{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T01:55:16Z","timestamp":1777082116522,"version":"3.51.4"},"reference-count":75,"publisher":"The Company of Biologists","issue":"10","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 HD095520"],"award-info":[{"award-number":["R01 HD095520"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Neurulation is a highly synchronized biomechanical process leading to the formation of the brain and spinal cord, and its failure leads to neural tube defects (NTDs). Although we are rapidly learning the genetic mechanisms underlying NTDs, the biomechanical aspects are largely unknown. To understand the correlation between NTDs and tissue stiffness during neural tube closure (NTC), we imaged an NTD murine model using optical coherence tomography (OCT), Brillouin microscopy and confocal fluorescence microscopy. Here, we associate structural information from OCT with local stiffness from the Brillouin signal of embryos undergoing neurulation. The stiffness of neuroepithelial tissues in Mthfd1l null embryos was significantly lower than that of wild-type embryos. Additionally, exogenous formate supplementation improved tissue stiffness and gross embryonic morphology in nullizygous and heterozygous embryos. Our results demonstrate the significance of proper tissue stiffness in normal NTC and pave the way for future studies on the mechanobiology of normal and abnormal embryonic development.<\/jats:p>","DOI":"10.1242\/dev.202475","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T08:12:16Z","timestamp":1714378336000},"source":"Crossref","is-referenced-by-count":4,"title":["Optical coherence tomography-guided Brillouin microscopy highlights regional tissue stiffness differences during anterior neural tube closure in the <i>Mthfd1l<\/i> murine mutant"],"prefix":"10.1242","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4266-4924","authenticated-orcid":false,"given":"Yogeshwari S.","family":"Ambekar","sequence":"first","affiliation":[{"name":"University of Houston 1 Department of Biomedical Engineering , , Houston, TX 77204 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo Donato","family":"Caiaffa","sequence":"additional","affiliation":[{"name":"Center for Precision Environmental Health, Baylor College of Medicine 2 , Houston, TX 77030 , USA"},{"name":"Department of Pediatrics, Dell Pediatric Research Institute, Dell Medical School, University of Texas at Austin 3 , Austin, TX 78723 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan J.","family":"Wlodarczyk","sequence":"additional","affiliation":[{"name":"Center for Precision Environmental Health, Baylor College of Medicine 2 , Houston, TX 77030 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manmohan","family":"Singh","sequence":"additional","affiliation":[{"name":"University of Houston 1 Department of Biomedical Engineering , , Houston, TX 77204 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander W.","family":"Schill","sequence":"additional","affiliation":[{"name":"University of Houston 1 Department of Biomedical Engineering , , Houston, TX 77204 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W.","family":"Steele","sequence":"additional","affiliation":[{"name":"Center for Precision Environmental Health, Baylor College of Medicine 2 , Houston, TX 77030 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jitao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Wayne State University 4 Department of Biomedical Engineering , , Detroit, MI 48201 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salavat R.","family":"Aglyamov","sequence":"additional","affiliation":[{"name":"University of Houston 5 Department of Mechanical Engineering , , Houston, TX 77204 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuliano","family":"Scarcelli","sequence":"additional","affiliation":[{"name":"University of Maryland 6 Fischell Department of Bioengineering , , College Park, MD 20742 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5962-8754","authenticated-orcid":false,"given":"Richard H.","family":"Finnell","sequence":"additional","affiliation":[{"name":"Center for Precision Environmental Health, Baylor College of Medicine 2 , Houston, TX 77030 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5532-5027","authenticated-orcid":false,"given":"Kirill V.","family":"Larin","sequence":"additional","affiliation":[{"name":"University of Houston 1 Department of Biomedical Engineering , , Houston, TX 77204 , USA"},{"name":"Baylor College of Medicine 7 Molecular Physiology and Biophysics , , Houston, TX 77030 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2024,5,17]]},"reference":[{"key":"2024051711273286700_DEV202475C1","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1364\/BOE.387361","article-title":"Multimodal quantitative optical elastography of the crystalline lens with optical coherence elastography and Brillouin microscopy","volume":"11","author":"Ambekar","year":"2020","journal-title":"Biomed. Opt. Express"},{"key":"2024051711273286700_DEV202475C2","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1364\/OL.453996","article-title":"Multimodal imaging system combining optical coherence tomography and Brillouin microscopy for neural tube imaging","volume":"47","author":"Ambekar","year":"2022","journal-title":"Opt. Lett."