recruiting chemokine CXCL12, which is essential for proper embryonic and, in particular, haematopoietic development. Here, we demonstrate strong expression of ACKR3 on trophoblasts. Using a maternally administered pharmacological blocker and Cre-mediated genetic approaches, we demonstrate that trophoblast ACKR3 is essential for preventing movement of CXCL12 from the mother to the embryo, with elevated plasma CXCL12 levels being detected in embryos from ACKR3-blocker-treated mothers. Mice born to mothers treated with the blocker are lighter and shorter than those born to vehicle-treated mothers and, in addition, display profound anaemia associated with a markedly reduced bone marrow haematopoietic stem cell population. Importantly, although the haematopoietic abnormalities are corrected as mice age, our studies reveal a postnatal window during which offspring of ACKR3-blocker-treated mice are unable to mount effective inflammatory responses to inflammatory\/infectious stimuli. Overall, these data demonstrate that ACKR3 is essential for preventing CXCL12 transfer from mother to embryo and for ensuring properly regulated CXCL12 control over the development of the haematopoietic system.<\/jats:p>","DOI":"10.1242\/dev.202333","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T17:49:36Z","timestamp":1706809776000},"source":"Crossref","is-referenced-by-count":5,"title":["Disruption of placental ACKR3 impairs growth and hematopoietic development of offspring"],"prefix":"10.1242","volume":"151","author":[{"given":"Ayumi","family":"Fukuoka","sequence":"first","affiliation":[{"name":", College of Medical, Veterinary and Life Sciences, University of Glasgow Chemokine Research Group, School of Infection and Immunity , 120 University Place, Glasgow G12 8TA , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9513-8437","authenticated-orcid":false,"given":"Gillian J.","family":"Wilson","sequence":"additional","affiliation":[{"name":", College of Medical, Veterinary and Life Sciences, University of Glasgow Chemokine Research Group, School of Infection and Immunity , 120 University Place, Glasgow G12 8TA , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise","family":"Pitmon","sequence":"additional","affiliation":[{"name":", College of Medical, Veterinary and Life Sciences, University of Glasgow Chemokine Research Group, School of Infection and Immunity , 120 University Place, Glasgow G12 8TA , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lily","family":"Koumbas Foley","sequence":"additional","affiliation":[{"name":", College of Medical, Veterinary and Life Sciences, University of Glasgow Chemokine Research Group, School of Infection and Immunity , 120 University Place, Glasgow G12 8TA , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Johnsson","sequence":"additional","affiliation":[{"name":", College of Medical, Veterinary and Life Sciences, University of Glasgow Chemokine Research Group, School of Infection and Immunity , 120 University Place, Glasgow G12 8TA , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marieke","family":"Pingen","sequence":"additional","affiliation":[{"name":", College of Medical, Veterinary and Life Sciences, University of Glasgow Chemokine Research Group, School of Infection and Immunity , 120 University Place, Glasgow G12 8TA , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7801-204X","authenticated-orcid":false,"given":"Gerard J.","family":"Graham","sequence":"additional","affiliation":[{"name":", College of Medical, Veterinary and Life Sciences, University of Glasgow Chemokine Research Group, School of Infection and Immunity , 120 University Place, Glasgow G12 8TA , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"key":"2024030409490548800_DEV202333C1","doi-asserted-by":"publisher","first-page":"2096","DOI":"10.3390\/cells12162096","article-title":"Variable cre recombination efficiency in placentas of Cyp19-Cre ROSAmT\/mG transgenic mice","volume":"12","author":"Anamthathmakula","year":"2023","journal-title":"Cells"},{"key":"2024030409490548800_DEV202333C2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1124\/pr.113.007724","article-title":"International union of pharmacology. 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