{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:34:46Z","timestamp":1773797686726,"version":"3.50.1"},"reference-count":59,"publisher":"The Company of Biologists","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Many genes that regulate development share a 180\u2005bp DNA sequence, called the homeobox, encoding a 60 amino acid DNA-binding domain ( McGinnis et al., 1984c; Scott and Weiner, 1984). Because the homeobox is long enough to hybridize to related, but different, genes, it has been a powerful tool for discovering developmental regulators. This year is the 40th anniversary of the first homeobox report. Here, I describe work carried out at Indiana University that led to the discovery of the homeobox. The accompanying Perspective from McGinnis and Levine describes the independent discovery made at the Biozentrum in Basel ( McGinnis and Levine, 2024). At the time, the competition was lively but, as we all met each other \u2013 and realized that no one cares more about your work than competitors \u2013 we fortunately became friends and have enjoyed many years of following and respecting each other's work.<\/jats:p>","DOI":"10.1242\/dev.202776","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T00:01:36Z","timestamp":1710720096000},"source":"Crossref","is-referenced-by-count":6,"title":["40\u2005years of the homeobox: either it is wrong or it is quite interesting"],"prefix":"10.1242","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6313-256X","authenticated-orcid":false,"given":"Matthew P.","family":"Scott","sequence":"first","affiliation":[{"name":"Department of Developmental Biology, Beckman Center B300, 279 Campus Drive, Stanford, CA 94305, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2024,3,18]]},"reference":[{"key":"2024031800013224200_DEV202776C1","volume-title":"Materials for the Study of Variation","author":"Bateson","year":"1894"},{"key":"2024031800013224200_DEV202776C2","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1126\/science.221.4605.23","article-title":"Molecular genetics of the bithorax complex in Drosophila melanogaster","volume":"221","author":"Bender","year":"1983","journal-title":"Science"},{"key":"2024031800013224200_DEV202776C3","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1002\/j.1460-2075.1988.tb03004.x","article-title":"The role of localization of bicoid RNA in organizing the anterior pattern of the Drosophila embryo","volume":"7","author":"Berleth","year":"1988","journal-title":"EMBO J."},{"key":"2024031800013224200_DEV202776C58","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1093\/oxfordjournals.humrep.a136802","article-title":"Organization of human homeobox genes","volume":"3","author":"Boncinelli","year":"1988","journal-title":"Hum. 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