},{"key":"2024051711273286700_DEV202475C3","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1016\/j.bbadis.2015.02.007","article-title":"Growth arrest in the ribosomopathy, Bowen-Conradi syndrome, is due to dramatically reduced cell proliferation and a defect in mitotic progression","volume":"1852","author":"Armistead","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"2024051711273286700_DEV202475C4","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/nature25742","article-title":"Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo","volume":"554","author":"Barriga","year":"2018","journal-title":"Nature"},{"key":"2024051711273286700_DEV202475C5","doi-asserted-by":"publisher","first-page":"eabi7964","DOI":"10.1126\/scitranslmed.abi7964","article-title":"Mitochondrial-cell cycle cross-talk drives endoreplication in heart disease","volume":"13","author":"Bischof","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"2024051711273286700_DEV202475C6","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s13072-016-0069-1","article-title":"Abnormal X chromosome inactivation and sex-specific gene dysregulation after ablation of FBXL10","volume":"9","author":"Boulard","year":"2016","journal-title":"Epigenet. Chromatin."},{"key":"2024051711273286700_DEV202475C7","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/S0925-4773(01)00579-2","article-title":"Requirement for AP-2alpha in cardiac outflow tract morphogenesis","volume":"110","author":"Brewer","year":"2002","journal-title":"Mech. Dev."},{"key":"2024051711273286700_DEV202475C8","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.ydbio.2003.10.039","article-title":"Wnt1-Cre-mediated deletion of AP-2alpha causes multiple neural crest-related defects","volume":"267","author":"Brewer","year":"2004","journal-title":"Dev. Biol."},{"key":"2024051711273286700_DEV202475C9","doi-asserted-by":"publisher","first-page":"5821","DOI":"10.1074\/jbc.RA118.002180","article-title":"Deletion of the neural tube defect-associated gene Mthfd1l disrupts one-carbon and central energy metabolism in mouse embryos","volume":"293","author":"Bryant","year":"2018","journal-title":"J. Biol. Chem."},{"key":"2024051711273286700_DEV202475C10","doi-asserted-by":"publisher","first-page":"jcs230300","DOI":"10.1242\/jcs.230300","article-title":"Rho kinase-dependent apical constriction counteracts M-phase apical expansion to enable mouse neural tube closure","volume":"132","author":"Butler","year":"2019","journal-title":"J. Cell Sci."},{"key":"2024051711273286700_DEV202475C11","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/bs.ctdb.2022.10.007","article-title":"Gene-environment interactions underlying the etiology of neural tube defects","volume":"152","author":"Caiaffa","year":"2023","journal-title":"Curr. Top. Dev. Biol."},{"key":"2024051711273286700_DEV202475C12","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s13046-022-02343-z","article-title":"Circular RNA circ-MTHFD1L induces HR repair to promote gemcitabine resistance via the miR-615-3p\/RPN6 axis in pancreatic ductal adenocarcinoma","volume":"41","author":"Chen","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"2024051711273286700_DEV202475C13","doi-asserted-by":"publisher","first-page":"5681","DOI":"10.1242\/dev.00808","article-title":"Neural crest development is regulated by the transcription factor Sox9","volume":"130","author":"Cheung","year":"2003","journal-title":"Development"},{"key":"2024051711273286700_DEV202475C14","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.ymeth.2015.08.001","article-title":"Measuring the micromechanical properties of embryonic tissues","volume":"94","author":"Chevalier","year":"2016","journal-title":"Methods"},{"key":"2024051711273286700_DEV202475C15","doi-asserted-by":"publisher","first-page":"15007","DOI":"10.1038\/nrdp.2015.7","article-title":"Spina bifida","volume":"1","author":"Copp","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"2024051711273286700_DEV202475C16","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1016\/j.devcel.2022.07.005","article-title":"Neural crest mechanosensors: seeing old proteins in a new light","volume":"57","author":"Couti\u00f1o","year":"2022","journal-title":"Dev. Cell"},{"key":"2024051711273286700_DEV202475C17","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cmet.2016.08.009","article-title":"One-carbon metabolism in health and disease","volume":"25","author":"Ducker","year":"2017","journal-title":"Cell Metab."