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Deleting one module results in small organoids, recapitulating the small-eyed phenotype of mice with microphthalmia, while deletion of the other module led to disruptions in bipolar neuron development. This prototypical SE serves as a model for understanding developmental stage- and cell type-specific effects of neurogenic transcription factors with complex expression patterns. Moreover, by elucidating the gene regulatory mechanisms, we can begin to examine how dysregulation of these mechanisms contributes to phenotypic diversity and disease.<\/jats:p>","DOI":"10.1242\/dev.202435","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T06:06:55Z","timestamp":1720764415000},"source":"Crossref","is-referenced-by-count":8,"title":["Evolutionary conservation of VSX2 super-enhancer modules in retinal development"],"prefix":"10.1242","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2742-2951","authenticated-orcid":false,"given":"Victoria","family":"Honnell","sequence":"first","affiliation":[{"name":"St. Jude Children's Research Hospital 1 Department of Developmental Neurobiology at , Memphis, TN 38105 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Sweeney","sequence":"additional","affiliation":[{"name":"St. Jude Children's Research Hospital 1 Department of Developmental Neurobiology at , Memphis, TN 38105 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1021-0306","authenticated-orcid":false,"given":"Jackie","family":"Norrie","sequence":"additional","affiliation":[{"name":"St. Jude Children's Research Hospital 1 Department of Developmental Neurobiology at , Memphis, TN 38105 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison","family":"Parks","sequence":"additional","affiliation":[{"name":"St. Jude Children's Research Hospital 1 Department of Developmental Neurobiology at , Memphis, TN 38105 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5598-0876","authenticated-orcid":false,"given":"Cody","family":"Ramirez","sequence":"additional","affiliation":[{"name":"St. Jude Children's Research Hospital 1 Department of Developmental Neurobiology at , Memphis, TN 38105 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asha Jacob","family":"Jannu","sequence":"additional","affiliation":[{"name":"St. Jude Children's Research Hospital 1 Department of Developmental Neurobiology at , Memphis, TN 38105 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0099-858X","authenticated-orcid":false,"given":"Beisi","family":"Xu","sequence":"additional","affiliation":[{"name":"Center for Applied Bioinformatics at St. Jude Children's Research Hospital 2 , Memphis, TN 38105 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Teubner","sequence":"additional","affiliation":[{"name":"St. Jude Children's Research Hospital 1 Department of Developmental Neurobiology at , Memphis, TN 38105 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ah Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Wilmer Eye Institute, Johns Hopkins University School of Medicine 3 , Baltimore, MD 21231 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Bell","sequence":"additional","affiliation":[{"name":"Wilmer Eye Institute, Johns Hopkins University School of Medicine 3 , Baltimore, MD 21231 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4027-4850","authenticated-orcid":false,"given":"Michael A.","family":"Dyer","sequence":"additional","affiliation":[{"name":"St. Jude Children's Research Hospital 1 Department of Developmental Neurobiology at , Memphis, TN 38105 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2024,7,12]]},"reference":[{"key":"2024071210130898100_DEV202435C1","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.neuron.2017.04.022","article-title":"The dynamic epigenetic landscape of the retina during development, reprogramming, and tumorigenesis","volume":"94","author":"Aldiri","year":"2017","journal-title":"Neuron"},{"key":"2024071210130898100_DEV202435C2","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1242\/dev.014142","article-title":"Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF","volume":"135","author":"Bharti","year":"2008","journal-title":"Development"},{"key":"2024071210130898100_DEV202435C3","doi-asserted-by":"publisher","first-page":"4221","DOI":"10.1038\/s41467-019-11950-y","article-title":"Identification of significant chromatin contacts from HiChIP data by FitHiChIP","volume":"10","author":"Bhattacharyya","year":"2019","journal-title":"Nat. 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