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RGC axon segregation occurs at the optic chiasm, which forms at the ventral diencephalon midline. Using expression analyses, retinal explants and genetically modified mice, we demonstrate that CXCL12 (SDF1) is required for axon segregation at the optic chiasm. CXCL12 is expressed by the meninges bordering the optic pathway, and CXCR4 by both ipsilaterally and contralaterally projecting RGCs. CXCL12 or ventral diencephalon meninges potently promoted axon outgrowth from both ipsilaterally and contralaterally projecting RGCs. Further, a higher proportion of axons projected ipsilaterally in mice lacking CXCL12 or its receptor CXCR4 compared with wild-type mice as a result of misrouting of presumptive contralaterally specified RGC axons. Although RGCs also expressed the alternative CXCL12 receptor ACKR3, the optic chiasm developed normally in mice lacking ACKR3. Our data support a model whereby meningeal-derived CXCL12 helps drive axon growth from CXCR4-expressing RGCs towards the diencephalon midline, enabling contralateral axon growth. These findings further our understanding of the molecular and cellular mechanisms controlling optic pathway development.<\/jats:p>","DOI":"10.1242\/dev.202446","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T12:35:42Z","timestamp":1702557342000},"source":"Crossref","is-referenced-by-count":7,"title":["CXCL12 promotes the crossing of retinal ganglion cell axons at the optic chiasm"],"prefix":"10.1242","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0876-5983","authenticated-orcid":false,"given":"Viet-Hang","family":"Le","sequence":"first","affiliation":[{"name":"University of Aberdeen, 1 School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences , Foresterhill, Aberdeen AB25 2ZD , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2585-3179","authenticated-orcid":false,"given":"Clarisse","family":"Orniacki","sequence":"additional","affiliation":[{"name":"University of Aberdeen, 1 School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences , Foresterhill, Aberdeen AB25 2ZD , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5588-7057","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"Murcia-Belmonte","sequence":"additional","affiliation":[{"name":"University of Aberdeen, 1 School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences , Foresterhill, Aberdeen AB25 2ZD , UK"},{"name":"Instituto de Neurociencias de Alicante (Consejo Superior de Investigaciones Cient\u00edficas-Universidad Miguel Hern\u00e1ndez, CSIC-UMH) 2 , Campus San Juan, Av. 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