},{"key":"2024051711273286700_DEV202475C18","doi-asserted-by":"publisher","first-page":"659612","DOI":"10.3389\/fgene.2021.659612","article-title":"Gene environment interactions in the etiology of neural tube defects","volume":"12","author":"Finnell","year":"2021","journal-title":"Front. Genet."},{"key":"2024051711273286700_DEV202475C19","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1161\/CIRCGENETICS.111.960096","article-title":"Association of genetic variants and incident coronary heart disease in multiethnic cohorts: the PAGE study","volume":"4","author":"Franceschini","year":"2011","journal-title":"Circ. Cardiovasc. Genet."},{"key":"2024051711273286700_DEV202475C20","doi-asserted-by":"publisher","first-page":"5403","DOI":"10.1242\/dev.069849","article-title":"Dual embryonic origin of the mammalian otic vesicle forming the inner ear","volume":"138","author":"Freyer","year":"2011","journal-title":"Development"},{"key":"2024051711273286700_DEV202475C21","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.mcn.2011.01.001","article-title":"Fbxl10\/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly","volume":"46","author":"Fukuda","year":"2011","journal-title":"Mol. Cell. Neurosci."},{"key":"2024051711273286700_DEV202475C22","doi-asserted-by":"publisher","first-page":"E5177","DOI":"10.1073\/pnas.1700934114","article-title":"Biomechanical coupling facilitates spinal neural tube closure in mouse embryos","volume":"114","author":"Galea","year":"2017","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2024051711273286700_DEV202475C23","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1146\/annurev-neuro-062012-170354","article-title":"Neural tube defects","volume":"37","author":"Greene","year":"2014","journal-title":"Annu. Rev. Neurosci."},{"key":"2024051711273286700_DEV202475C24","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/s41598-023-27456-z","article-title":"Time-lapse mechanical imaging of neural tube closure in live embryo using Brillouin microscopy","volume":"13","author":"Handler","year":"2023","journal-title":"Sci. Rep."},{"key":"2024051711273286700_DEV202475C25","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1080\/10408390701537385","article-title":"Raman spectroscopy for monitoring protein structure in muscle food systems","volume":"48","author":"Herrero","year":"2008","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"2024051711273286700_DEV202475C26","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1007\/s11033-015-3870-1","article-title":"Rs6922269 marker at the MTHFD1L gene predict cardiovascular mortality in males after acute coronary syndrome","volume":"42","author":"Hubacek","year":"2015","journal-title":"Mol. Biol. Rep."},{"key":"2024051711273286700_DEV202475C27","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1002\/dvdy.24684","article-title":"Foxc2 is required for proper cardiac neural crest cell migration, outflow tract septation, and ventricle expansion","volume":"247","author":"Inman","year":"2018","journal-title":"Dev. Dyn."},{"key":"2024051711273286700_DEV202475C28","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1056\/NEJMra2116032","article-title":"Spina Bifida","volume":"387","author":"Iskandar","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"2024051711273286700_DEV202475C29","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/s41418-019-0358-x","article-title":"Siva plays a critical role in mouse embryonic development","volume":"27","author":"Jacobs","year":"2020","journal-title":"Cell Death Differ."},{"key":"2024051711273286700_DEV202475C30","doi-asserted-by":"publisher","first-page":"e26029","DOI":"10.1371\/journal.pone.0026029","article-title":"Uniaxial mechanical strain modulates the differentiation of neural crest stem cells into smooth muscle lineage on micropatterned surfaces","volume":"6","author":"Li","year":"2011","journal-title":"PLoS ONE"},{"key":"2024051711273286700_DEV202475C31","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1089\/scd.2019.0161","article-title":"Differentiation of neural crest stem cells in response to matrix stiffness and TGF-\u03b21 in vascular regeneration","volume":"29","author":"Li","year":"2020","journal-title":"Stem Cells Dev."