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Spermatozoa are male gametes, specialized cells that can be divided into two parts: the head and the flagellum. The head contains a vesicle called the acrosome that undergoes exocytosis and the flagellum is a motility apparatus that propels the spermatozoa forward and can be divided into two components, axonemes and accessory structures. For spermatozoa to fertilize oocytes, the acrosome and flagellum must be formed correctly. In this Review, we describe comprehensively how functional spermatozoa develop in mammals during spermiogenesis, including the formation of acrosomes, axonemes and accessory structures by focusing on analyses of mouse models.<\/jats:p>","DOI":"10.1242\/dev.202838","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T06:26:34Z","timestamp":1721629594000},"source":"Crossref","is-referenced-by-count":50,"title":["Development of functional spermatozoa in mammalian spermiogenesis"],"prefix":"10.1242","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4758-5803","authenticated-orcid":false,"given":"Haruhiko","family":"Miyata","sequence":"first","affiliation":[{"name":"Research Institute for Microbial Diseases, Osaka University 1 , Suita, Osaka 565-0871 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3739-7163","authenticated-orcid":false,"given":"Keisuke","family":"Shimada","sequence":"additional","affiliation":[{"name":"Research Institute for Microbial Diseases, Osaka University 1 , Suita, Osaka 565-0871 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6300-4234","authenticated-orcid":false,"given":"Yuki","family":"Kaneda","sequence":"additional","affiliation":[{"name":"Research Institute for Microbial Diseases, Osaka University 1 , Suita, Osaka 565-0871 , Japan"},{"name":"Osaka University 2 Graduate School of Pharmaceutical Sciences , , Suita, Osaka 565-0871 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9859-6217","authenticated-orcid":false,"given":"Masahito","family":"Ikawa","sequence":"additional","affiliation":[{"name":"Research Institute for Microbial Diseases, Osaka University 1 , Suita, Osaka 565-0871 , Japan"},{"name":"Osaka University 2 Graduate School of Pharmaceutical Sciences , , Suita, Osaka 565-0871 , Japan"},{"name":"The Institute of Medical Science, The University of Tokyo 3 , Minato-ku, Tokyo 108-8639 , Japan"},{"name":"Center for Infectious Disease Education and Research, Osaka University 4 , Suita, Osaka 565-0871 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"key":"2024072210252639800_DEV202838C1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/rmb2.12067","article-title":"Revolutionizing male fertility factor research in mice by using the genome editing tool CRISPR\/Cas9","volume":"17","author":"Abbasi","year":"2018","journal-title":"Reprod. 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