{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:25:27Z","timestamp":1791498327508,"version":"4.3.4"},"reference-count":67,"publisher":"The Company of Biologists","issue":"19","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"crossref","award":["1ZIADC000085-01"],"award-info":[{"award-number":["1ZIADC000085-01"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"crossref","award":["R01 DC018304"],"award-info":[{"award-number":["R01 DC018304"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"crossref","award":["R01 DC015242"],"award-info":[{"award-number":["R01 DC015242"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Hair cells of the inner ear and lateral-line system rely on specialized ribbon synapses to transmit sensory information to the central nervous system. The molecules required to assemble these synapses are not fully understood. We show that Nrxn3, a presynaptic adhesion molecule, is crucial for ribbon-synapse maturation in hair cells. In both mouse and zebrafish models, the loss of Nrxn3 results in significantly fewer intact ribbon synapses. We show in zebrafish that, initially, Nrxn3 loss does not alter pre- and postsynapse numbers but, later, synapses fail to pair, leading to postsynapse loss. We also demonstrate that Nrxn3 subtly influences synapse selectivity in zebrafish lateral-line hair cells that detect anterior flow. Loss of Nrxn3 leads to a 60% loss of synapses in zebrafish, which dramatically reduces pre- and postsynaptic responses. Despite fewer synapses, auditory responses in zebrafish and mice are unaffected. This work demonstrates that Nrxn3 is a crucial and conserved molecule required for the maturation of ribbon synapses. Understanding how ribbon synapses mature is essential to generating new therapies to treat synaptopathies linked to auditory or vestibular dysfunction.<\/jats:p>","DOI":"10.1242\/dev.202723","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T11:10:57Z","timestamp":1725966657000},"source":"Crossref","is-referenced-by-count":14,"title":["Presynaptic Nrxn3 is essential for ribbon-synapse maturation in hair cells"],"prefix":"10.1242","volume":"151","author":[{"given":"Alma","family":"Jukic","sequence":"first","affiliation":[{"name":"National Institute on Deafness and Other Communication Disorders 1 Section on Sensory Cell Development and Function , , Bethesda, MD 20892 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengchang","family":"Lei","sequence":"additional","affiliation":[{"name":"National Institute on Deafness and Other Communication Disorders 1 Section on Sensory Cell Development and Function , , Bethesda, MD 20892 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5218-265X","authenticated-orcid":false,"given":"Elizabeth R.","family":"Cebul","sequence":"additional","affiliation":[{"name":"National Institute on Deafness and Other Communication Disorders 1 Section on Sensory Cell Development and Function , , Bethesda, MD 20892 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Pinter","sequence":"additional","affiliation":[{"name":"National Institute on Deafness and Other Communication Disorders 1 Section on Sensory Cell Development and Function , , Bethesda, MD 20892 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yommi","family":"Tadesse","sequence":"additional","affiliation":[{"name":"National Institute on Deafness and Other Communication Disorders 1 Section on Sensory Cell Development and Function , , Bethesda, MD 20892 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9519-3559","authenticated-orcid":false,"given":"Amandine","family":"Jarysta","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory 2 , Bar Harbor, ME 04609 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"David","sequence":"additional","affiliation":[{"name":"National Institute on Deafness and Other Communication Disorders 1 Section on Sensory Cell Development and Function , , Bethesda, MD 20892 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3860-6759","authenticated-orcid":false,"given":"Natalie","family":"Mosqueda","sequence":"additional","affiliation":[{"name":"National Institute on Deafness and Other Communication Disorders 1 Section on Sensory Cell Development and Function , , Bethesda, MD 20892 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2708-6273","authenticated-orcid":false,"given":"Basile","family":"Tarchini","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory 2 , Bar Harbor, ME 04609 ,","place":["USA"]},{"name":"Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine 3 , Boston, MA 02111 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1065-8215","authenticated-orcid":false,"given":"Katie","family":"Kindt","sequence":"additional","affiliation":[{"name":"National Institute on Deafness and Other Communication Disorders 1 Section on Sensory Cell Development and Function , , Bethesda, MD 20892 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"2024101008450800700_DEV202723C61","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1038\/nn.4037","article-title":"Distinct circuit-dependent functions of presynaptic neurexin-3 at GABAergic and glutamatergic synapses","volume":"18","author":"Aoto","year":"2015","journal-title":"Nat. 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