},{"key":"2024051711273286700_DEV202475C32","doi-asserted-by":"publisher","first-page":"e2023163118","DOI":"10.1073\/pnas.2023163118","article-title":"Hindbrain neuropore tissue geometry determines asymmetric cell-mediated closure dynamics in mouse embryos","volume":"118","author":"Maniou","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024051711273286700_DEV202475C33","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.actbio.2019.07.056","article-title":"Micro-indentation and optical coherence tomography for the mechanical characterization of embryos: experimental setup and measurements on chicken embryos","volume":"97","author":"Marrese","year":"2019","journal-title":"Acta Biomater."},{"key":"2024051711273286700_DEV202475C34","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1002\/humu.22459","article-title":"An NTD\u2013associated polymorphism in the 3\u2032 UTR of MTHFD1L can affect disease risk by altering miRNA binding","volume":"35","author":"Minguzzi","year":"2014","journal-title":"Hum. Mutat."},{"key":"2024051711273286700_DEV202475C35","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S1046-2023(02)00292-X","article-title":"Second harmonic generation imaging of endogenous structural proteins","volume":"29","author":"Mohler","year":"2003","journal-title":"Methods"},{"key":"2024051711273286700_DEV202475C36","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1073\/pnas.1211199110","article-title":"Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice","volume":"110","author":"Momb","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2024051711273286700_DEV202475C37","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/978-1-0716-2035-9_29","article-title":"A toolbox to study tissue mechanics in vivo and ex vivo","volume":"2438","author":"Moreira","year":"2022","journal-title":"Methods Mol. Biol."},{"key":"2024051711273286700_DEV202475C38","doi-asserted-by":"publisher","first-page":"e1001130","DOI":"10.1371\/journal.pgen.1001130","article-title":"Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities","volume":"6","author":"Naj","year":"2010","journal-title":"PLoS Genet."},{"key":"2024051711273286700_DEV202475C39","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1242\/dev.145904","article-title":"Neural tube closure: cellular, molecular and biomechanical mechanisms","volume":"144","author":"Nikolopoulou","year":"2017","journal-title":"Development"},{"key":"2024051711273286700_DEV202475C40","doi-asserted-by":"publisher","first-page":"e89029","DOI":"10.1371\/journal.pone.0089029","article-title":"Genetic polymorphism rs6922269 in the MTHFD1L gene is associated with survival and baseline active vitamin B12 levels in post-acute coronary syndromes patients","volume":"9","author":"Palmer","year":"2014","journal-title":"PLoS ONE"},{"key":"2024051711273286700_DEV202475C41","doi-asserted-by":"publisher","first-page":"7833","DOI":"10.1021\/acs.chemrev.9b00019","article-title":"Brillouin light scattering: applications in biomedical sciences","volume":"119","author":"Palombo","year":"2019","journal-title":"Chem. Rev."},{"key":"2024051711273286700_DEV202475C42","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1007\/s10439-011-0466-3","article-title":"Acoustic radiation force impulse (ARFI) imaging of zebrafish embryo by high-frequency coded excitation sequence","volume":"40","author":"Park","year":"2012","journal-title":"Ann. Biomed. Eng."},{"key":"2024051711273286700_DEV202475C43","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1002\/humu.21109","article-title":"A common variant in MTHFD1L is associated with neural tube defects and mRNA splicing efficiency","volume":"30","author":"Parle-McDermott","year":"2009","journal-title":"Hum. Mutat."},{"key":"2024051711273286700_DEV202475C44","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.ydbio.2014.06.021","article-title":"Geminin loss causes neural tube defects through disrupted progenitor specification and neuronal differentiation","volume":"393","author":"Patterson","year":"2014","journal-title":"Dev. Biol."},{"key":"2024051711273286700_DEV202475C45","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.neuroscience.2017.09.049","article-title":"Genes linking mitochondrial function, cognitive impairment and depression are associated with endophenotypes serving precision medicine","volume":"370","author":"Petschner","year":"2018","journal-title":"Neuroscience"},{"key":"2024051711273286700_DEV202475C46","doi-asserted-by":"publisher","first-page":"4612","DOI":"10.1074\/jbc.M109.079855","article-title":"Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos","volume":"285","author":"Pike","year":"2010","journal-title":"J. Biol. Chem."},{"key":"2024051711273286700_DEV202475C47","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1038\/s41592-019-0543-3","article-title":"Brillouin microscopy: an emerging tool for mechanobiology","volume":"16","author":"Prevedel","year":"2019","journal-title":"Nat. Methods"},{"key":"2024051711273286700_DEV202475C48","doi-asserted-by":"publisher","first-page":"50902","DOI":"10.1117\/1.JBO.21.5.050902","article-title":"Optical coherence tomography for embryonic imaging: a review","volume":"21","author":"Raghunathan","year":"2016","journal-title":"J. Biomed. Opt."