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Whereas first-order (FO) nuclei \u2013 also called core nuclei \u2013 relay input from sensory organs on the body surface and project to primary cortical sensory areas, higher-order (HO) nuclei \u2013 matrix nuclei \u2013 instead receive their driver input from the cortex and project to secondary and associative areas within cortico-thalamo-cortical loops. Input-dependent processes have been shown to play a crucial role in the emergence of FO thalamic neuron identity from a ground-state HO neuron identity, yet how this identity emerges during development remains unknown. Here, using single-cell RNA sequencing of the developing mouse embryonic thalamus, we show that, although they are born together, HO neurons start differentiating earlier than FO neurons. Within the FO visual thalamus, postnatal peripheral input is crucial for the maturation of excitatory, but not inhibitory, neurons. Our findings reveal different differentiation tempos and input sensitivities of HO and FO neurons, and highlight neuron type-specific molecular differentiation programs in the developing thalamus.<\/jats:p>","DOI":"10.1242\/dev.202764","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T12:47:37Z","timestamp":1727700457000},"source":"Crossref","is-referenced-by-count":13,"title":["Developmental emergence of first- and higher-order thalamic neuron molecular identities"],"prefix":"10.1242","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4225-0628","authenticated-orcid":false,"given":"Quentin","family":"Lo Giudice","sequence":"first","affiliation":[{"name":"University of Geneva 1 Department of Basic Neurosciences , , 1202 Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8762-833X","authenticated-orcid":false,"given":"Robin J.","family":"Wagener","sequence":"additional","affiliation":[{"name":"University of Geneva 1 Department of Basic Neurosciences , , 1202 Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8067-1802","authenticated-orcid":false,"given":"Philipp","family":"Abe","sequence":"additional","affiliation":[{"name":"University of Geneva 1 Department of Basic Neurosciences , , 1202 Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2997-0989","authenticated-orcid":false,"given":"Laura","family":"Frangeul","sequence":"additional","affiliation":[{"name":"University of Geneva 1 Department of Basic Neurosciences , , 1202 Geneva ,","place":["Switzerland"]},{"name":"NeuroNA Human Cellular Neuroscience Platform (HCNP), Fondation Campus Biotech Geneva 2 , 1202 Geneva ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2438-4769","authenticated-orcid":false,"given":"Denis","family":"Jabaudon","sequence":"additional","affiliation":[{"name":"University of Geneva 1 Department of Basic Neurosciences , , 1202 Geneva ,","place":["Switzerland"]},{"name":"Geneva University Hospital 3 Clinic of Neurology , , 1211 Geneva ,","place":["Switzerland"]},{"name":"Universit\u00e9 Paris Cit\u00e9, Imagine Institute 4 , 75015 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"2024093016462489400_DEV202764C1","author":"Allen Institute for Brain Science"},{"key":"2024093016462489400_DEV202764C2","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1002\/cne.901880309","article-title":"Development of the diencephalon in the rat. 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