{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:29:29Z","timestamp":1790980169798,"version":"4.1.0"},"reference-count":56,"publisher":"The Company of Biologists","issue":"11","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 GM116926"],"award-info":[{"award-number":["R01 GM116926"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"crossref","award":["R35 GM136340"],"award-info":[{"award-number":["R35 GM136340"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institute of Child Health and Human Development","award":["P50 HD055764"],"award-info":[{"award-number":["P50 HD055764"]}]},{"DOI":"10.13039\/501100019125","name":"Sorbonne Universit\u00e9","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100019125","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["202112871"],"award-info":[{"award-number":["202112871"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004721","name":"University of Tokyo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004721","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100005595","name":"University of California","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100005595","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The RNA-binding protein cytoplasmic polyadenylation element binding 1 (CPEB1) plays a fundamental role in regulating mRNA translation in oocytes. However, the specifics of how and which protein kinase cascades modulate CPEB1 activity are still controversial. Using genetic and pharmacological tools, and detailed time courses, we have re-evaluated the relationship between CPEB1 phosphorylation and translation activation during mouse oocyte maturation. We show that both the CDK1\/MAPK and AURKA\/PLK1 pathways converge on CPEB1 phosphorylation during prometaphase of meiosis I. Only inactivation of the CDK1\/MAPK pathway disrupts translation, whereas inactivation of either pathway alone leads to CPEB1 stabilization. However, CPEB1 stabilization induced by inactivation of the AURKA\/PLK1 pathway does not affect translation, indicating that destabilization and\/or degradation is not linked to translational activation. The accumulation of endogenous CCNB1 protein closely recapitulates the translation data that use an exogenous template. These findings support the overarching hypothesis that the activation of translation during prometaphase in mouse oocytes relies on a CDK1\/MAPK-dependent CPEB1 phosphorylation, and that translational activation precedes CPEB1 destabilization.<\/jats:p>","DOI":"10.1242\/dev.202712","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T05:34:32Z","timestamp":1716528872000},"source":"Crossref","is-referenced-by-count":15,"title":["Multiple intersecting pathways are involved in CPEB1 phosphorylation and regulation of translation during mouse oocyte meiosis"],"prefix":"10.1242","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5435-3712","authenticated-orcid":false,"given":"Chisato","family":"Kunitomi","sequence":"first","affiliation":[{"name":"Center for Reproductive Sciences, University of California 1 , San Francisco, CA 94143 , USA"},{"name":"Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California 2 , San Francisco, CA 94143 , USA"},{"name":"University of California 3 Department of Obstetrics and Gynecology and Reproductive Sciences , , San Francisco, CA 94143 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayra","family":"Romero","sequence":"additional","affiliation":[{"name":"Rutgers, The State University of New Jersey 4 , Piscataway, NJ 08854, USA"},{"name":"Human Genetics Institute of New Jersey 5 , Piscataway, NJ 08854, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0456-8950","authenticated-orcid":false,"given":"Enrico Maria","family":"Daldello","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, CNRS 6 , Laboratoire de Biologie du D\u00e9veloppement - , F-75005 Paris , France"},{"name":"Institut de Biologie Paris Seine, LBD - IBPS 6 , Laboratoire de Biologie du D\u00e9veloppement - , F-75005 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6113-1184","authenticated-orcid":false,"given":"Karen","family":"Schindler","sequence":"additional","affiliation":[{"name":"Rutgers, The State University of New Jersey 4 , Piscataway, NJ 08854, USA"},{"name":"Human Genetics Institute of New Jersey 5 , Piscataway, NJ 08854, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4755-9146","authenticated-orcid":false,"given":"Marco","family":"Conti","sequence":"additional","affiliation":[{"name":"Center for Reproductive Sciences, University of California 1 , San Francisco, CA 94143 , USA"},{"name":"Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California 2 , San Francisco, CA 94143 , USA"},{"name":"University of California 3 Department of Obstetrics and Gynecology and Reproductive Sciences , , San Francisco, CA 94143 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2024,6,4]]},"reference":[{"key":"2024060412261177500_DEV202712C1","doi-asserted-by":"publisher","first-page":"dev199560","DOI":"10.1242\/dev.199560","article-title":"Aurora kinase B inhibits aurora kinase A to control maternal mRNA translation in mouse oocytes","volume":"148","author":"Aboelenain","year":"2021","journal-title":"Development"},{"key":"2024060412261177500_DEV202712C2","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1242\/jcs.114.2.257","article-title":"The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes","volume":"114","author":"Abrieu","year":"2001","journal-title":"J. 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