},{"key":"2024051711273286700_DEV202475C49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1117\/1.JBO.22.8.086013","article-title":"Evaluating biomechanical properties of murine embryos using Brillouin microscopy and optical coherence tomography","volume":"22","author":"Raghunathan","year":"2017","journal-title":"J. Biomed. Opt."},{"key":"2024051711273286700_DEV202475C50","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1098\/rspb.1982.0021","article-title":"The measurement and interpretation of Brillouin scattering in the lens of the eye","volume":"214","author":"Randall","year":"1982","journal-title":"Proc. R. Soc. Lond. Ser. B Biol. Sci."},{"key":"2024051711273286700_DEV202475C51","doi-asserted-by":"publisher","first-page":"e13273","DOI":"10.7554\/eLife.13273","article-title":"Regulation of cell protrusions by small GTPases during fusion of the neural folds","volume":"5","author":"Rolo","year":"2016","journal-title":"eLife"},{"key":"2024051711273286700_DEV202475C52","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/nphoton.2007.250","article-title":"Confocal Brillouin microscopy for three-dimensional mechanical imaging","volume":"2","author":"Scarcelli","year":"2007","journal-title":"Nat. Photonics"},{"key":"2024051711273286700_DEV202475C53","doi-asserted-by":"publisher","first-page":"1000237","DOI":"10.3389\/fcell.2022.1000237","article-title":"Mouse embryo phenotyping with optical coherence tomography","volume":"10","author":"Scully","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"2024051711273286700_DEV202475C54","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1242\/dev.118.3.691","article-title":"Segmental migration of the hindbrain neural crest does not arise from its segmental generation","volume":"118","author":"Sechrist","year":"1993","journal-title":"Development"},{"key":"2024051711273286700_DEV202475C55","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1242\/dev.116.2.297","article-title":"Vital dye analysis of cranial neural crest cell migration in the mouse embryo","volume":"116","author":"Serbedzija","year":"1992","journal-title":"Development"},{"key":"2024051711273286700_DEV202475C56","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.ydbio.2014.12.005","article-title":"Tissue mechanics and adhesion during embryo development","volume":"401","author":"Shawky","year":"2015","journal-title":"Dev. Biol."},{"key":"2024051711273286700_DEV202475C57","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1038\/s41586-021-04210-x","article-title":"Collective durotaxis along a self-generated stiffness gradient in vivo","volume":"600","author":"Shellard","year":"2021","journal-title":"Nature"},{"key":"2024051711273286700_DEV202475C58","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1002\/bdr2.1591","article-title":"Deletion of neural tube defect-associated gene Mthfd1l causes reduced cranial mesenchyme density","volume":"111","author":"Shin","year":"2019","journal-title":"Birth Defects Res."},{"key":"2024051711273286700_DEV202475C59","doi-asserted-by":"publisher","first-page":"BSR20211783","DOI":"10.1042\/BSR20211783","article-title":"Integrative analysis reveals methylenetetrahydrofolate dehydrogenase 1-like as an independent shared diagnostic and prognostic biomarker in five different human cancers","volume":"42","author":"Sial","year":"2022","journal-title":"Biosci. Rep."},{"key":"2024051711273286700_DEV202475C60","doi-asserted-by":"publisher","first-page":"e47929","DOI":"10.7554\/eLife.47929","article-title":"Cardiac neural crest contributes to cardiomyocytes in amniotes and heart regeneration in zebrafish","volume":"8","author":"Tang","year":"2019","journal-title":"eLife"},{"key":"2024051711273286700_DEV202475C61","doi-asserted-by":"publisher","first-page":"e39356","DOI":"10.7554\/eLife.39356","article-title":"Rapid changes in tissue mechanics regulate cell behaviour in the developing embryonic brain","volume":"8","author":"Thompson","year":"2019","journal-title":"eLife"},{"key":"2024051711273286700_DEV202475C62","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1146\/annurev.nutr.012809.104810","article-title":"Compartmentalization of Mammalian folate-mediated one-carbon metabolism","volume":"30","author":"Tibbetts","year":"2010","journal-title":"Annu. Rev. Nutr."