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However, how GATA6 regulates cardiac morphology during embryogenesis is undefined. We used knockout and conditional mutant zebrafish alleles to investigate the spatiotemporal role of gata6 during cardiogenesis. Loss of gata6 specifically impacts atrioventricular valve formation and recruitment of epicardium, with a prominent loss of arterial pole cardiac cells, including those of the ventricle and outflow tract. However, there are no obvious defects in cardiac progenitor cell specification, proliferation or death. Conditional loss of gata6 starting at 24\u2005h is sufficient to disrupt the addition of late differentiating cardiomyocytes at the arterial pole, with decreased expression levels of anterior secondary heart field (SHF) markers spry4 and mef2cb. Conditional loss of gata6 in the endoderm is sufficient to phenocopy the straight knockout, resulting in a significant loss of ventricular and outflow tract tissue. Exposure to a Dusp6 inhibitor largely rescues the loss of ventricular cells in gata6\u2212\/\u2212 larvae. Thus, gata6 functions in endoderm are mediated by FGF signaling to regulate the addition of anterior SHF progenitor derivatives during heart formation.<\/jats:p>","DOI":"10.1242\/dev.202895","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T14:09:37Z","timestamp":1723471777000},"source":"Crossref","is-referenced-by-count":4,"title":["Gata6 functions in zebrafish endoderm to regulate late differentiating arterial pole cardiogenesis"],"prefix":"10.1242","volume":"151","author":[{"given":"Jessica","family":"Sam","sequence":"first","affiliation":[{"name":"Weill Cornell Medicine 1 Department of Surgery , , New York, NY 10065 , USA"},{"name":"Weill Cornell Graduate School of Medical Sciences 2 , New York, NY 10065 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Torregroza","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine 1 Department of Surgery , , New York, NY 10065 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7148-9849","authenticated-orcid":false,"given":"Todd","family":"Evans","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine 1 Department of Surgery , , New York, NY 10065 , USA"},{"name":"Hartman Institute for Therapeutic Organ Regeneration, Weill Cornell Medicine 3 , New York, NY 10065 , USA"},{"name":"Center for Genomic Health, Weill Cornell Medicine 4 , New York, NY 10065 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2024,9,2]]},"reference":[{"key":"2024090214370484000_DEV202895C1","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1038\/nature03994","article-title":"In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog","volume":"437","author":"Ahn","year":"2005","journal-title":"Nature"},{"key":"2024090214370484000_DEV202895C2","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1242\/dev.129.8.1935","article-title":"Regulation of avian cardiogenesis by Fgf8 signaling","volume":"129","author":"Alsan","year":"2002","journal-title":"Development"},{"key":"2024090214370484000_DEV202895C3","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1242\/dev.02264","article-title":"Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations","volume":"133","author":"Arnold","year":"2006","journal-title":"Development"},{"key":"2024090214370484000_DEV202895C4","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.ydbio.2023.04.001","article-title":"Aberrant differentiation of second heart field mesoderm prefigures cellular defects in the outflow tract in response to loss of FGF8","volume":"499","author":"Astrof","year":"2023","journal-title":"Dev. 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