},{"key":"2024051711273286700_DEV202475C63","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1126\/science.1064540","article-title":"Role of the isthmus and FGFs in resolving the paradox of neural crest plasticity and prepatterning","volume":"295","author":"Trainor","year":"2002","journal-title":"Science"},{"key":"2024051711273286700_DEV202475C64","doi-asserted-by":"publisher","first-page":"7519","DOI":"10.1021\/acs.analchem.5b02104","article-title":"Dual Raman-Brillouin microscope for chemical and mechanical characterization and imaging","volume":"87","author":"Traverso","year":"2015","journal-title":"Anal. Chem."},{"key":"2024051711273286700_DEV202475C65","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.1007\/s00216-021-03308-5","article-title":"Metabotype analysis of Mthfd1l-null mouse embryos using desorption electrospray ionization mass spectrometry imaging","volume":"413","author":"Vaughn","year":"2021","journal-title":"Anal. Bioanal. Chem."},{"key":"2024051711273286700_DEV202475C66","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1080\/10799893.2020.1769658","article-title":"MTHFD1L as a folate cycle enzyme correlates with prognostic outcome and its knockdown impairs cell invasive behaviors in osteosarcoma via mediating the AKT\/mTOR pathway","volume":"40","author":"Wang","year":"2020","journal-title":"J. Recept. Signal Transduct. Res."},{"key":"2024051711273286700_DEV202475C67","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1364\/BOE.381359","article-title":"Label-free optical imaging in developmental biology [Invited]","volume":"11","author":"Wang","year":"2020","journal-title":"Biomed. Opt. Express"},{"key":"2024051711273286700_DEV202475C68","doi-asserted-by":"publisher","first-page":"065006","DOI":"10.1088\/1478-3975\/aa6d18","article-title":"The role of cell body density in ruminant retina mechanics assessed by atomic force and Brillouin microscopy","volume":"14","author":"Weber","year":"2017","journal-title":"Phys. Biol."},{"key":"2024051711273286700_DEV202475C69","doi-asserted-by":"publisher","first-page":"2763","DOI":"10.3390\/ijms18122763","article-title":"A genome-wide association study and complex network identify four core hub genes in bipolar disorder","volume":"18","author":"Xie","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"2024051711273286700_DEV202475C70","doi-asserted-by":"publisher","first-page":"101869","DOI":"10.1016\/j.tice.2022.101869","article-title":"MTHFD1L knockdown diminished cells growth in papillary thyroid cancer","volume":"77","author":"Yi","year":"2022","journal-title":"Tissue Cell"},{"key":"2024051711273286700_DEV202475C71","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1002\/bdr2.1389","article-title":"Tissue biomechanics during cranial neural tube closure measured by Brillouin microscopy and optical coherence tomography","volume":"111","author":"Zhang","year":"2019","journal-title":"Birth Defects Res."},{"key":"2024051711273286700_DEV202475C72","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.21037\/tcr-20-2798","article-title":"NAD-dependent methylenetetrahydrofolate dehydrogenase inhibits oral squamous cell carcinoma cell proliferation and promotes apoptosis","volume":"10","author":"Zhao","year":"2021","journal-title":"Transl. Cancer Res."},{"key":"2024051711273286700_DEV202475C73","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1242\/dev.026211","article-title":"Actomyosin stiffens the vertebrate embryo during crucial stages of elongation and neural tube closure","volume":"136","author":"Zhou","year":"2009","journal-title":"Development"},{"key":"2024051711273286700_DEV202475C74","doi-asserted-by":"publisher","first-page":"113584","DOI":"10.1016\/j.yexcr.2023.113584","article-title":"MTHFD1L confers a poor prognosis and malignant phenotype in esophageal squamous cell carcinoma by activating the ERK5 signaling pathway","volume":"427","author":"Zhou","year":"2023","journal-title":"Exp. Cell Res."},{"key":"2024051711273286700_DEV202475C75","doi-asserted-by":"publisher","first-page":"7569","DOI":"10.1002\/jcp.27518","article-title":"Matrix stiffness modulates the differentiation of neural crest stem cells in vivo","volume":"234","author":"Zhu","year":"2019","journal-title":"J. Cell. Physiol."}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.202475\/3421603\/dev202475.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.202475\/3427959\/dev202475.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.202475\/3427959\/dev202475.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T11:27:44Z","timestamp":1715945264000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/151\/10\/dev202475\/347546\/Optical-coherence-tomography-guided-Brillouin"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,15]]},"references-count":75,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,5,15]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.202475","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,15]]},"article-number":"dev202475"}}